Tags

Type your tag names separated by a space and hit enter

Effect of alcohol and alcoholic beverages on nonstimulated pancreatic secretion in humans.
Pancreas. 1989; 4(4):486-91.P

Abstract

The effects of alcoholic beverages on pancreatic secretion, blood trypsin levels, the release of gastrin and cholecystokinin were studied and compared with those of an alcohol and a glucose solution. Studies were done on six healthy male volunteers. The trypsin level was measured in the duodenal aspirate, while blood trypsin and gastrin levels were measured by radioimmunoassay and the cholecystokinin level was measured by bioassay. Studies were done on 5 different days, and on each day, the effects of either a glucose solution; an alcohol solution; or wine, beer, and gin solutions infused into the stomach were compared. The glucose solution stimulated trypsin secretion (a threefold increase above the basal measure) and the release of cholecystokinin without changes in the blood trypsin level. Blood alcohol levels, after the alcohol solution and all alcoholic beverages, were similar, and subjects showed mild symptoms of intoxication. Pancreatic enzyme secretion and trypsin blood levels were not significantly affected by either alcohol or the alcoholic beverages. Wine and beer caused significant release of gastrin and cholecystokinin. Under the conditions of this study, which reproduce those of excessive alcohol drinking, alcohol and alcoholic beverages did not stimulate pancreatic enzyme secretion, although wine and beer increased the release of gastrin and cholecystokinin. We conclude that alcohol and alcoholic beverages do not affect nonstimulated pancreatic enzyme secretion.

Authors+Show Affiliations

Gastroenterology Section, Los Angeles County-University of Southern California Medical Center.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2762276

Citation

Hajnal, F, et al. "Effect of Alcohol and Alcoholic Beverages On Nonstimulated Pancreatic Secretion in Humans." Pancreas, vol. 4, no. 4, 1989, pp. 486-91.
Hajnal F, Flores MC, Valenzuela JE. Effect of alcohol and alcoholic beverages on nonstimulated pancreatic secretion in humans. Pancreas. 1989;4(4):486-91.
Hajnal, F., Flores, M. C., & Valenzuela, J. E. (1989). Effect of alcohol and alcoholic beverages on nonstimulated pancreatic secretion in humans. Pancreas, 4(4), 486-91.
Hajnal F, Flores MC, Valenzuela JE. Effect of Alcohol and Alcoholic Beverages On Nonstimulated Pancreatic Secretion in Humans. Pancreas. 1989;4(4):486-91. PubMed PMID: 2762276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of alcohol and alcoholic beverages on nonstimulated pancreatic secretion in humans. AU - Hajnal,F, AU - Flores,M C, AU - Valenzuela,J E, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 486 EP - 91 JF - Pancreas JO - Pancreas VL - 4 IS - 4 N2 - The effects of alcoholic beverages on pancreatic secretion, blood trypsin levels, the release of gastrin and cholecystokinin were studied and compared with those of an alcohol and a glucose solution. Studies were done on six healthy male volunteers. The trypsin level was measured in the duodenal aspirate, while blood trypsin and gastrin levels were measured by radioimmunoassay and the cholecystokinin level was measured by bioassay. Studies were done on 5 different days, and on each day, the effects of either a glucose solution; an alcohol solution; or wine, beer, and gin solutions infused into the stomach were compared. The glucose solution stimulated trypsin secretion (a threefold increase above the basal measure) and the release of cholecystokinin without changes in the blood trypsin level. Blood alcohol levels, after the alcohol solution and all alcoholic beverages, were similar, and subjects showed mild symptoms of intoxication. Pancreatic enzyme secretion and trypsin blood levels were not significantly affected by either alcohol or the alcoholic beverages. Wine and beer caused significant release of gastrin and cholecystokinin. Under the conditions of this study, which reproduce those of excessive alcohol drinking, alcohol and alcoholic beverages did not stimulate pancreatic enzyme secretion, although wine and beer increased the release of gastrin and cholecystokinin. We conclude that alcohol and alcoholic beverages do not affect nonstimulated pancreatic enzyme secretion. SN - 0885-3177 UR - https://www.unboundmedicine.com/medline/citation/2762276/Effect_of_alcohol_and_alcoholic_beverages_on_nonstimulated_pancreatic_secretion_in_humans_ L2 - https://doi.org/10.1097/00006676-198908000-00014 DB - PRIME DP - Unbound Medicine ER -