Tags

Type your tag names separated by a space and hit enter

Hepatitis E: Discovery, global impact, control and cure.
World J Gastroenterol. 2016 Aug 21; 22(31):7030-45.WJ

Abstract

Hepatitis E was identified as an epidemic of non-A, non-B hepatitis from Kashmir, India in 1978. Hepatitis E virus (HEV), the etiological agent is the sole member of family Hepeviridae. The virus has marked heterogeneity and infects many animals like bats, camel, chicken, deer, boar, mongoose, pigs, rats, rabbit and cutthroat trout. Hepatitis E is a disease with a major global impact and has two distinct epidemiological patterns. Hepatitis E is an imperative health issue in developing nations, transmitted through sullied water and happens most every now in young adults. The disease is particularly severe during pregnancy and in people with underlying liver cirrhosis. Autochthonous hepatitis E is increasingly recognized in developed countries. The virus infects domestic pigs, wild boar and Sika deer in these countries. HEV infections in humans occur by eating the undercooked game flesh, raw liver from supermarkets and Figatelli sausages. Blood transfusion-associated HEV infections occur in many countries and screening of donors for HEV RNA is under consideration. Hepatitis E causes a number of extrahepatic diseases, including a wide spectrum of neurological syndromes. HEV genotype 3 causes prolonged viremia, chronic hepatitis, liver fibrosis and cirrhosis in organ transplant patients. The virus is amenable to ribavirin monotherapy and most patients clear the virus in a few weeks. Hepatitis E vaccine -239, marketed in China, has shown high efficacy with sustained protection for over four years.

Authors+Show Affiliations

Mohammad S Khuroo, Naira S Khuroo, Digestive Diseases Centre, Dr. Khuroo's medical Clinic, Srinagar, Kashmir 190010, India.Mohammad S Khuroo, Naira S Khuroo, Digestive Diseases Centre, Dr. Khuroo's medical Clinic, Srinagar, Kashmir 190010, India.Mohammad S Khuroo, Naira S Khuroo, Digestive Diseases Centre, Dr. Khuroo's medical Clinic, Srinagar, Kashmir 190010, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27610014

Citation

Khuroo, Mohammad S., et al. "Hepatitis E: Discovery, Global Impact, Control and Cure." World Journal of Gastroenterology, vol. 22, no. 31, 2016, pp. 7030-45.
Khuroo MS, Khuroo MS, Khuroo NS. Hepatitis E: Discovery, global impact, control and cure. World J Gastroenterol. 2016;22(31):7030-45.
Khuroo, M. S., Khuroo, M. S., & Khuroo, N. S. (2016). Hepatitis E: Discovery, global impact, control and cure. World Journal of Gastroenterology, 22(31), 7030-45. https://doi.org/10.3748/wjg.v22.i31.7030
Khuroo MS, Khuroo MS, Khuroo NS. Hepatitis E: Discovery, Global Impact, Control and Cure. World J Gastroenterol. 2016 Aug 21;22(31):7030-45. PubMed PMID: 27610014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E: Discovery, global impact, control and cure. AU - Khuroo,Mohammad S, AU - Khuroo,Mehnaaz S, AU - Khuroo,Naira S, PY - 2016/03/26/received PY - 2016/06/10/revised PY - 2016/07/06/accepted PY - 2016/9/10/entrez PY - 2016/9/10/pubmed PY - 2017/4/20/medline KW - Communicable diseases KW - Discovery KW - Hepatitis E KW - Hepatitis E virus KW - Vaccine KW - Zoonosis SP - 7030 EP - 45 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 22 IS - 31 N2 - Hepatitis E was identified as an epidemic of non-A, non-B hepatitis from Kashmir, India in 1978. Hepatitis E virus (HEV), the etiological agent is the sole member of family Hepeviridae. The virus has marked heterogeneity and infects many animals like bats, camel, chicken, deer, boar, mongoose, pigs, rats, rabbit and cutthroat trout. Hepatitis E is a disease with a major global impact and has two distinct epidemiological patterns. Hepatitis E is an imperative health issue in developing nations, transmitted through sullied water and happens most every now in young adults. The disease is particularly severe during pregnancy and in people with underlying liver cirrhosis. Autochthonous hepatitis E is increasingly recognized in developed countries. The virus infects domestic pigs, wild boar and Sika deer in these countries. HEV infections in humans occur by eating the undercooked game flesh, raw liver from supermarkets and Figatelli sausages. Blood transfusion-associated HEV infections occur in many countries and screening of donors for HEV RNA is under consideration. Hepatitis E causes a number of extrahepatic diseases, including a wide spectrum of neurological syndromes. HEV genotype 3 causes prolonged viremia, chronic hepatitis, liver fibrosis and cirrhosis in organ transplant patients. The virus is amenable to ribavirin monotherapy and most patients clear the virus in a few weeks. Hepatitis E vaccine -239, marketed in China, has shown high efficacy with sustained protection for over four years. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/27610014/Hepatitis_E:_Discovery_global_impact_control_and_cure_ L2 - https://www.wjgnet.com/1007-9327/full/v22/i31/7030.htm DB - PRIME DP - Unbound Medicine ER -