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Commercial sunscreen formulations: UVB irradiation stability and effect on UVB irradiation-induced skin oxidative stress and inflammation.
J Photochem Photobiol B. 2016 Oct; 163:413-20.JP

Abstract

Evidence shows that sunscreens undergo degradation processes induced by UV irradiation forming free radicals, which reduces skin protection. In this regard, the biological effects of three commercial sunscreen formulations upon UVB irradiation in the skin were investigated. The three formulations had in common the presence of benzophenone-3 added with octyl methoxycinnamate or octyl salycilate or both, which are regular UV filters in sunscreens. The results show that formulations F1 and F2 presented partial degradation upon UVB irradiation. Formulations F1 and F2 presented higher skin penetration profiles than F3. None of the formulations avoided UVB irradiation-induced GSH depletion, but inhibited reduction of SOD activity, suggesting the tested formulations did not present as a major mechanism inhibiting all UVB irradiation-triggered oxidative stress pathways. The formulations avoided the increase of myeloperoxidase activity and cytokine production (IL-1β and TNF-α), but with different levels of protection in relation to the IL-1β release. Concluding, UVB irradiation can reduce the stability of sunscreens, which in turn, present the undesirable properties of reaching viable skin. Additionally, the same SPF does not mean that different sunscreens will present the same biological effects as SPF is solely based on a skin erythema response. This found opens up perspectives to consider additional studies to reach highly safe sunscreens.

Authors+Show Affiliations

Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, 14040-903, Ribeirão Preto, São Paulo, Brazil. Electronic address: fernandampvilela@gmail.com.Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, 14040-903, Ribeirão Preto, São Paulo, Brazil.Farmacore Biotecnologia LTDA, Rua Edson Souto, 728, Lagoinha, 14095-250, Ribeirão Preto, São Paulo, Brazil.Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina-UEL, Avenida Robert Koch, 60, Hospital Universitário, 86039-440 Londrina, Paraná, Brazil.Departamento de Ciências Patológicas, Universidade Estadual de Londrina-UEL, Rodovia Celso Garcia Cid, Km 380, PR445, 86057-970 Londrina, Paraná, Brazil.Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes, 14050-490, Ribeirão Preto, São Paulo, Brazil.Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, 14040-903, Ribeirão Preto, São Paulo, Brazil. Electronic address: magika@fcfrp.usp.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27627683

Citation

Vilela, Fernanda M P., et al. "Commercial Sunscreen Formulations: UVB Irradiation Stability and Effect On UVB Irradiation-induced Skin Oxidative Stress and Inflammation." Journal of Photochemistry and Photobiology. B, Biology, vol. 163, 2016, pp. 413-20.
Vilela FM, Oliveira FM, Vicentini FT, et al. Commercial sunscreen formulations: UVB irradiation stability and effect on UVB irradiation-induced skin oxidative stress and inflammation. J Photochem Photobiol B. 2016;163:413-20.
Vilela, F. M., Oliveira, F. M., Vicentini, F. T., Casagrande, R., Verri, W. A., Cunha, T. M., & Fonseca, M. J. (2016). Commercial sunscreen formulations: UVB irradiation stability and effect on UVB irradiation-induced skin oxidative stress and inflammation. Journal of Photochemistry and Photobiology. B, Biology, 163, 413-20. https://doi.org/10.1016/j.jphotobiol.2016.09.007
Vilela FM, et al. Commercial Sunscreen Formulations: UVB Irradiation Stability and Effect On UVB Irradiation-induced Skin Oxidative Stress and Inflammation. J Photochem Photobiol B. 2016;163:413-20. PubMed PMID: 27627683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Commercial sunscreen formulations: UVB irradiation stability and effect on UVB irradiation-induced skin oxidative stress and inflammation. AU - Vilela,Fernanda M P, AU - Oliveira,Franciane M, AU - Vicentini,Fabiana T M C, AU - Casagrande,Rubia, AU - Verri,Waldiceu A,Jr AU - Cunha,Thiago M, AU - Fonseca,Maria J V, Y1 - 2016/09/05/ PY - 2016/02/26/received PY - 2016/09/01/revised PY - 2016/09/03/accepted PY - 2016/9/15/entrez PY - 2016/9/15/pubmed PY - 2017/3/18/medline KW - Inflammation KW - Oxidative stress KW - Photostability KW - Sunscreens KW - UVB SP - 413 EP - 20 JF - Journal of photochemistry and photobiology. B, Biology JO - J Photochem Photobiol B VL - 163 N2 - Evidence shows that sunscreens undergo degradation processes induced by UV irradiation forming free radicals, which reduces skin protection. In this regard, the biological effects of three commercial sunscreen formulations upon UVB irradiation in the skin were investigated. The three formulations had in common the presence of benzophenone-3 added with octyl methoxycinnamate or octyl salycilate or both, which are regular UV filters in sunscreens. The results show that formulations F1 and F2 presented partial degradation upon UVB irradiation. Formulations F1 and F2 presented higher skin penetration profiles than F3. None of the formulations avoided UVB irradiation-induced GSH depletion, but inhibited reduction of SOD activity, suggesting the tested formulations did not present as a major mechanism inhibiting all UVB irradiation-triggered oxidative stress pathways. The formulations avoided the increase of myeloperoxidase activity and cytokine production (IL-1β and TNF-α), but with different levels of protection in relation to the IL-1β release. Concluding, UVB irradiation can reduce the stability of sunscreens, which in turn, present the undesirable properties of reaching viable skin. Additionally, the same SPF does not mean that different sunscreens will present the same biological effects as SPF is solely based on a skin erythema response. This found opens up perspectives to consider additional studies to reach highly safe sunscreens. SN - 1873-2682 UR - https://www.unboundmedicine.com/medline/citation/27627683/Commercial_sunscreen_formulations:_UVB_irradiation_stability_and_effect_on_UVB_irradiation_induced_skin_oxidative_stress_and_inflammation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1011-1344(16)30117-8 DB - PRIME DP - Unbound Medicine ER -