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[Degenerative DNA alterations in osteoarthritis].
Pathologe. 2016 Nov; 37(Suppl 2):223-228.P

Abstract

Osteoarthritis is a complex disease involving not only the cartilage but also the adjacent bone and the synovial membrane. The etiology of osteoarthritis involves multiple factors. Unlike secondary forms of osteoarthritis, which are the result of other diseases or excessive mechanical stress, the origins of primary forms of osteoarthritis lie within the cartilage. In primary osteoarthritis complex interactions of cytokines leading to a derangement of homeostasis have been discovered, which lead to a slow and progressive degeneration of the cartilage and bone, ultimately resulting in destruction of the joint. Damage to the cartilage matrix is caused by an increased activity of matrix metalloproteases induced by catabolic cytokines. One of the initial events triggering these processes might be degenerative DNA alterations causing local defects in multiple genes leading to an impaired function of chondrocytes and a phenotype similar to senescence.

Authors+Show Affiliations

Söder S
Pathologisches Institut, Universitätsklinikum Erlangen, Krankenhausstraβe. 12, 91054, Erlangen, Deutschland. stephan.soeder@uk-erlangen.de.

MeSH

Bone and BonesCartilage, ArticularCellular SenescenceChondrocytesCytokinesDNA DamageHumansMatrilin ProteinsMultigene FamilyOsteoarthritisPhenotypeSynovial Membrane

Pub Type(s)

Journal Article
Review

Language

ger

PubMed ID

27638529

Citation

Söder, S. "[Degenerative DNA Alterations in Osteoarthritis]." Der Pathologe, vol. 37, no. Suppl 2, 2016, pp. 223-228.
Söder S. [Degenerative DNA alterations in osteoarthritis]. Pathologe. 2016;37(Suppl 2):223-228.
Söder, S. (2016). [Degenerative DNA alterations in osteoarthritis]. Der Pathologe, 37(Suppl 2), 223-228.
Söder S. [Degenerative DNA Alterations in Osteoarthritis]. Pathologe. 2016;37(Suppl 2):223-228. PubMed PMID: 27638529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Degenerative DNA alterations in osteoarthritis]. A1 - Söder,S, PY - 2016/9/18/pubmed PY - 2017/10/11/medline PY - 2016/9/18/entrez KW - Cartilage matrix KW - Chondrocytes KW - Cytokines KW - Matrix metalloproteases KW - Senescence SP - 223 EP - 228 JF - Der Pathologe JO - Pathologe VL - 37 IS - Suppl 2 N2 - Osteoarthritis is a complex disease involving not only the cartilage but also the adjacent bone and the synovial membrane. The etiology of osteoarthritis involves multiple factors. Unlike secondary forms of osteoarthritis, which are the result of other diseases or excessive mechanical stress, the origins of primary forms of osteoarthritis lie within the cartilage. In primary osteoarthritis complex interactions of cytokines leading to a derangement of homeostasis have been discovered, which lead to a slow and progressive degeneration of the cartilage and bone, ultimately resulting in destruction of the joint. Damage to the cartilage matrix is caused by an increased activity of matrix metalloproteases induced by catabolic cytokines. One of the initial events triggering these processes might be degenerative DNA alterations causing local defects in multiple genes leading to an impaired function of chondrocytes and a phenotype similar to senescence. SN - 1432-1963 UR - https://www.unboundmedicine.com/medline/citation/27638529/[Degenerative_DNA_alterations_in_osteoarthritis]_ DB - PRIME DP - Unbound Medicine ER -