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Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies.
Biosci Rep 2016; 36(5)BR

Abstract

Quantification of the association between the intake of selenium and risk of pancreatic cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of selenium intake with the risk of pancreatic cancer. Pertinent studies were identified by a search of PubMed and Web of Knowledge to July 2016. The random-effect model was used. Sensitivity analysis and publication bias were conducted. Data from six studies including 1424 pancreatic cancer cases were used in this meta-analysis. Pooled results suggested that highest selenium intake amount compared with lowest amount was significantly associated with the risk of pancreatic cancer [summary relative risk (RR)=0.659, 95% confidence interval (CI)=0.489-0.889, I2=47.6%]. The associations were significant both in case-control studies [RR=0.618, 95%CI=0.399-0.956, I2=59.1%] and Americas [RR=0.570, 95%CI=0.357-0.909, I2=65.6%]. No publication bias was found. Our analysis suggested that the higher intake of selenium might reduce the risk of pancreatic cancer.

Authors+Show Affiliations

Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China.Department of pain, Qilu Hospital of Shandong University, Ji'nan, Shandong 250000, P.R. China liangls123@sina.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

27623938

Citation

Wang, Lei, et al. "Association Between Selenium Intake and the Risk of Pancreatic Cancer: a Meta-analysis of Observational Studies." Bioscience Reports, vol. 36, no. 5, 2016.
Wang L, Wang J, Liu X, et al. Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies. Biosci Rep. 2016;36(5).
Wang, L., Wang, J., Liu, X., Liu, Q., Zhang, G., & Liang, L. (2016). Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies. Bioscience Reports, 36(5).
Wang L, et al. Association Between Selenium Intake and the Risk of Pancreatic Cancer: a Meta-analysis of Observational Studies. Biosci Rep. 2016;36(5) PubMed PMID: 27623938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between selenium intake and the risk of pancreatic cancer: a meta-analysis of observational studies. AU - Wang,Lei, AU - Wang,Jianfeng, AU - Liu,Xudong, AU - Liu,Qian, AU - Zhang,Guozhuan, AU - Liang,Lishuang, Y1 - 2016/10/14/ PY - 2016/08/20/received PY - 2016/09/13/accepted PY - 2016/9/15/pubmed PY - 2017/12/1/medline PY - 2016/9/15/entrez KW - meta-analysis KW - pancreatic cancer KW - selenium JF - Bioscience reports JO - Biosci. Rep. VL - 36 IS - 5 N2 - Quantification of the association between the intake of selenium and risk of pancreatic cancer is still conflicting. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of selenium intake with the risk of pancreatic cancer. Pertinent studies were identified by a search of PubMed and Web of Knowledge to July 2016. The random-effect model was used. Sensitivity analysis and publication bias were conducted. Data from six studies including 1424 pancreatic cancer cases were used in this meta-analysis. Pooled results suggested that highest selenium intake amount compared with lowest amount was significantly associated with the risk of pancreatic cancer [summary relative risk (RR)=0.659, 95% confidence interval (CI)=0.489-0.889, I2=47.6%]. The associations were significant both in case-control studies [RR=0.618, 95%CI=0.399-0.956, I2=59.1%] and Americas [RR=0.570, 95%CI=0.357-0.909, I2=65.6%]. No publication bias was found. Our analysis suggested that the higher intake of selenium might reduce the risk of pancreatic cancer. SN - 1573-4935 UR - https://www.unboundmedicine.com/medline/citation/27623938/Association_between_selenium_intake_and_the_risk_of_pancreatic_cancer:_a_meta_analysis_of_observational_studies_ L2 - http://www.bioscirep.org/cgi/pmidlookup?view=long&pmid=27623938 DB - PRIME DP - Unbound Medicine ER -