Tags

Type your tag names separated by a space and hit enter

Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats.
Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec; 389(12):1325-1332.NS

Abstract

Sodium hydrosulfide (NaHS) has presented antihypertensive and antioxidant effects and may reduce circulating soluble fms-like tyrosine kinase-1 (sFlt-1). We examined whether NaHS prevents maternal and fetal detrimental changes in a model of hypertension in pregnancy induced by N(G)-nitro-L-arginine methyl ester (L-NAME). Forty pregnant rats were divided into four groups (n = 10 per group): Norm-Preg, Preg + NaHS, HTN-Preg, or HTN-Preg + NaHS. Systolic blood pressure (SBP), number of viable fetuses, litter size, pups, and placentae weights were recorded. Circulating plasma sFlt-1, vascular endothelial growth factor (VEGF), myeloperoxidase (MPO), trolox equivalent antioxidant capacity (TEAC) levels, and biochemical determinants of nitric oxide (NO) formation were assessed. SBP values were elevated in the HTN-Preg group on gestational days 16, 18, and 20. However, HTN-Preg + NaHS group presented lower SBP values on days 18 and 20. Lower number of viable fetuses and litter size were found only in HTN-Preg group compared to other. Reductions in placental weight were found in HTN-Preg and HTN-Preg + NaHS groups. Increases in fetal weight were found only in Preg + NaHS group. Increases in circulating sFlt-1 and VEGF levels were observed only in HTN-Preg group compared to other. Higher MPO and lower TEAC plasma levels were found in HTN-Preg + NaHS and HTN-Preg groups. NO was diminished in HTN-Preg animals, and NaHS treatment increased NO levels only in hypertensive pregnant animals. Treatment with NaHS prevents hypertension in pregnancy and concomitantly reduces circulating plasma sFlt-1 and VEGF levels; this correlates with improved litter size with more viable fetuses and increase in NO levels. However, these beneficial effects presented no relation with oxidative stress.

Authors+Show Affiliations

Department of Pharmacology, Biosciences Institute of Botucatu, Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, 18.618-970, Botucatu, Sao Paulo, Brazil.Department of Pharmacology, Biosciences Institute of Botucatu, Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, 18.618-970, Botucatu, Sao Paulo, Brazil.Department of Pharmacology, Biosciences Institute of Botucatu, Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, 18.618-970, Botucatu, Sao Paulo, Brazil.Department of Pharmacology, Biosciences Institute of Botucatu, Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, 18.618-970, Botucatu, Sao Paulo, Brazil.Department of Pharmacology, Biosciences Institute of Botucatu, Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, 18.618-970, Botucatu, Sao Paulo, Brazil. carlosjunior@ibb.unesp.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27620880

Citation

Possomato-Vieira, Jose Sergio, et al. "Sodium Hydrosulfide Prevents Hypertension and Increases in Vascular Endothelial Growth Factor and Soluble Fms-like Tyrosine Kinase-1 in Hypertensive Pregnant Rats." Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 389, no. 12, 2016, pp. 1325-1332.
Possomato-Vieira JS, Gonçalves-Rizzi VH, Graça TU, et al. Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats. Naunyn Schmiedebergs Arch Pharmacol. 2016;389(12):1325-1332.
Possomato-Vieira, J. S., Gonçalves-Rizzi, V. H., Graça, T. U., Nascimento, R. A., & Dias-Junior, C. A. (2016). Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 389(12), 1325-1332.
Possomato-Vieira JS, et al. Sodium Hydrosulfide Prevents Hypertension and Increases in Vascular Endothelial Growth Factor and Soluble Fms-like Tyrosine Kinase-1 in Hypertensive Pregnant Rats. Naunyn Schmiedebergs Arch Pharmacol. 2016;389(12):1325-1332. PubMed PMID: 27620880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats. AU - Possomato-Vieira,Jose Sergio, AU - Gonçalves-Rizzi,Victor Hugo, AU - Graça,Tamiris Uracs Sales, AU - Nascimento,Regina Aparecida, AU - Dias-Junior,Carlos A, Y1 - 2016/09/12/ PY - 2016/03/19/received PY - 2016/08/29/accepted PY - 2016/9/14/pubmed PY - 2017/2/24/medline PY - 2016/9/14/entrez KW - Hydrogen sulfide donor KW - N(G)-nitro-L-arginine methyl ester KW - Preeclampsia KW - Rats SP - 1325 EP - 1332 JF - Naunyn-Schmiedeberg's archives of pharmacology JO - Naunyn Schmiedebergs Arch Pharmacol VL - 389 IS - 12 N2 - Sodium hydrosulfide (NaHS) has presented antihypertensive and antioxidant effects and may reduce circulating soluble fms-like tyrosine kinase-1 (sFlt-1). We examined whether NaHS prevents maternal and fetal detrimental changes in a model of hypertension in pregnancy induced by N(G)-nitro-L-arginine methyl ester (L-NAME). Forty pregnant rats were divided into four groups (n = 10 per group): Norm-Preg, Preg + NaHS, HTN-Preg, or HTN-Preg + NaHS. Systolic blood pressure (SBP), number of viable fetuses, litter size, pups, and placentae weights were recorded. Circulating plasma sFlt-1, vascular endothelial growth factor (VEGF), myeloperoxidase (MPO), trolox equivalent antioxidant capacity (TEAC) levels, and biochemical determinants of nitric oxide (NO) formation were assessed. SBP values were elevated in the HTN-Preg group on gestational days 16, 18, and 20. However, HTN-Preg + NaHS group presented lower SBP values on days 18 and 20. Lower number of viable fetuses and litter size were found only in HTN-Preg group compared to other. Reductions in placental weight were found in HTN-Preg and HTN-Preg + NaHS groups. Increases in fetal weight were found only in Preg + NaHS group. Increases in circulating sFlt-1 and VEGF levels were observed only in HTN-Preg group compared to other. Higher MPO and lower TEAC plasma levels were found in HTN-Preg + NaHS and HTN-Preg groups. NO was diminished in HTN-Preg animals, and NaHS treatment increased NO levels only in hypertensive pregnant animals. Treatment with NaHS prevents hypertension in pregnancy and concomitantly reduces circulating plasma sFlt-1 and VEGF levels; this correlates with improved litter size with more viable fetuses and increase in NO levels. However, these beneficial effects presented no relation with oxidative stress. SN - 1432-1912 UR - https://www.unboundmedicine.com/medline/citation/27620880/Sodium_hydrosulfide_prevents_hypertension_and_increases_in_vascular_endothelial_growth_factor_and_soluble_fms_like_tyrosine_kinase_1_in_hypertensive_pregnant_rats_ L2 - https://dx.doi.org/10.1007/s00210-016-1296-5 DB - PRIME DP - Unbound Medicine ER -