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Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment?
Eur J Neurol 2017; 24(1):27-36EJ

Abstract

BACKGROUND AND PURPOSE

In multiple sclerosis (MS), depression is a common disorder whose pathophysiology is still debated. To gain insights into the pathophysiology of depression in MS, resting-state (RS) functional connectivity (FC) changes of the default mode network (DMN), salience network (SN) and executive control network (ECN) were assessed in a group of depressed MS (D-MS) patients and in appropriately matched control groups.

METHODS

Sixteen D-MS patients, 17 non-depressed MS (ND-MS) patients, 17 non-depressed healthy controls and 15 depressed subjects (D-S), age, sex and education matched, cognitively preserved and non-fatigued, were enrolled. All participants underwent a neuropsychological evaluation and RS functional magnetic resonance imaging study.

RESULTS

Comparing D-MS patients with D-S, within the DMN, a significant RS-FC suppression was found in the posterior cingulate cortex (PCC); comparing D-MS with ND-MS, FC was significantly increased in the anterior cingulate cortex and significantly reduced in the PCC. Within the SN increased FC in the right supramarginal gyrus and right middle frontal gyrus was found in D-MS patients compared to D-S and to ND-MS; within the ECN increased FC in the right inferior parietal cortex was found in D-MS patients compared to ND-MS patients.

CONCLUSIONS

In cognitively preserved D-MS patients, FC derangement occurs in the SN, ECN and DMN. In the latter, changes occurring both in the anterior cingulate cortex and PCC suggest that depression in MS may be linked to MS itself and, in particular, to a peculiar pattern of network abnormalities favored by MS pathology through disconnection mechanisms. Reduced FC in the PCC, similar to MS patients with cognitive impairment, suggests a functional link between depression and cognitive impairment in MS.

Authors+Show Affiliations

Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy. MRI Center 'SUN FISM', Neurological Institute for Diagnosis and Care 'Hermitage Capodimonte', Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.MRI Center 'SUN FISM', Neurological Institute for Diagnosis and Care 'Hermitage Capodimonte', Naples, Italy.MRI Center 'SUN FISM', Neurological Institute for Diagnosis and Care 'Hermitage Capodimonte', Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.Neuroradiology Service, Department of Radiology, Second University of Naples, Naples, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.Department of Medicine Surgery and Dentistry, University of Salerno, Salerno, Italy.Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy. MRI Center 'SUN FISM', Neurological Institute for Diagnosis and Care 'Hermitage Capodimonte', Naples, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27633185

Citation

Bonavita, S, et al. "Default Mode Network Changes in Multiple Sclerosis: a Link Between Depression and Cognitive Impairment?" European Journal of Neurology, vol. 24, no. 1, 2017, pp. 27-36.
Bonavita S, Sacco R, Esposito S, et al. Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment? Eur J Neurol. 2017;24(1):27-36.
Bonavita, S., Sacco, R., Esposito, S., d'Ambrosio, A., Della Corte, M., Corbo, D., ... Tedeschi, G. (2017). Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment? European Journal of Neurology, 24(1), pp. 27-36. doi:10.1111/ene.13112.
Bonavita S, et al. Default Mode Network Changes in Multiple Sclerosis: a Link Between Depression and Cognitive Impairment. Eur J Neurol. 2017;24(1):27-36. PubMed PMID: 27633185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment? AU - Bonavita,S, AU - Sacco,R, AU - Esposito,S, AU - d'Ambrosio,A, AU - Della Corte,M, AU - Corbo,D, AU - Docimo,R, AU - Gallo,A, AU - Lavorgna,L, AU - Cirillo,M, AU - Bisecco,A, AU - Esposito,F, AU - Tedeschi,G, Y1 - 2016/09/16/ PY - 2016/01/25/received PY - 2016/06/27/accepted PY - 2016/9/17/pubmed PY - 2018/1/4/medline PY - 2016/9/17/entrez KW - cognitive impairment KW - default mode network KW - depression KW - multiple sclerosis KW - resting state f-MRI SP - 27 EP - 36 JF - European journal of neurology JO - Eur. J. Neurol. VL - 24 IS - 1 N2 - BACKGROUND AND PURPOSE: In multiple sclerosis (MS), depression is a common disorder whose pathophysiology is still debated. To gain insights into the pathophysiology of depression in MS, resting-state (RS) functional connectivity (FC) changes of the default mode network (DMN), salience network (SN) and executive control network (ECN) were assessed in a group of depressed MS (D-MS) patients and in appropriately matched control groups. METHODS: Sixteen D-MS patients, 17 non-depressed MS (ND-MS) patients, 17 non-depressed healthy controls and 15 depressed subjects (D-S), age, sex and education matched, cognitively preserved and non-fatigued, were enrolled. All participants underwent a neuropsychological evaluation and RS functional magnetic resonance imaging study. RESULTS: Comparing D-MS patients with D-S, within the DMN, a significant RS-FC suppression was found in the posterior cingulate cortex (PCC); comparing D-MS with ND-MS, FC was significantly increased in the anterior cingulate cortex and significantly reduced in the PCC. Within the SN increased FC in the right supramarginal gyrus and right middle frontal gyrus was found in D-MS patients compared to D-S and to ND-MS; within the ECN increased FC in the right inferior parietal cortex was found in D-MS patients compared to ND-MS patients. CONCLUSIONS: In cognitively preserved D-MS patients, FC derangement occurs in the SN, ECN and DMN. In the latter, changes occurring both in the anterior cingulate cortex and PCC suggest that depression in MS may be linked to MS itself and, in particular, to a peculiar pattern of network abnormalities favored by MS pathology through disconnection mechanisms. Reduced FC in the PCC, similar to MS patients with cognitive impairment, suggests a functional link between depression and cognitive impairment in MS. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/27633185/Default_mode_network_changes_in_multiple_sclerosis:_a_link_between_depression_and_cognitive_impairment L2 - https://doi.org/10.1111/ene.13112 DB - PRIME DP - Unbound Medicine ER -