Tags

Type your tag names separated by a space and hit enter

Trace detection of tetrahydrocannabinol (THC) with a SERS-based capillary platform prepared by the in situ microwave synthesis of AgNPs.
Anal Chim Acta. 2016 Oct 05; 939:93-100.AC

Abstract

In the present study, an ultra-sensitive and highly reproducible novel SERS-based capillary platform was developed and utilized for the trace detection of tetrahydrocannabinol (THC). The approach combines the advantages of microwave-assisted nanoparticle synthesis, plasmonics and capillary forces. By employing a microwave-assisted preparation method, glass capillaries were reproducibly coated with silver nanoparticles in a batch fabrication process that required a processing time of 3 min without needing to use any pre-surface modifications or add surfactants. The coated capillaries exhibited an excellent SERS activity with a high reproducibility and enabled the detection of low concentrations of target molecules. At the same time, only a small amount of analyte and a short and simple incubation process was required. The developed platform was applied to the spectroscopic characterization of tetrahydrocannabinol (THC) and its identification at concentration levels down to 1 nM. Thus, a highly efficient detection system for practical applications, e.g., in drug monitoring/detection, is introduced, which can be fabricated at low cost by using microwave-assisted batch synthesis techniques.

Authors+Show Affiliations

Leibniz Institute of Photonic Technology Jena (IPHT), Jenaer BioChip Initiative, Albert-Einstein-Straβe 9, 07745 Jena, Germany; Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany; InfectoGnostics Forschungscampus Jena, Zentrum für Angewandte Forschung, Philosophenweg 7, 07743 Jena, Germany.Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany.Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.Leibniz Institute of Photonic Technology Jena (IPHT), Jenaer BioChip Initiative, Albert-Einstein-Straβe 9, 07745 Jena, Germany; Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany; InfectoGnostics Forschungscampus Jena, Zentrum für Angewandte Forschung, Philosophenweg 7, 07743 Jena, Germany.Leibniz Institute of Photonic Technology Jena (IPHT), Jenaer BioChip Initiative, Albert-Einstein-Straβe 9, 07745 Jena, Germany; Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany; InfectoGnostics Forschungscampus Jena, Zentrum für Angewandte Forschung, Philosophenweg 7, 07743 Jena, Germany. Electronic address: dana.cialla-may@uni-jena.de.Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany. Electronic address: s.hoeppener@uni-jena.de.Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany.Leibniz Institute of Photonic Technology Jena (IPHT), Jenaer BioChip Initiative, Albert-Einstein-Straβe 9, 07745 Jena, Germany; Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743 Jena, Germany; InfectoGnostics Forschungscampus Jena, Zentrum für Angewandte Forschung, Philosophenweg 7, 07743 Jena, Germany; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27639147

Citation

Yüksel, Sezin, et al. "Trace Detection of Tetrahydrocannabinol (THC) With a SERS-based Capillary Platform Prepared By the in Situ Microwave Synthesis of AgNPs." Analytica Chimica Acta, vol. 939, 2016, pp. 93-100.
Yüksel S, Schwenke AM, Soliveri G, et al. Trace detection of tetrahydrocannabinol (THC) with a SERS-based capillary platform prepared by the in situ microwave synthesis of AgNPs. Anal Chim Acta. 2016;939:93-100.
Yüksel, S., Schwenke, A. M., Soliveri, G., Ardizzone, S., Weber, K., Cialla-May, D., Hoeppener, S., Schubert, U. S., & Popp, J. (2016). Trace detection of tetrahydrocannabinol (THC) with a SERS-based capillary platform prepared by the in situ microwave synthesis of AgNPs. Analytica Chimica Acta, 939, 93-100. https://doi.org/10.1016/j.aca.2016.08.033
Yüksel S, et al. Trace Detection of Tetrahydrocannabinol (THC) With a SERS-based Capillary Platform Prepared By the in Situ Microwave Synthesis of AgNPs. Anal Chim Acta. 2016 Oct 5;939:93-100. PubMed PMID: 27639147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trace detection of tetrahydrocannabinol (THC) with a SERS-based capillary platform prepared by the in situ microwave synthesis of AgNPs. AU - Yüksel,Sezin, AU - Schwenke,Almut M, AU - Soliveri,Guido, AU - Ardizzone,Silvia, AU - Weber,Karina, AU - Cialla-May,Dana, AU - Hoeppener,Stephanie, AU - Schubert,Ulrich S, AU - Popp,Jürgen, Y1 - 2016/08/26/ PY - 2016/05/24/received PY - 2016/07/25/revised PY - 2016/08/20/accepted PY - 2016/9/18/entrez PY - 2016/9/18/pubmed PY - 2018/1/18/medline KW - Capillary KW - Drug monitoring KW - Microwave-assisted synthesis KW - SERS KW - THC SP - 93 EP - 100 JF - Analytica chimica acta JO - Anal Chim Acta VL - 939 N2 - In the present study, an ultra-sensitive and highly reproducible novel SERS-based capillary platform was developed and utilized for the trace detection of tetrahydrocannabinol (THC). The approach combines the advantages of microwave-assisted nanoparticle synthesis, plasmonics and capillary forces. By employing a microwave-assisted preparation method, glass capillaries were reproducibly coated with silver nanoparticles in a batch fabrication process that required a processing time of 3 min without needing to use any pre-surface modifications or add surfactants. The coated capillaries exhibited an excellent SERS activity with a high reproducibility and enabled the detection of low concentrations of target molecules. At the same time, only a small amount of analyte and a short and simple incubation process was required. The developed platform was applied to the spectroscopic characterization of tetrahydrocannabinol (THC) and its identification at concentration levels down to 1 nM. Thus, a highly efficient detection system for practical applications, e.g., in drug monitoring/detection, is introduced, which can be fabricated at low cost by using microwave-assisted batch synthesis techniques. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/27639147/Trace_detection_of_tetrahydrocannabinol__THC__with_a_SERS_based_capillary_platform_prepared_by_the_in_situ_microwave_synthesis_of_AgNPs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(16)30976-X DB - PRIME DP - Unbound Medicine ER -