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Cerebral and non-cerebral coenurosis: on the genotypic and phenotypic diversity of Taenia multiceps.
Parasitol Res. 2016 Dec; 115(12):4543-4558.PR

Abstract

We characterised the causative agents of cerebral and non-cerebral coenurosis in livestock by determining the mitochondrial genotypes and morphological phenotypes of 52 Taenia multiceps isolates from a wide geographical range in Europe, Africa, and western Asia. Three studies were conducted: (1) a morphological comparison of the rostellar hooks of cerebral and non-cerebral cysts of sheep and goats, (2) a morphological comparison of adult worms experimentally produced in dogs, and (3) a molecular analysis of three partial mitochondrial genes (nad1, cox1, and 12S rRNA) of the same isolates. No significant morphological or genetic differences were associated with the species of the intermediate host. Adult parasites originating from cerebral and non-cerebral cysts differed morphologically, e.g. the shape of the small hooks and the distribution of the testes in the mature proglottids. The phylogenetic analysis of the mitochondrial haplotypes produced three distinct clusters: one cluster including both cerebral isolates from Greece and non-cerebral isolates from tropical and subtropical countries, and two clusters including cerebral isolates from Greece. The majority of the non-cerebral specimens clustered together but did not form a monophyletic group. No monophyletic groups were observed based on geography, although specimens from the same region tended to cluster. The clustering indicates high intraspecific diversity. The phylogenetic analysis suggests that all variants of T. multiceps can cause cerebral coenurosis in sheep (which may be the ancestral phenotype), and some variants, predominantly from one genetic cluster, acquired the additional capacity to produce non-cerebral forms in goats and more rarely in sheep.

Authors+Show Affiliations

Department of Parasitology, University of Hohenheim, Emil-Wolff-Str. 34, 70599, Stuttgart, Germany. gc@vet.uth.gr. Clinical Veterinary Medicine Department, School of Veterinary Medicine, University of Thessaly, P.O. Box 199, GR-43100, Karditsa, Greece. gc@vet.uth.gr.Department of Parasitology, University of Hohenheim, Emil-Wolff-Str. 34, 70599, Stuttgart, Germany.Department of Parasitology, University of Hohenheim, Emil-Wolff-Str. 34, 70599, Stuttgart, Germany.Department of Parasitology, University of Hohenheim, Emil-Wolff-Str. 34, 70599, Stuttgart, Germany.Department of Parasitology, University of Hohenheim, Emil-Wolff-Str. 34, 70599, Stuttgart, Germany.Department of Parasitology, University of Hohenheim, Emil-Wolff-Str. 34, 70599, Stuttgart, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27630103

Citation

Christodoulopoulos, Georgios, et al. "Cerebral and Non-cerebral Coenurosis: On the Genotypic and Phenotypic Diversity of Taenia Multiceps." Parasitology Research, vol. 115, no. 12, 2016, pp. 4543-4558.
Christodoulopoulos G, Dinkel A, Romig T, et al. Cerebral and non-cerebral coenurosis: on the genotypic and phenotypic diversity of Taenia multiceps. Parasitol Res. 2016;115(12):4543-4558.
Christodoulopoulos, G., Dinkel, A., Romig, T., Ebi, D., Mackenstedt, U., & Loos-Frank, B. (2016). Cerebral and non-cerebral coenurosis: on the genotypic and phenotypic diversity of Taenia multiceps. Parasitology Research, 115(12), 4543-4558.
Christodoulopoulos G, et al. Cerebral and Non-cerebral Coenurosis: On the Genotypic and Phenotypic Diversity of Taenia Multiceps. Parasitol Res. 2016;115(12):4543-4558. PubMed PMID: 27630103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral and non-cerebral coenurosis: on the genotypic and phenotypic diversity of Taenia multiceps. AU - Christodoulopoulos,Georgios, AU - Dinkel,Anke, AU - Romig,Thomas, AU - Ebi,Dennis, AU - Mackenstedt,Ute, AU - Loos-Frank,Brigitte, Y1 - 2016/09/15/ PY - 2016/08/04/received PY - 2016/09/02/accepted PY - 2016/9/16/pubmed PY - 2017/6/14/medline PY - 2016/9/16/entrez KW - Cerebral coenurosis KW - Mitochondrial genes KW - Molecular KW - Muscular coenurosis KW - Non-cerebral coenurosis KW - Taenia gaigeri KW - Taenia multiceps KW - Taenia skrjabini SP - 4543 EP - 4558 JF - Parasitology research JO - Parasitol. Res. VL - 115 IS - 12 N2 - We characterised the causative agents of cerebral and non-cerebral coenurosis in livestock by determining the mitochondrial genotypes and morphological phenotypes of 52 Taenia multiceps isolates from a wide geographical range in Europe, Africa, and western Asia. Three studies were conducted: (1) a morphological comparison of the rostellar hooks of cerebral and non-cerebral cysts of sheep and goats, (2) a morphological comparison of adult worms experimentally produced in dogs, and (3) a molecular analysis of three partial mitochondrial genes (nad1, cox1, and 12S rRNA) of the same isolates. No significant morphological or genetic differences were associated with the species of the intermediate host. Adult parasites originating from cerebral and non-cerebral cysts differed morphologically, e.g. the shape of the small hooks and the distribution of the testes in the mature proglottids. The phylogenetic analysis of the mitochondrial haplotypes produced three distinct clusters: one cluster including both cerebral isolates from Greece and non-cerebral isolates from tropical and subtropical countries, and two clusters including cerebral isolates from Greece. The majority of the non-cerebral specimens clustered together but did not form a monophyletic group. No monophyletic groups were observed based on geography, although specimens from the same region tended to cluster. The clustering indicates high intraspecific diversity. The phylogenetic analysis suggests that all variants of T. multiceps can cause cerebral coenurosis in sheep (which may be the ancestral phenotype), and some variants, predominantly from one genetic cluster, acquired the additional capacity to produce non-cerebral forms in goats and more rarely in sheep. SN - 1432-1955 UR - https://www.unboundmedicine.com/medline/citation/27630103/Cerebral_and_non_cerebral_coenurosis:_on_the_genotypic_and_phenotypic_diversity_of_Taenia_multiceps_ L2 - https://dx.doi.org/10.1007/s00436-016-5246-4 DB - PRIME DP - Unbound Medicine ER -