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Antibiotic resistance in Burkholderia species.
Drug Resist Updat. 2016 09; 28:82-90.DR

Abstract

The genus Burkholderia comprises metabolically diverse and adaptable Gram-negative bacteria, which thrive in often adversarial environments. A few members of the genus are prominent opportunistic pathogens. These include Burkholderia mallei and Burkholderia pseudomallei of the B. pseudomallei complex, which cause glanders and melioidosis, respectively. Burkholderia cenocepacia, Burkholderia multivorans, and Burkholderia vietnamiensis belong to the Burkholderia cepacia complex and affect mostly cystic fibrosis patients. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance. The first line of defense against antimicrobials in Burkholderia species is the outer membrane penetration barrier. Most Burkholderia contain a modified lipopolysaccharide that causes intrinsic polymyxin resistance. Contributing to reduced drug penetration are restrictive porin proteins. Efflux pumps of the resistance nodulation cell division family are major players in Burkholderia multidrug resistance. Third and fourth generation β-lactam antibiotics are seminal for treatment of Burkholderia infections, but therapeutic efficacy is compromised by expression of several β-lactamases and ceftazidime target mutations. Altered DNA gyrase and dihydrofolate reductase targets cause fluoroquinolone and trimethoprim resistance, respectively. Although antibiotic resistance hampers therapy of Burkholderia infections, the characterization of resistance mechanisms lags behind other non-enteric Gram-negative pathogens, especially ESKAPE bacteria such as Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa.

Authors+Show Affiliations

Department of Molecular Genetics and Microbiology, College of Medicine, Emerging Pathogens Institute and Institute for Therapeutic Innovation, University of Florida, Gainesville, FL, USA; Department of Microbiology Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.Department of Molecular Genetics and Microbiology, College of Medicine, Emerging Pathogens Institute and Institute for Therapeutic Innovation, University of Florida, Gainesville, FL, USA. Electronic address: hschweizer@ufl.edu.

Pub Type(s)

Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

27620956

Citation

Rhodes, Katherine A., and Herbert P. Schweizer. "Antibiotic Resistance in Burkholderia Species." Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, vol. 28, 2016, pp. 82-90.
Rhodes KA, Schweizer HP. Antibiotic resistance in Burkholderia species. Drug Resist Updat. 2016;28:82-90.
Rhodes, K. A., & Schweizer, H. P. (2016). Antibiotic resistance in Burkholderia species. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, 28, 82-90. https://doi.org/10.1016/j.drup.2016.07.003
Rhodes KA, Schweizer HP. Antibiotic Resistance in Burkholderia Species. Drug Resist Updat. 2016;28:82-90. PubMed PMID: 27620956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic resistance in Burkholderia species. AU - Rhodes,Katherine A, AU - Schweizer,Herbert P, Y1 - 2016/07/30/ PY - 2016/9/14/entrez PY - 2016/9/14/pubmed PY - 2018/1/20/medline KW - Antibiotics resistance KW - Burkholderia KW - Burkholderia cepacia complex KW - Glanders KW - Melioidosis SP - 82 EP - 90 JF - Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy JO - Drug Resist Updat VL - 28 N2 - The genus Burkholderia comprises metabolically diverse and adaptable Gram-negative bacteria, which thrive in often adversarial environments. A few members of the genus are prominent opportunistic pathogens. These include Burkholderia mallei and Burkholderia pseudomallei of the B. pseudomallei complex, which cause glanders and melioidosis, respectively. Burkholderia cenocepacia, Burkholderia multivorans, and Burkholderia vietnamiensis belong to the Burkholderia cepacia complex and affect mostly cystic fibrosis patients. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance. The first line of defense against antimicrobials in Burkholderia species is the outer membrane penetration barrier. Most Burkholderia contain a modified lipopolysaccharide that causes intrinsic polymyxin resistance. Contributing to reduced drug penetration are restrictive porin proteins. Efflux pumps of the resistance nodulation cell division family are major players in Burkholderia multidrug resistance. Third and fourth generation β-lactam antibiotics are seminal for treatment of Burkholderia infections, but therapeutic efficacy is compromised by expression of several β-lactamases and ceftazidime target mutations. Altered DNA gyrase and dihydrofolate reductase targets cause fluoroquinolone and trimethoprim resistance, respectively. Although antibiotic resistance hampers therapy of Burkholderia infections, the characterization of resistance mechanisms lags behind other non-enteric Gram-negative pathogens, especially ESKAPE bacteria such as Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. SN - 1532-2084 UR - https://www.unboundmedicine.com/medline/citation/27620956/Antibiotic_resistance_in_Burkholderia_species_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-7646(16)30034-6 DB - PRIME DP - Unbound Medicine ER -