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Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies.

Abstract

Quantification of the association between the intake of selenium and risk of pancreatic cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of selenium intake with the risk of pancreatic cancer. Pertinent studies were identified by a search of PubMed and Web of Knowledge to July 2016. The random-effect model was used. Sensitivity analysis and publication bias were conducted. Data from six studies including 1424 pancreatic cancer cases were used in this meta-analysis. Pooled results suggested that highest selenium intake amount compared with lowest amount was significantly associated with the risk of pancreatic cancer [summary relative risk (RR)=0.659, 95% confidence interval (CI)=0.489-0.889, I2=47.6%]. The associations were significant both in case-control studies [RR=0.618, 95%CI=0.399-0.956, I2=59.1%] and Americas [RR=0.570, 95%CI=0.357-0.909, I2=65.6%]. No publication bias was found. Our analysis suggested that the higher intake of selenium might reduce the risk of pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.

    ,

    Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.

    ,

    Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.

    ,

    Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.

    ,

    Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.

    Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China liangls123@sina.com.

    Source

    Bioscience reports 36:5 2016 10 pg

    MeSH

    Case-Control Studies
    Diet
    Humans
    Pancreatic Neoplasms
    Risk Factors
    Selenium

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    27623938

    Citation

    Wang, Lei, et al. "Association Between Selenium Intake and the Risk of Pancreatic Cancer: a Meta-analysis of Observational Studies." Bioscience Reports, vol. 36, no. 5, 2016.
    Wang L, Wang J, Liu X, et al. Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies. Biosci Rep. 2016;36(5).
    Wang, L., Wang, J., Liu, X., Liu, Q., Zhang, G., & Liang, L. (2016). Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies. Bioscience Reports, 36(5).
    Wang L, et al. Association Between Selenium Intake and the Risk of Pancreatic Cancer: a Meta-analysis of Observational Studies. Biosci Rep. 2016;36(5) PubMed PMID: 27623938.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies. AU - Wang,Lei, AU - Wang,Jianfeng, AU - Liu,Xudong, AU - Liu,Qian, AU - Zhang,Guozhuan, AU - Liang,Lishuang, Y1 - 2016/10/14/ PY - 2016/08/20/received PY - 2016/09/13/accepted PY - 2016/9/15/pubmed PY - 2017/12/1/medline PY - 2016/9/15/entrez KW - meta-analysis KW - pancreatic cancer KW - selenium JF - Bioscience reports JO - Biosci. Rep. VL - 36 IS - 5 N2 - Quantification of the association between the intake of selenium and risk of pancreatic cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of selenium intake with the risk of pancreatic cancer. Pertinent studies were identified by a search of PubMed and Web of Knowledge to July 2016. The random-effect model was used. Sensitivity analysis and publication bias were conducted. Data from six studies including 1424 pancreatic cancer cases were used in this meta-analysis. Pooled results suggested that highest selenium intake amount compared with lowest amount was significantly associated with the risk of pancreatic cancer [summary relative risk (RR)=0.659, 95% confidence interval (CI)=0.489-0.889, I2=47.6%]. The associations were significant both in case-control studies [RR=0.618, 95%CI=0.399-0.956, I2=59.1%] and Americas [RR=0.570, 95%CI=0.357-0.909, I2=65.6%]. No publication bias was found. Our analysis suggested that the higher intake of selenium might reduce the risk of pancreatic cancer. SN - 1573-4935 UR - https://www.unboundmedicine.com/medline/citation/27623938/Association_between_selenium_intake_and_the_risk_of_pancreatic_cancer:_a_meta_analysis_of_observational_studies_ L2 - http://www.bioscirep.org/cgi/pmidlookup?view=long&pmid=27623938 DB - PRIME DP - Unbound Medicine ER -