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Drug-induced photosensitivity: Photoallergic and phototoxic reactions.
Clin Dermatol. 2016 Sep-Oct; 34(5):571-81.CD

Abstract

Drug-induced photosensitivity refers to the development of cutaneous disease due to the interaction between a given chemical agent and sunlight. Photosensitivity reactions can be classified as phototoxic or photoallergic. Sometimes, there is an overlap between these two patterns, making their distinction particularly difficult for the clinician. We review the drugs that have been implicated as photosensitizers, the involved mechanism, and their clinical presentations. The main topical agents that cause contact photosensitivity are the nonsteroidal antiinflammatory drugs, whereas the main systemic drugs inducing photosensitivity are antimicrobials, nonsteroidal antiinflammatory agents, and cardiovascular drugs. Drug-induced photosensitivity remains a common clinical problem and is often underdiagnosed.

Authors+Show Affiliations

Department of Dermatovenereology, Hospital Distrital de Santarém EPE, Santarém, Portugal. Electronic address: Afilipe.monteiro@hds.min-saude.pt.Department of Dermatovenereology, Hospital Distrital de Santarém EPE, Santarém, Portugal.Department of Dermatovenereology, Hospital Distrital de Santarém EPE, Santarém, Portugal.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27638435

Citation

Monteiro, Ana Filipe, et al. "Drug-induced Photosensitivity: Photoallergic and Phototoxic Reactions." Clinics in Dermatology, vol. 34, no. 5, 2016, pp. 571-81.
Monteiro AF, Rato M, Martins C. Drug-induced photosensitivity: Photoallergic and phototoxic reactions. Clin Dermatol. 2016;34(5):571-81.
Monteiro, A. F., Rato, M., & Martins, C. (2016). Drug-induced photosensitivity: Photoallergic and phototoxic reactions. Clinics in Dermatology, 34(5), 571-81. https://doi.org/10.1016/j.clindermatol.2016.05.006
Monteiro AF, Rato M, Martins C. Drug-induced Photosensitivity: Photoallergic and Phototoxic Reactions. Clin Dermatol. 2016 Sep-Oct;34(5):571-81. PubMed PMID: 27638435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug-induced photosensitivity: Photoallergic and phototoxic reactions. AU - Monteiro,Ana Filipe, AU - Rato,Margarida, AU - Martins,César, Y1 - 2016/05/20/ PY - 2016/9/18/entrez PY - 2016/9/18/pubmed PY - 2017/5/4/medline SP - 571 EP - 81 JF - Clinics in dermatology JO - Clin. Dermatol. VL - 34 IS - 5 N2 - Drug-induced photosensitivity refers to the development of cutaneous disease due to the interaction between a given chemical agent and sunlight. Photosensitivity reactions can be classified as phototoxic or photoallergic. Sometimes, there is an overlap between these two patterns, making their distinction particularly difficult for the clinician. We review the drugs that have been implicated as photosensitizers, the involved mechanism, and their clinical presentations. The main topical agents that cause contact photosensitivity are the nonsteroidal antiinflammatory drugs, whereas the main systemic drugs inducing photosensitivity are antimicrobials, nonsteroidal antiinflammatory agents, and cardiovascular drugs. Drug-induced photosensitivity remains a common clinical problem and is often underdiagnosed. SN - 1879-1131 UR - https://www.unboundmedicine.com/medline/citation/27638435/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0738-081X(16)30138-9 DB - PRIME DP - Unbound Medicine ER -