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Chemical Composition and In Vitro Evaluation of Antimicrobial, Antioxidant and Antigerminative Properties of the Seed Oil from the Tunisian Endemic Ferula tunetana Pomel ex Batt.
Chem Biodivers. 2017 Jan; 14(1)CB

Abstract

Essential oil of the seeds from the endemic Tunisian plant Ferula tunetana Pomel ex Batt. was analyzed for its chemical composition and screened for its antimicrobial, antioxidant and antigerminative properties. The chemical composition of the isolated oil is reported for the first time. According to the GC/FID, GC/MS and 13 C-NMR analysis results; 18 compounds were identified accounting for 84.6% of the total oil. The chemical composition of this essential oil was characterized by the presence of a high proportion of monoterpene hydrocarbons (77.3%) followed by oxygenated sesquiterpenes (4.1%) and sesquiterpene hydrocarbons (3.2%). α-Pinene (39.8%), β-pinene (11.5%) and (Z)-β-ocimene (7.5%) were the predominant compounds. Moreover, the isolated oil was tested for its antimicrobial activity using the disc-diffusion and the microdilution assays against six Gram-positive and five Gram-negative bacteria as well as towards two Candida species. The isolated oil was tested also for its antioxidant activity against DPPH, ABTS, O2∙ and hydrogen peroxide (H2 O2), and for its antigerminative potential. It was found that it exhibited interesting antimicrobial activity against Salmonella typhimurium LT2 DT104 (inhibition zone (IZ) 16.2 ± 1.0 mm) and Bacillus cereus ATCC 14579 (IZ 15.8 ± 1.0 mm). However, it exerted a moderate antioxidant activity against H2 O2 (IC50 78.2 ± 2.98 μg/ml) and towards O2∙ (IC50 89.2 ± 3.82 μg/ml). The antigerminative effect of this oil was also evaluated in this work. Results showed a toxic effect.

Authors+Show Affiliations

Laboratory Heterocyclic Chemistry, Natural Products and é (LR11SE39), Team: Medicinal Chemistry and Natural Products and Reactivity, Faculty of Science of Monastir, University of Monastir, 5019, Monastir, Tunisia.Laboratory Heterocyclic Chemistry, Natural Products and é (LR11SE39), Team: Medicinal Chemistry and Natural Products and Reactivity, Faculty of Science of Monastir, University of Monastir, 5019, Monastir, Tunisia.Laboratory Heterocyclic Chemistry, Natural Products and é (LR11SE39), Team: Medicinal Chemistry and Natural Products and Reactivity, Faculty of Science of Monastir, University of Monastir, 5019, Monastir, Tunisia.UMR 6134 SPE, Equipe Chimie et Biomasse, Université de Corse-CNRS, Route des Sanguinaires, FR-20000, Ajaccio.Faculté de pharmacie de Toulouse, Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique UMR CNRS 5623, Université de Toulouse, Université Paul-Sabatier, 118 route de Narbonne, FR-31062, Toulouse.Laboratory Heterocyclic Chemistry, Natural Products and é (LR11SE39), Team: Medicinal Chemistry and Natural Products and Reactivity, Faculty of Science of Monastir, University of Monastir, 5019, Monastir, Tunisia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27638478

Citation

Znati, Mansour, et al. "Chemical Composition and in Vitro Evaluation of Antimicrobial, Antioxidant and Antigerminative Properties of the Seed Oil From the Tunisian Endemic Ferula Tunetana Pomel Ex Batt." Chemistry & Biodiversity, vol. 14, no. 1, 2017.
Znati M, Filali I, Jabrane A, et al. Chemical Composition and In Vitro Evaluation of Antimicrobial, Antioxidant and Antigerminative Properties of the Seed Oil from the Tunisian Endemic Ferula tunetana Pomel ex Batt. Chem Biodivers. 2017;14(1).
Znati, M., Filali, I., Jabrane, A., Casanova, J., Bouajila, J., & Ben Jannet, H. (2017). Chemical Composition and In Vitro Evaluation of Antimicrobial, Antioxidant and Antigerminative Properties of the Seed Oil from the Tunisian Endemic Ferula tunetana Pomel ex Batt. Chemistry & Biodiversity, 14(1). https://doi.org/10.1002/cbdv.201600116
Znati M, et al. Chemical Composition and in Vitro Evaluation of Antimicrobial, Antioxidant and Antigerminative Properties of the Seed Oil From the Tunisian Endemic Ferula Tunetana Pomel Ex Batt. Chem Biodivers. 2017;14(1) PubMed PMID: 27638478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical Composition and In Vitro Evaluation of Antimicrobial, Antioxidant and Antigerminative Properties of the Seed Oil from the Tunisian Endemic Ferula tunetana Pomel ex Batt. AU - Znati,Mansour, AU - Filali,Insaf, AU - Jabrane,Aymen, AU - Casanova,Joseph, AU - Bouajila,Jalloul, AU - Ben Jannet,Hichem, Y1 - 2016/12/20/ PY - 2016/04/07/received PY - 2016/09/14/accepted PY - 2016/9/18/pubmed PY - 2017/1/28/medline PY - 2016/9/18/entrez KW - Ferula tunetana KW - Antigerminative activities KW - Antimicrobial activities KW - Antioxidant activities KW - Chemical composition KW - Endemic KW - Seed oil JF - Chemistry & biodiversity JO - Chem Biodivers VL - 14 IS - 1 N2 - Essential oil of the seeds from the endemic Tunisian plant Ferula tunetana Pomel ex Batt. was analyzed for its chemical composition and screened for its antimicrobial, antioxidant and antigerminative properties. The chemical composition of the isolated oil is reported for the first time. According to the GC/FID, GC/MS and 13 C-NMR analysis results; 18 compounds were identified accounting for 84.6% of the total oil. The chemical composition of this essential oil was characterized by the presence of a high proportion of monoterpene hydrocarbons (77.3%) followed by oxygenated sesquiterpenes (4.1%) and sesquiterpene hydrocarbons (3.2%). α-Pinene (39.8%), β-pinene (11.5%) and (Z)-β-ocimene (7.5%) were the predominant compounds. Moreover, the isolated oil was tested for its antimicrobial activity using the disc-diffusion and the microdilution assays against six Gram-positive and five Gram-negative bacteria as well as towards two Candida species. The isolated oil was tested also for its antioxidant activity against DPPH, ABTS, O2∙ and hydrogen peroxide (H2 O2), and for its antigerminative potential. It was found that it exhibited interesting antimicrobial activity against Salmonella typhimurium LT2 DT104 (inhibition zone (IZ) 16.2 ± 1.0 mm) and Bacillus cereus ATCC 14579 (IZ 15.8 ± 1.0 mm). However, it exerted a moderate antioxidant activity against H2 O2 (IC50 78.2 ± 2.98 μg/ml) and towards O2∙ (IC50 89.2 ± 3.82 μg/ml). The antigerminative effect of this oil was also evaluated in this work. Results showed a toxic effect. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/27638478/Chemical_Composition_and_In_Vitro_Evaluation_of_Antimicrobial_Antioxidant_and_Antigerminative_Properties_of_the_Seed_Oil_from_the_Tunisian_Endemic_Ferula_tunetana_Pomel_ex_Batt_ L2 - https://doi.org/10.1002/cbdv.201600116 DB - PRIME DP - Unbound Medicine ER -