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A Phenolic Extract Obtained from Methyl Jasmonate-Treated Strawberries Enhances Apoptosis in a Human Cervical Cancer Cell Line.
Nutr Cancer. 2016 10; 68(7):1140-50.NC

Abstract

In the present study, we evaluated the effect of methyl jasmonate (MeJA) treatment on strawberry phenolic composition. Strawberry extracts contain a mixture of phenolic compounds possessing several biological properties. We demonstrated that these extracts were more effective in inducing apoptosis in HeLa cells compared to phenolic preparations derived from untreated strawberries. Treatment of strawberries with 0.5% MeJA resulted in increased polyphenols content (from 7.4 to 8.6 mM quercetin equivalents) and antioxidant properties (from 3.9 to 4.6 mM quercetin equivalents). The identification and quantification of phenolic compounds by liquid chromatography-mass spectrometry in the strawberry extracts showed that cyanidin glucoside, pelargonidin glucoside, and ellagic glucoside acid were significantly higher in strawberries treated with MeJA. Phenolic extracts from MeJA-treated strawberries significantly decreased the cell viability in HeLa cells, compared to extracts derived from untreated fruits. We hypothesized that the enhanced apoptotic activity of MeJA-treated strawberries was due to a synergistic or additive effect of different phenolic compounds present in the extract, rather than the activity of a single molecule.

Authors+Show Affiliations

a Institute of Food Sciences, National Research Council , Avellino , Italy.b Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Consejo Superior de Investigaciones Científicas (CSIC) , Juan de la Cierva 3, Madrid , Spain.a Institute of Food Sciences, National Research Council , Avellino , Italy.b Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Consejo Superior de Investigaciones Científicas (CSIC) , Juan de la Cierva 3, Madrid , Spain.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27618150

Citation

Spagnuolo, Carmela, et al. "A Phenolic Extract Obtained From Methyl Jasmonate-Treated Strawberries Enhances Apoptosis in a Human Cervical Cancer Cell Line." Nutrition and Cancer, vol. 68, no. 7, 2016, pp. 1140-50.
Spagnuolo C, Flores G, Russo GL, et al. A Phenolic Extract Obtained from Methyl Jasmonate-Treated Strawberries Enhances Apoptosis in a Human Cervical Cancer Cell Line. Nutr Cancer. 2016;68(7):1140-50.
Spagnuolo, C., Flores, G., Russo, G. L., & Ruiz Del Castillo, M. L. (2016). A Phenolic Extract Obtained from Methyl Jasmonate-Treated Strawberries Enhances Apoptosis in a Human Cervical Cancer Cell Line. Nutrition and Cancer, 68(7), 1140-50. https://doi.org/10.1080/01635581.2016.1208831
Spagnuolo C, et al. A Phenolic Extract Obtained From Methyl Jasmonate-Treated Strawberries Enhances Apoptosis in a Human Cervical Cancer Cell Line. Nutr Cancer. 2016;68(7):1140-50. PubMed PMID: 27618150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Phenolic Extract Obtained from Methyl Jasmonate-Treated Strawberries Enhances Apoptosis in a Human Cervical Cancer Cell Line. AU - Spagnuolo,Carmela, AU - Flores,Gema, AU - Russo,Gian Luigi, AU - Ruiz Del Castillo,Maria Luisa, Y1 - 2016/08/11/ PY - 2016/9/13/entrez PY - 2016/9/13/pubmed PY - 2017/12/20/medline SP - 1140 EP - 50 JF - Nutrition and cancer JO - Nutr Cancer VL - 68 IS - 7 N2 - In the present study, we evaluated the effect of methyl jasmonate (MeJA) treatment on strawberry phenolic composition. Strawberry extracts contain a mixture of phenolic compounds possessing several biological properties. We demonstrated that these extracts were more effective in inducing apoptosis in HeLa cells compared to phenolic preparations derived from untreated strawberries. Treatment of strawberries with 0.5% MeJA resulted in increased polyphenols content (from 7.4 to 8.6 mM quercetin equivalents) and antioxidant properties (from 3.9 to 4.6 mM quercetin equivalents). The identification and quantification of phenolic compounds by liquid chromatography-mass spectrometry in the strawberry extracts showed that cyanidin glucoside, pelargonidin glucoside, and ellagic glucoside acid were significantly higher in strawberries treated with MeJA. Phenolic extracts from MeJA-treated strawberries significantly decreased the cell viability in HeLa cells, compared to extracts derived from untreated fruits. We hypothesized that the enhanced apoptotic activity of MeJA-treated strawberries was due to a synergistic or additive effect of different phenolic compounds present in the extract, rather than the activity of a single molecule. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/27618150/A_Phenolic_Extract_Obtained_from_Methyl_Jasmonate_Treated_Strawberries_Enhances_Apoptosis_in_a_Human_Cervical_Cancer_Cell_Line_ DB - PRIME DP - Unbound Medicine ER -