Tags

Type your tag names separated by a space and hit enter

Dietary Factors Reduce Risk of Acute Pancreatitis in a Large Multiethnic Cohort.

Abstract

BACKGROUND & AIMS

Pancreatitis is a source of substantial morbidity and health cost in the United States. Little is known about how diet might contribute to its pathogenesis. To characterize dietary factors that are associated with risk of pancreatitis by disease subtype, we conducted a prospective analysis of 145,886 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites in the Multiethnic Cohort.

METHODS

In the Multiethnic Cohort (age at baseline, 45-75 y), we identified cases of pancreatitis using hospitalization claim files from 1993 through 2012. Patients were categorized as having gallstone-related acute pancreatitis (AP) (n = 1210), AP not related to gallstones (n = 1222), or recurrent AP or suspected chronic pancreatitis (n = 378). Diet information was obtained from a questionnaire administered when the study began. Associations were estimated by hazard ratios and 95% confidence intervals using Cox proportional hazard models adjusted for confounders.

RESULTS

Dietary intakes of saturated fat (P trend = .0011) and cholesterol (P trend = .0008) and their food sources, including red meat (P trend < .0001) and eggs (P trend = .0052), were associated positively with gallstone-related AP. Fiber intake, however, was associated inversely with gallstone-related AP (P trend = .0005) and AP not related to gallstones (P trend = .0035). Vitamin D, mainly from milk, was associated inversely with gallstone-related AP (P trend = .0015), whereas coffee consumption protected against AP not related to gallstones (P trend < .0001). With the exception of red meat, no other dietary factors were associated with recurrent acute or suspected chronic pancreatitis.

CONCLUSIONS

Associations between dietary factors and pancreatitis were observed mainly for gallstone-related AP. Interestingly, dietary fiber protected against AP related and unrelated to gallstones. Coffee drinking protected against AP not associated with gallstones. Further studies are warranted to confirm our findings.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address: vsetiawa@usc.edu.

    ,

    Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, and Department of Veterans Affairs, Los Angeles, California.

    ,

    Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

    ,

    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

    ,

    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.

    ,

    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.

    ,

    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Memorial Sloan Kettering Cancer Center, New York, New York.

    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

    Source

    MeSH

    Aged
    Diet
    Feeding Behavior
    Female
    Humans
    Male
    Middle Aged
    Pancreatitis, Acute Necrotizing
    Prospective Studies
    Risk Assessment
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    27609706

    Citation

    Setiawan, Veronica Wendy, et al. "Dietary Factors Reduce Risk of Acute Pancreatitis in a Large Multiethnic Cohort." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 15, no. 2, 2017, pp. 257-265.e3.
    Setiawan VW, Pandol SJ, Porcel J, et al. Dietary Factors Reduce Risk of Acute Pancreatitis in a Large Multiethnic Cohort. Clin Gastroenterol Hepatol. 2017;15(2):257-265.e3.
    Setiawan, V. W., Pandol, S. J., Porcel, J., Wei, P. C., Wilkens, L. R., Le Marchand, L., ... Monroe, K. R. (2017). Dietary Factors Reduce Risk of Acute Pancreatitis in a Large Multiethnic Cohort. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 15(2), pp. 257-265.e3. doi:10.1016/j.cgh.2016.08.038.
    Setiawan VW, et al. Dietary Factors Reduce Risk of Acute Pancreatitis in a Large Multiethnic Cohort. Clin Gastroenterol Hepatol. 2017;15(2):257-265.e3. PubMed PMID: 27609706.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary Factors Reduce Risk of Acute Pancreatitis in a Large Multiethnic Cohort. AU - Setiawan,Veronica Wendy, AU - Pandol,Stephen J, AU - Porcel,Jacqueline, AU - Wei,Pengxiao C, AU - Wilkens,Lynne R, AU - Le Marchand,Loïc, AU - Pike,Malcolm C, AU - Monroe,Kristine R, Y1 - 2016/09/05/ PY - 2016/07/21/received PY - 2016/08/24/revised PY - 2016/08/25/accepted PY - 2016/10/30/pubmed PY - 2017/9/7/medline PY - 2016/9/10/entrez KW - Epidemiology KW - Pancreas KW - Population SP - 257 EP - 265.e3 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 15 IS - 2 N2 - BACKGROUND & AIMS: Pancreatitis is a source of substantial morbidity and health cost in the United States. Little is known about how diet might contribute to its pathogenesis. To characterize dietary factors that are associated with risk of pancreatitis by disease subtype, we conducted a prospective analysis of 145,886 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites in the Multiethnic Cohort. METHODS: In the Multiethnic Cohort (age at baseline, 45-75 y), we identified cases of pancreatitis using hospitalization claim files from 1993 through 2012. Patients were categorized as having gallstone-related acute pancreatitis (AP) (n = 1210), AP not related to gallstones (n = 1222), or recurrent AP or suspected chronic pancreatitis (n = 378). Diet information was obtained from a questionnaire administered when the study began. Associations were estimated by hazard ratios and 95% confidence intervals using Cox proportional hazard models adjusted for confounders. RESULTS: Dietary intakes of saturated fat (P trend = .0011) and cholesterol (P trend = .0008) and their food sources, including red meat (P trend < .0001) and eggs (P trend = .0052), were associated positively with gallstone-related AP. Fiber intake, however, was associated inversely with gallstone-related AP (P trend = .0005) and AP not related to gallstones (P trend = .0035). Vitamin D, mainly from milk, was associated inversely with gallstone-related AP (P trend = .0015), whereas coffee consumption protected against AP not related to gallstones (P trend < .0001). With the exception of red meat, no other dietary factors were associated with recurrent acute or suspected chronic pancreatitis. CONCLUSIONS: Associations between dietary factors and pancreatitis were observed mainly for gallstone-related AP. Interestingly, dietary fiber protected against AP related and unrelated to gallstones. Coffee drinking protected against AP not associated with gallstones. Further studies are warranted to confirm our findings. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/27609706/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(16)30619-X DB - PRIME DP - Unbound Medicine ER -