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A Cross-Reactivity of Fenofibric Acid With MDMA DRI Assay.
Mil Med. 2016 09; 181(9):1013-5.MM

Abstract

BACKGROUND

Within the framework of routine fitness examinations, French Air Force military crew underwent urine testing for 3,4 methylenedioxymetamphetamine (MDMA [ecstasy]). The cross-reactivity of a dyslipidemic drug, fenofibrate, with an MDMA immunoassay was studied and confirmed on a large population sample.

METHODS

A 3-year retrospective study was performed on the MDMA DRI Ecstasy Assay on the Unicel DXC 600. In the event of positive test result, a confirmatory testing was carried out by gas chromatography/mass spectrometry (GC/MS) to establish the presence of MDMA. When analysis by GC/MS did not confirm the presence of MDMA, a false-positive result was suspected and the samples were analyzed by high-performance liquid chromatography-mass spectrometry to identify a potential interfering substance.

RESULTS

A total of 15,169 urine samples, from 7,803 patients, were tested for 3 years. Of the tested samples, 22 (0.15%) were positive by DRI Ecstasy Assay. None of them were positive by GC/MS. A cross-reactivity of fenofibrate's metabolite with MDMA using this assay was systematically found.

CONCLUSION

Fenofibrate's interference with MDMA immunoassay was confirmed. Fenofibrate being widely prescribed, physicians had to be alerted that this treatment could lead to false-positive results.

Authors+Show Affiliations

Laboratory of Biochemistry, Percy French Military Teaching Hospital, 101 Avenue Henri Barbusse, 92140 Clamart, France.Laboratory of Biochemistry, Percy French Military Teaching Hospital, 101 Avenue Henri Barbusse, 92140 Clamart, France.Laboratory of Biochemistry, Percy French Military Teaching Hospital, 101 Avenue Henri Barbusse, 92140 Clamart, France.Laboratory of Biochemistry, Percy French Military Teaching Hospital, 101 Avenue Henri Barbusse, 92140 Clamart, France.Laboratory of Biochemistry, Percy French Military Teaching Hospital, 101 Avenue Henri Barbusse, 92140 Clamart, France.Laboratory of Biology, Val de Grace French Military Teaching Hospital, 74 Boulevard Port Royal, 75230 Paris Cedex 09, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27612346

Citation

Bugier, Sarah, et al. "A Cross-Reactivity of Fenofibric Acid With MDMA DRI Assay." Military Medicine, vol. 181, no. 9, 2016, pp. 1013-5.
Bugier S, Garcia-Hejl C, Vest P, et al. A Cross-Reactivity of Fenofibric Acid With MDMA DRI Assay. Mil Med. 2016;181(9):1013-5.
Bugier, S., Garcia-Hejl, C., Vest, P., Plantamura, J., Chianea, D., & Renard, C. (2016). A Cross-Reactivity of Fenofibric Acid With MDMA DRI Assay. Military Medicine, 181(9), 1013-5. https://doi.org/10.7205/MILMED-D-15-00442
Bugier S, et al. A Cross-Reactivity of Fenofibric Acid With MDMA DRI Assay. Mil Med. 2016;181(9):1013-5. PubMed PMID: 27612346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Cross-Reactivity of Fenofibric Acid With MDMA DRI Assay. AU - Bugier,Sarah, AU - Garcia-Hejl,Carine, AU - Vest,Philippe, AU - Plantamura,Julie, AU - Chianea,Denis, AU - Renard,Christophe, PY - 2016/9/10/entrez PY - 2016/9/10/pubmed PY - 2018/1/18/medline SP - 1013 EP - 5 JF - Military medicine JO - Mil Med VL - 181 IS - 9 N2 - BACKGROUND: Within the framework of routine fitness examinations, French Air Force military crew underwent urine testing for 3,4 methylenedioxymetamphetamine (MDMA [ecstasy]). The cross-reactivity of a dyslipidemic drug, fenofibrate, with an MDMA immunoassay was studied and confirmed on a large population sample. METHODS: A 3-year retrospective study was performed on the MDMA DRI Ecstasy Assay on the Unicel DXC 600. In the event of positive test result, a confirmatory testing was carried out by gas chromatography/mass spectrometry (GC/MS) to establish the presence of MDMA. When analysis by GC/MS did not confirm the presence of MDMA, a false-positive result was suspected and the samples were analyzed by high-performance liquid chromatography-mass spectrometry to identify a potential interfering substance. RESULTS: A total of 15,169 urine samples, from 7,803 patients, were tested for 3 years. Of the tested samples, 22 (0.15%) were positive by DRI Ecstasy Assay. None of them were positive by GC/MS. A cross-reactivity of fenofibrate's metabolite with MDMA using this assay was systematically found. CONCLUSION: Fenofibrate's interference with MDMA immunoassay was confirmed. Fenofibrate being widely prescribed, physicians had to be alerted that this treatment could lead to false-positive results. SN - 1930-613X UR - https://www.unboundmedicine.com/medline/citation/27612346/A_Cross_Reactivity_of_Fenofibric_Acid_With_MDMA_DRI_Assay_ L2 - https://academic.oup.com/milmed/article-lookup/doi/10.7205/MILMED-D-15-00442 DB - PRIME DP - Unbound Medicine ER -