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Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence.
Adv Nutr 2016; 7(5):889-904AN

Abstract

A growing body of evidence suggests that adherence to the Mediterranean diet (MD) may protect against cognitive decline and dementia. Many epidemiologic studies and several randomized controlled trials (RCTs) have found positive effects of the MD on cognitive function, but findings remain inconsistent. The aim of this systematic review was to provide an update on the current knowledge of the effects of the MD on cognitive function, cognitive impairment, Alzheimer disease (AD), and all-type dementia. Five databases were searched-PubMed, Embase, CINAHL, CENTRAL, and PsycINFO (1806 to 25 May 2015)-with the use of prespecified criteria. Human studies that were published in English without any restriction on study type, population assessed, intervention period, follow-up time, or publication date, and that examined the association between adherence to the MD and cognitive function or dementia symptoms (as measured by cognitive function tests), were included. Only primary publication types were included. Thirty-two studies from 25 unique cohorts, including 5 RCTs and 27 observational studies, met the inclusion criteria. The majority of studies showed that the MD was associated with improved cognitive function, a decreased risk of cognitive impairment or decreased risk of dementia, or AD. Three studies found no correlation between the MD and AD, 3 further studies found no association between the MD and cognitive impairment, and 5 studies found no association between the MD and cognitive function. There was large heterogeneity, and studies differed with regard to quality. Based on the findings and the limitations in study design, we conclude that adherence to the MD is associated with better cognitive performance. However, it should be noted that the majority of findings come from epidemiologic studies that provide evidence for a correlation between the MD and cognition but not for a cause-and-effect relation. More controlled trials are required to establish a causational relation.

Authors+Show Affiliations

Department of Nutrition and Dietetics, Division of Diabetes and Nutritional Sciences, King's College London, London, United Kingdom; and.Department of Nutrition and Dietetics, Division of Diabetes and Nutritional Sciences, King's College London, London, United Kingdom; and Department of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, Nicosia, Cyprus philippou.e@unic.ac.cy.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

27633105

Citation

Petersson, Sara Danuta, and Elena Philippou. "Mediterranean Diet, Cognitive Function, and Dementia: a Systematic Review of the Evidence." Advances in Nutrition (Bethesda, Md.), vol. 7, no. 5, 2016, pp. 889-904.
Petersson SD, Philippou E. Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence. Adv Nutr. 2016;7(5):889-904.
Petersson, S. D., & Philippou, E. (2016). Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence. Advances in Nutrition (Bethesda, Md.), 7(5), pp. 889-904. doi:10.3945/an.116.012138.
Petersson SD, Philippou E. Mediterranean Diet, Cognitive Function, and Dementia: a Systematic Review of the Evidence. Adv Nutr. 2016;7(5):889-904. PubMed PMID: 27633105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence. AU - Petersson,Sara Danuta, AU - Philippou,Elena, Y1 - 2016/09/15/ PY - 2016/9/17/entrez PY - 2016/9/17/pubmed PY - 2017/11/10/medline KW - Alzheimer disease KW - Mediterranean diet KW - cognitive function KW - cognitive impairment KW - dementia KW - dietary patterns KW - systematic review SP - 889 EP - 904 JF - Advances in nutrition (Bethesda, Md.) JO - Adv Nutr VL - 7 IS - 5 N2 - A growing body of evidence suggests that adherence to the Mediterranean diet (MD) may protect against cognitive decline and dementia. Many epidemiologic studies and several randomized controlled trials (RCTs) have found positive effects of the MD on cognitive function, but findings remain inconsistent. The aim of this systematic review was to provide an update on the current knowledge of the effects of the MD on cognitive function, cognitive impairment, Alzheimer disease (AD), and all-type dementia. Five databases were searched-PubMed, Embase, CINAHL, CENTRAL, and PsycINFO (1806 to 25 May 2015)-with the use of prespecified criteria. Human studies that were published in English without any restriction on study type, population assessed, intervention period, follow-up time, or publication date, and that examined the association between adherence to the MD and cognitive function or dementia symptoms (as measured by cognitive function tests), were included. Only primary publication types were included. Thirty-two studies from 25 unique cohorts, including 5 RCTs and 27 observational studies, met the inclusion criteria. The majority of studies showed that the MD was associated with improved cognitive function, a decreased risk of cognitive impairment or decreased risk of dementia, or AD. Three studies found no correlation between the MD and AD, 3 further studies found no association between the MD and cognitive impairment, and 5 studies found no association between the MD and cognitive function. There was large heterogeneity, and studies differed with regard to quality. Based on the findings and the limitations in study design, we conclude that adherence to the MD is associated with better cognitive performance. However, it should be noted that the majority of findings come from epidemiologic studies that provide evidence for a correlation between the MD and cognition but not for a cause-and-effect relation. More controlled trials are required to establish a causational relation. SN - 2156-5376 UR - https://www.unboundmedicine.com/medline/citation/27633105/Mediterranean_Diet_Cognitive_Function_and_Dementia:_A_Systematic_Review_of_the_Evidence_ L2 - https://academic.oup.com/advances/article-lookup/doi/10.3945/an.116.012138 DB - PRIME DP - Unbound Medicine ER -