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In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies.
J Allergy Clin Immunol. 2017 May; 139(5):1508-1517.JA

Abstract

BACKGROUND

Studies of the associations between in utero 25-hydroxyvitamin D (25[OH]D) exposure and risk of childhood asthma, wheeze, and respiratory tract infections are inconsistent and inconclusive.

OBJECTIVES

We sought to assess associations between 25(OH)D levels in cord blood or maternal venous blood and risk of offspring's asthma, wheeze, and respiratory tract infections.

METHODS

Data were derived from PubMed, Embase, Google Scholar, references from relevant articles, and de novo results from published studies until December 2015. A random-effects meta-analysis was conducted among 16 birth cohort studies.

RESULTS

Comparing the highest with the lowest category of 25(OH)D levels, the pooled odds ratios were 0.84 (95% CI, 0.70-1.01; P = .064) for asthma, 0.77 (95% CI, 0.58-1.03; P = .083) for wheeze, and 0.85 (95% CI, 0.66-1.09; P = .187) for respiratory tract infections. The observed inverse association for wheeze was more pronounced and became statistically significant in the studies that measured 25(OH)D levels in cord blood (0.43; 95% CI, 0.29-0.62; P < .001).

CONCLUSIONS

Accumulated evidence generated from this meta-analysis suggests that increased in utero exposure to 25(OH)D is inversely associated with the risk of asthma and wheeze during childhood. These findings are in keeping with the results of 2 recently published randomized clinical trials of vitamin D supplementation during pregnancy.

Authors+Show Affiliations

Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, Ind.Respiratory, Critical Care and Anaesthesia, UCL Institute of Child Health, London, United Kingdom.School of Clinical Sciences, University of Bristol, Bristol, United Kingdom.Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.Department of Clinical Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, and the Shanghai Institute of Pediatric Research, Shanghai, China; Department of Pediatric Surgery, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: wanyp204@163.com.Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, Ind. Electronic address: kahe@indiana.edu.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

27639938

Citation

Feng, Haixia, et al. "In Utero Exposure to 25-hydroxyvitamin D and Risk of Childhood Asthma, Wheeze, and Respiratory Tract Infections: a Meta-analysis of Birth Cohort Studies." The Journal of Allergy and Clinical Immunology, vol. 139, no. 5, 2017, pp. 1508-1517.
Feng H, Xun P, Pike K, et al. In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies. J Allergy Clin Immunol. 2017;139(5):1508-1517.
Feng, H., Xun, P., Pike, K., Wills, A. K., Chawes, B. L., Bisgaard, H., Cai, W., Wan, Y., & He, K. (2017). In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies. The Journal of Allergy and Clinical Immunology, 139(5), 1508-1517. https://doi.org/10.1016/j.jaci.2016.06.065
Feng H, et al. In Utero Exposure to 25-hydroxyvitamin D and Risk of Childhood Asthma, Wheeze, and Respiratory Tract Infections: a Meta-analysis of Birth Cohort Studies. J Allergy Clin Immunol. 2017;139(5):1508-1517. PubMed PMID: 27639938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies. AU - Feng,Haixia, AU - Xun,Pengcheng, AU - Pike,Katharine, AU - Wills,Andrew K, AU - Chawes,Bo L, AU - Bisgaard,Hans, AU - Cai,Wei, AU - Wan,Yanping, AU - He,Ka, Y1 - 2016/09/14/ PY - 2016/02/09/received PY - 2016/05/19/revised PY - 2016/06/03/accepted PY - 2016/9/19/pubmed PY - 2017/8/19/medline PY - 2016/9/19/entrez KW - 25(OH)D KW - asthma KW - birth cohort studies KW - meta-analysis KW - respiratory tract infections KW - wheeze SP - 1508 EP - 1517 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 139 IS - 5 N2 - BACKGROUND: Studies of the associations between in utero 25-hydroxyvitamin D (25[OH]D) exposure and risk of childhood asthma, wheeze, and respiratory tract infections are inconsistent and inconclusive. OBJECTIVES: We sought to assess associations between 25(OH)D levels in cord blood or maternal venous blood and risk of offspring's asthma, wheeze, and respiratory tract infections. METHODS: Data were derived from PubMed, Embase, Google Scholar, references from relevant articles, and de novo results from published studies until December 2015. A random-effects meta-analysis was conducted among 16 birth cohort studies. RESULTS: Comparing the highest with the lowest category of 25(OH)D levels, the pooled odds ratios were 0.84 (95% CI, 0.70-1.01; P = .064) for asthma, 0.77 (95% CI, 0.58-1.03; P = .083) for wheeze, and 0.85 (95% CI, 0.66-1.09; P = .187) for respiratory tract infections. The observed inverse association for wheeze was more pronounced and became statistically significant in the studies that measured 25(OH)D levels in cord blood (0.43; 95% CI, 0.29-0.62; P < .001). CONCLUSIONS: Accumulated evidence generated from this meta-analysis suggests that increased in utero exposure to 25(OH)D is inversely associated with the risk of asthma and wheeze during childhood. These findings are in keeping with the results of 2 recently published randomized clinical trials of vitamin D supplementation during pregnancy. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/27639938/In_utero_exposure_to_25_hydroxyvitamin_D_and_risk_of_childhood_asthma_wheeze_and_respiratory_tract_infections:_A_meta_analysis_of_birth_cohort_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(16)30962-9 DB - PRIME DP - Unbound Medicine ER -