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CCR5-Δ32 gene polymorphism is associated with retinopathy in patients with type 1 diabetes.
Mol Cell Endocrinol 2017; 439:256-260MC

Abstract

AIM

The aim of the study was to assess the relationship between the CCR5-Δ32 polymorphism and the risk of diabetic retinopathy (DR) in patients with DM1.

METHODS

We examined 420 patients and 350 healthy controls. The analysis concerned CCR5-Δ32 polymorphism as well as levels of serum inflammatory markers (CRP, TNF-α), adhesion molecules (VCAM, ICAM-1, ICAM-3) and CCR5 ligand (MCP-1).

RESULTS

We found a negative association between DM1 and Δ32 allele. Moreover, the frequency of Δ32 allele was higher in a group with DR in comparison to control subjects without this complication. We also found that Δ32 carriers had the highest levels of: HbA1c, inflammatory markers, adhesion molecules and CCR5 ligand.

CONCLUSIONS

The findings of our studies suggest that the CCR5-Δ32 polymorphism is associated with DM1 such that the Δ32 allele protects against the development of DM1 and increases the risk of DR in patients who have already developed the disease.

Authors+Show Affiliations

Department of Immunology, Medical University of Gdańsk, ul. Dębinki 1, 80-211 Gdańsk, Poland. Electronic address: bartosz@gumed.edu.pl.Department of Immunology, Medical University of Gdańsk, ul. Dębinki 1, 80-211 Gdańsk, Poland.Department of Immunology, Medical University of Gdańsk, ul. Dębinki 1, 80-211 Gdańsk, Poland.Department of Immunology, Medical University of Gdańsk, ul. Dębinki 1, 80-211 Gdańsk, Poland.Department of Immunology, Medical University of Gdańsk, ul. Dębinki 1, 80-211 Gdańsk, Poland.Chair & Clinics of Paediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27619405

Citation

Słomiński, Bartosz, et al. "CCR5-Δ32 Gene Polymorphism Is Associated With Retinopathy in Patients With Type 1 Diabetes." Molecular and Cellular Endocrinology, vol. 439, 2017, pp. 256-260.
Słomiński B, Ławrynowicz U, Myśliwska J, et al. CCR5-Δ32 gene polymorphism is associated with retinopathy in patients with type 1 diabetes. Mol Cell Endocrinol. 2017;439:256-260.
Słomiński, B., Ławrynowicz, U., Myśliwska, J., Ryba-Stanisławowska, M., Skrzypkowska, M., & Brandt, A. (2017). CCR5-Δ32 gene polymorphism is associated with retinopathy in patients with type 1 diabetes. Molecular and Cellular Endocrinology, 439, pp. 256-260. doi:10.1016/j.mce.2016.09.009.
Słomiński B, et al. CCR5-Δ32 Gene Polymorphism Is Associated With Retinopathy in Patients With Type 1 Diabetes. Mol Cell Endocrinol. 2017 01 5;439:256-260. PubMed PMID: 27619405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CCR5-Δ32 gene polymorphism is associated with retinopathy in patients with type 1 diabetes. AU - Słomiński,Bartosz, AU - Ławrynowicz,Urszula, AU - Myśliwska,Jolanta, AU - Ryba-Stanisławowska,Monika, AU - Skrzypkowska,Maria, AU - Brandt,Agnieszka, Y1 - 2016/09/09/ PY - 2016/04/28/received PY - 2016/09/07/revised PY - 2016/09/09/accepted PY - 2016/9/14/pubmed PY - 2017/11/29/medline PY - 2016/9/14/entrez KW - CCR5-Δ 32 polymorphism KW - Diabetes retinopathy KW - Inflammation SP - 256 EP - 260 JF - Molecular and cellular endocrinology JO - Mol. Cell. Endocrinol. VL - 439 N2 - AIM: The aim of the study was to assess the relationship between the CCR5-Δ32 polymorphism and the risk of diabetic retinopathy (DR) in patients with DM1. METHODS: We examined 420 patients and 350 healthy controls. The analysis concerned CCR5-Δ32 polymorphism as well as levels of serum inflammatory markers (CRP, TNF-α), adhesion molecules (VCAM, ICAM-1, ICAM-3) and CCR5 ligand (MCP-1). RESULTS: We found a negative association between DM1 and Δ32 allele. Moreover, the frequency of Δ32 allele was higher in a group with DR in comparison to control subjects without this complication. We also found that Δ32 carriers had the highest levels of: HbA1c, inflammatory markers, adhesion molecules and CCR5 ligand. CONCLUSIONS: The findings of our studies suggest that the CCR5-Δ32 polymorphism is associated with DM1 such that the Δ32 allele protects against the development of DM1 and increases the risk of DR in patients who have already developed the disease. SN - 1872-8057 UR - https://www.unboundmedicine.com/medline/citation/27619405/CCR5_Δ32_gene_polymorphism_is_associated_with_retinopathy_in_patients_with_type_1_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-7207(16)30374-4 DB - PRIME DP - Unbound Medicine ER -