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Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes.
Sci Rep 2016; 6:33147SR

Abstract

Mitochondrial uncoupling protein 2 (UCP2) can affect oxidative stress levels. UCP2 polymorphisms are associated with leukocyte telomere length (LTL) in Type 2 Diabetes, which also induces considerable background oxidative stress. The effects of UCP2 polymorphisms on LTL in populations without diabetes have not been well described. Our aims are to evaluate the interaction between LTL and UCP2 polymorphisms in 950 subjects without diabetes. The monochrome multiplex quantitative PCR method was used to measure relative LTL. Taqman SNP genotyping assay was applied to genotypes for UCP2 rs659366 and rs660339. We found shorter LTL associated with increased age (P < 0.001) and triglyceride levels (P = 0.041). After adjustment for cardiovascular risk factors, rs659336 GG genotype carriers demonstrated a shorter LTL (1.257 ± 0.186), compared to GA carriers (1.288 ± 0.230, P = 0.022) and AA carriers (1.314 ± 0.253, P = 0.002). LTL was shorter in the CC rs660339 genotype (1.254 ± 0.187) compared to TT (1.297 ± 0.242, P = 0.007) and CT carriers (1.292 ± 0.229, P = 0.016). The T allele of rs660339 is associated with a longer LTL of approximately 0.04 compared to CC homozygotes. Thus, UCP2 rs659366 A allele and rs660339 T allele are both related to longer LTL in subjects without diabetes, independent of cardiovascular risk factors.

Authors+Show Affiliations

University of New South Wales, Rural Clinical School, Sydney, Australia.University of Melbourne, Rural Clinical School, Shepparton, Australia. Western Sydney University, School of Medicine, Sydney, Australia.University of Sydney, Discipline of Pathology and Bosch Institute, Sydney, Australia.University of New South Wales, Rural Clinical School, Sydney, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27615599

Citation

Zhou, Yuling, et al. "Interactions Between UCP2 SNPs and Telomere Length Exist in the Absence of Diabetes or Pre-diabetes." Scientific Reports, vol. 6, 2016, p. 33147.
Zhou Y, Simmons D, Hambly BD, et al. Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes. Sci Rep. 2016;6:33147.
Zhou, Y., Simmons, D., Hambly, B. D., & McLachlan, C. S. (2016). Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes. Scientific Reports, 6, p. 33147. doi:10.1038/srep33147.
Zhou Y, et al. Interactions Between UCP2 SNPs and Telomere Length Exist in the Absence of Diabetes or Pre-diabetes. Sci Rep. 2016 09 12;6:33147. PubMed PMID: 27615599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes. AU - Zhou,Yuling, AU - Simmons,David, AU - Hambly,Brett D, AU - McLachlan,Craig S, Y1 - 2016/09/12/ PY - 2016/04/06/received PY - 2016/08/18/accepted PY - 2016/9/13/entrez PY - 2016/9/13/pubmed PY - 2018/6/7/medline SP - 33147 EP - 33147 JF - Scientific reports JO - Sci Rep VL - 6 N2 - Mitochondrial uncoupling protein 2 (UCP2) can affect oxidative stress levels. UCP2 polymorphisms are associated with leukocyte telomere length (LTL) in Type 2 Diabetes, which also induces considerable background oxidative stress. The effects of UCP2 polymorphisms on LTL in populations without diabetes have not been well described. Our aims are to evaluate the interaction between LTL and UCP2 polymorphisms in 950 subjects without diabetes. The monochrome multiplex quantitative PCR method was used to measure relative LTL. Taqman SNP genotyping assay was applied to genotypes for UCP2 rs659366 and rs660339. We found shorter LTL associated with increased age (P < 0.001) and triglyceride levels (P = 0.041). After adjustment for cardiovascular risk factors, rs659336 GG genotype carriers demonstrated a shorter LTL (1.257 ± 0.186), compared to GA carriers (1.288 ± 0.230, P = 0.022) and AA carriers (1.314 ± 0.253, P = 0.002). LTL was shorter in the CC rs660339 genotype (1.254 ± 0.187) compared to TT (1.297 ± 0.242, P = 0.007) and CT carriers (1.292 ± 0.229, P = 0.016). The T allele of rs660339 is associated with a longer LTL of approximately 0.04 compared to CC homozygotes. Thus, UCP2 rs659366 A allele and rs660339 T allele are both related to longer LTL in subjects without diabetes, independent of cardiovascular risk factors. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/27615599/Interactions_between_UCP2_SNPs_and_telomere_length_exist_in_the_absence_of_diabetes_or_pre_diabetes_ L2 - http://dx.doi.org/10.1038/srep33147 DB - PRIME DP - Unbound Medicine ER -