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[Diabetic neuropathy in dogs and cats--a bioptic electron microscopic study].
Tierarztl Prax. 1989; 17(2):177-88.TP

Abstract

Electron microscopic examination of peripheral nerves within dermal corium based upon skin biopsies (punch diameter = 6 mm) of chronic diabetic dogs and cats in comparison with normal controls revealed that more than 90% of the diabetic animals (31/34 dogs, 9/10 cats) had developed characteristic neuropathies. The main features were of axonal atrophy of myelinated and unmyelinated fibers, demyelination and - to a lesser degree - intraaxonal accumulation of glycogen (about 25%). In contrast with human diabetic polyneuropathy vascular basement membranes were throughout of normal appearance. Thickening of the perineural basement membranes were observed in a few canine cases only. Diagnostic procedures as well as questions on pathogenesis are discussed in detail.

Authors+Show Affiliations

Dahme E
Lehrstuhl für Allgemeine Pathologie und Neuropathologie, Tierärztlichen Fakultät der Ludwig-Maximilians-Universität München.
Hafner A
No affiliation info available
Reusch C
No affiliation info available
Schmidt P
No affiliation info available

MeSH

AnimalsAtrophyAxonsBasement MembraneBiopsyCat DiseasesCatsDemyelinating DiseasesDiabetic NeuropathiesDog DiseasesDogsFemaleMaleMicroscopy, ElectronMyelin SheathPeripheral NervesSkin

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

2763290

Citation

Dahme, E, et al. "[Diabetic Neuropathy in Dogs and Cats--a Bioptic Electron Microscopic Study]." Tierarztliche Praxis, vol. 17, no. 2, 1989, pp. 177-88.
Dahme E, Hafner A, Reusch C, et al. [Diabetic neuropathy in dogs and cats--a bioptic electron microscopic study]. Tierarztl Prax. 1989;17(2):177-88.
Dahme, E., Hafner, A., Reusch, C., & Schmidt, P. (1989). [Diabetic neuropathy in dogs and cats--a bioptic electron microscopic study]. Tierarztliche Praxis, 17(2), 177-88.
Dahme E, et al. [Diabetic Neuropathy in Dogs and Cats--a Bioptic Electron Microscopic Study]. Tierarztl Prax. 1989;17(2):177-88. PubMed PMID: 2763290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diabetic neuropathy in dogs and cats--a bioptic electron microscopic study]. AU - Dahme,E, AU - Hafner,A, AU - Reusch,C, AU - Schmidt,P, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 177 EP - 88 JF - Tierarztliche Praxis JO - Tierarztl Prax VL - 17 IS - 2 N2 - Electron microscopic examination of peripheral nerves within dermal corium based upon skin biopsies (punch diameter = 6 mm) of chronic diabetic dogs and cats in comparison with normal controls revealed that more than 90% of the diabetic animals (31/34 dogs, 9/10 cats) had developed characteristic neuropathies. The main features were of axonal atrophy of myelinated and unmyelinated fibers, demyelination and - to a lesser degree - intraaxonal accumulation of glycogen (about 25%). In contrast with human diabetic polyneuropathy vascular basement membranes were throughout of normal appearance. Thickening of the perineural basement membranes were observed in a few canine cases only. Diagnostic procedures as well as questions on pathogenesis are discussed in detail. SN - 0303-6286 UR - https://www.unboundmedicine.com/medline/citation/2763290/[Diabetic_neuropathy_in_dogs_and_cats__a_bioptic_electron_microscopic_study]_ DB - PRIME DP - Unbound Medicine ER -