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Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders.
J Mol Neurosci. 2016 Nov; 60(3):298-304.JM

Abstract

Tau and α-Synuclein (α-Syn) are abundant brain proteins with distinct biological functions. Findings suggest that interactions between α-Syn and tau at the cellular level cause disruption of cytoskeletal organization, axonal transport defects, and aberrant synaptic organization. The ability of tau and α-Syn to affect each other directly or indirectly might contribute to the overlap in the clinical and pathological features of tauopathies and synucleinopathies. The interactions between α-Syn and tau, and the underlying molecular pathogenic mechanisms, including induction and spread of protein aggregates, still deserve further investigation.

Authors+Show Affiliations

Li X
Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150001, China.
James S
Oxidation Biology Unit, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria, 3052, Australia. simon.james@florey.edu.au.
Lei P
Oxidation Biology Unit, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria, 3052, Australia. peng.lei@scu.edu.cn. Department of Neurology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China. peng.lei@scu.edu.cn.

MeSH

Alzheimer DiseaseAnimalsHumansParkinson DiseaseProtein BindingProtein Processing, Post-TranslationalSynapsesalpha-Synucleintau Proteins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27629562

Citation

Li, Xuling, et al. "Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders." Journal of Molecular Neuroscience : MN, vol. 60, no. 3, 2016, pp. 298-304.
Li X, James S, Lei P. Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders. J Mol Neurosci. 2016;60(3):298-304.
Li, X., James, S., & Lei, P. (2016). Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders. Journal of Molecular Neuroscience : MN, 60(3), 298-304.
Li X, James S, Lei P. Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders. J Mol Neurosci. 2016;60(3):298-304. PubMed PMID: 27629562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders. AU - Li,Xuling, AU - James,Simon, AU - Lei,Peng, Y1 - 2016/09/15/ PY - 2016/08/22/received PY - 2016/08/30/accepted PY - 2016/9/16/pubmed PY - 2017/3/24/medline PY - 2016/9/16/entrez KW - Alzheimer’s disease KW - Neurodegeneration KW - Parkinson’s disease KW - Tau KW - α-Synuclein SP - 298 EP - 304 JF - Journal of molecular neuroscience : MN JO - J Mol Neurosci VL - 60 IS - 3 N2 - Tau and α-Synuclein (α-Syn) are abundant brain proteins with distinct biological functions. Findings suggest that interactions between α-Syn and tau at the cellular level cause disruption of cytoskeletal organization, axonal transport defects, and aberrant synaptic organization. The ability of tau and α-Syn to affect each other directly or indirectly might contribute to the overlap in the clinical and pathological features of tauopathies and synucleinopathies. The interactions between α-Syn and tau, and the underlying molecular pathogenic mechanisms, including induction and spread of protein aggregates, still deserve further investigation. SN - 1559-1166 UR - https://www.unboundmedicine.com/medline/citation/27629562/Interactions_Between_α_Synuclein_and_Tau_Protein:_Implications_to_Neurodegenerative_Disorders_ DB - PRIME DP - Unbound Medicine ER -