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Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range.
Invest Ophthalmol Vis Sci. 2016 Sep 01; 57(11):4815-23.IO

Abstract

PURPOSE

We tested the hypothesis that the macular ganglion cell layer (GCL) thickness demonstrates a stronger structure-function (SF) relationship and extends the useful range of macular measurements compared with combined macular inner layer or full thickness.

METHODS

Ninety-eight glaucomatous eyes and eight normal eyes with macular spectral domain optical coherence tomography (SD-OCT) volume scans and 10-2 visual fields were enrolled. Inner plexiform layer (IPL), GCL, macular retinal nerve fiber layer (mRNFL), ganglion cell-inner plexiform layer (GCIPL), ganglion cell complex (GCC), and full thickness (FT) measurements were calculated for 8 × 8 arrays of 3° superpixels. Main outcome measures were local structure-function relationships between macular superpixels and corresponding sensitivities on 10-2 fields after adjusting for ganglion cell displacement, dynamic range of measurements, and the change point (total deviation value where macular parameters reached measurement floor).

RESULTS

Median (interquartile range [IQR]) mean deviation was -7.2 (-11.6 to -3.2) dB in glaucoma eyes. Strength of SF relationships was highest for GCIPL, GCL, GCC, and IPL (ρ = 0.635, 0.627, 0.621, and 0.577, respectively; P ≤ 0.046 for comparisons against GCIPL). Highest SF correlations coincided with the peak of GCL thickness, where the dynamic range was widest for FT (81.1 μm), followed by GCC (65.7 μm), GCIPL (54.9 μm), GCL (35.2 μm), mRNFL (27.5 μm), and IPL (20.9 μm). Change points were similar for all macular parameters (-7.8 to -8.9 dB).

CONCLUSIONS

GCIPL, GCL, and GCC demonstrated comparable SF relationships while FT, GCC, and GCIPL had the widest dynamic range. Measurement of GCL did not extend the range of useful structural measurements. Measuring GCL does not provide any advantage for detection of progression with current SD-OCT technology.

Authors+Show Affiliations

Glaucoma Division Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States 2Eye Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.Glaucoma Division Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States.Glaucoma Division Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States.Glaucoma Division Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States.Glaucoma Division Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States 3Department of Biostatistics, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, United States.Department of Biostatistics, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, United States.Glaucoma Division Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States.Glaucoma Division Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States.Glaucoma Division Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27623336

Citation

Miraftabi, Arezoo, et al. "Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range." Investigative Ophthalmology & Visual Science, vol. 57, no. 11, 2016, pp. 4815-23.
Miraftabi A, Amini N, Morales E, et al. Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range. Invest Ophthalmol Vis Sci. 2016;57(11):4815-23.
Miraftabi, A., Amini, N., Morales, E., Henry, S., Yu, F., Afifi, A., Coleman, A. L., Caprioli, J., & Nouri-Mahdavi, K. (2016). Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range. Investigative Ophthalmology & Visual Science, 57(11), 4815-23. https://doi.org/10.1167/iovs.16-19648
Miraftabi A, et al. Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range. Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4815-23. PubMed PMID: 27623336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range. AU - Miraftabi,Arezoo, AU - Amini,Navid, AU - Morales,Esteban, AU - Henry,Sharon, AU - Yu,Fei, AU - Afifi,Abdolmonem, AU - Coleman,Anne L, AU - Caprioli,Joseph, AU - Nouri-Mahdavi,Kouros, PY - 2016/9/14/entrez PY - 2016/9/14/pubmed PY - 2017/5/27/medline SP - 4815 EP - 23 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 57 IS - 11 N2 - PURPOSE: We tested the hypothesis that the macular ganglion cell layer (GCL) thickness demonstrates a stronger structure-function (SF) relationship and extends the useful range of macular measurements compared with combined macular inner layer or full thickness. METHODS: Ninety-eight glaucomatous eyes and eight normal eyes with macular spectral domain optical coherence tomography (SD-OCT) volume scans and 10-2 visual fields were enrolled. Inner plexiform layer (IPL), GCL, macular retinal nerve fiber layer (mRNFL), ganglion cell-inner plexiform layer (GCIPL), ganglion cell complex (GCC), and full thickness (FT) measurements were calculated for 8 × 8 arrays of 3° superpixels. Main outcome measures were local structure-function relationships between macular superpixels and corresponding sensitivities on 10-2 fields after adjusting for ganglion cell displacement, dynamic range of measurements, and the change point (total deviation value where macular parameters reached measurement floor). RESULTS: Median (interquartile range [IQR]) mean deviation was -7.2 (-11.6 to -3.2) dB in glaucoma eyes. Strength of SF relationships was highest for GCIPL, GCL, GCC, and IPL (ρ = 0.635, 0.627, 0.621, and 0.577, respectively; P ≤ 0.046 for comparisons against GCIPL). Highest SF correlations coincided with the peak of GCL thickness, where the dynamic range was widest for FT (81.1 μm), followed by GCC (65.7 μm), GCIPL (54.9 μm), GCL (35.2 μm), mRNFL (27.5 μm), and IPL (20.9 μm). Change points were similar for all macular parameters (-7.8 to -8.9 dB). CONCLUSIONS: GCIPL, GCL, and GCC demonstrated comparable SF relationships while FT, GCC, and GCIPL had the widest dynamic range. Measurement of GCL did not extend the range of useful structural measurements. Measuring GCL does not provide any advantage for detection of progression with current SD-OCT technology. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/27623336/Macular_SD_OCT_Outcome_Measures:_Comparison_of_Local_Structure_Function_Relationships_and_Dynamic_Range_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.16-19648 DB - PRIME DP - Unbound Medicine ER -