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Perioperative Quality of Life in Cushing's Disease.
Can J Neurol Sci 2017; 44(1):69-77CJ

Abstract

BACKGROUND

Our study evaluated the perioperative quality of life (QoL) in Cushing's disease (CD) patients, along with correlations between patient variables and cure rate.

METHODS

The 36-item Short-Form Health Survey (SF)-36 questionnaire was used to assess perioperative QoL. Patients completed one survey preoperatively and two surveys postoperatively. Retrospective chart review was conducted to collect SF-36 data as well as examine variables including: age, hospital stay, size of tumour, pathological diagnosis, timing of cure, and complication rates. Statistical analysis was conducted on the scores reported by the SF-36, and were compared with the normal Canadian population values, and to a sample of QoL from nonfunctioning pituitary tumour patients. This project was approved by University of British Columbia Research Ethics Board #H15-01572.

RESULTS

In general, CD patients have relatively poor QoL that does improve as expected when cured, but not quite to normal levels. Factors associated with cure included presence of macroadenoma, confirmatory pathology, and patient age. Postoperative timing of cure appears to affect the durability of cure, with an immediate cure having a higher durability rate than delayed cure. Most recurrences occurred within 10 months postoperatively.

CONCLUSIONS

This review of the perioperative QoL in CD helps to illustrate how QoL changes throughout the treatment process, how QoL compares to normal Canadian population levels, and how QoL compares to patients with nonfunctioning pituitary adenomas. As treatment outcome has such a high impact on QoL, the variables identified in this study will help to better inform patients about the treatment course.

Authors+Show Affiliations

1Faculty of Medicine,University of British Columbia,Vancouver,British Columbia,Canada.1Faculty of Medicine,University of British Columbia,Vancouver,British Columbia,Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27645104

Citation

Ye, Vincent Chen, and Ryojo Akagami. "Perioperative Quality of Life in Cushing's Disease." The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques, vol. 44, no. 1, 2017, pp. 69-77.
Ye VC, Akagami R. Perioperative Quality of Life in Cushing's Disease. Can J Neurol Sci. 2017;44(1):69-77.
Ye, V. C., & Akagami, R. (2017). Perioperative Quality of Life in Cushing's Disease. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques, 44(1), pp. 69-77. doi:10.1017/cjn.2016.295.
Ye VC, Akagami R. Perioperative Quality of Life in Cushing's Disease. Can J Neurol Sci. 2017;44(1):69-77. PubMed PMID: 27645104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perioperative Quality of Life in Cushing's Disease. AU - Ye,Vincent Chen, AU - Akagami,Ryojo, Y1 - 2016/09/20/ PY - 2016/9/21/pubmed PY - 2017/2/18/medline PY - 2016/9/21/entrez KW - Neurosurgery KW - Pituitary Adenomas KW - Quality of Life SP - 69 EP - 77 JF - The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques JO - Can J Neurol Sci VL - 44 IS - 1 N2 - BACKGROUND: Our study evaluated the perioperative quality of life (QoL) in Cushing's disease (CD) patients, along with correlations between patient variables and cure rate. METHODS: The 36-item Short-Form Health Survey (SF)-36 questionnaire was used to assess perioperative QoL. Patients completed one survey preoperatively and two surveys postoperatively. Retrospective chart review was conducted to collect SF-36 data as well as examine variables including: age, hospital stay, size of tumour, pathological diagnosis, timing of cure, and complication rates. Statistical analysis was conducted on the scores reported by the SF-36, and were compared with the normal Canadian population values, and to a sample of QoL from nonfunctioning pituitary tumour patients. This project was approved by University of British Columbia Research Ethics Board #H15-01572. RESULTS: In general, CD patients have relatively poor QoL that does improve as expected when cured, but not quite to normal levels. Factors associated with cure included presence of macroadenoma, confirmatory pathology, and patient age. Postoperative timing of cure appears to affect the durability of cure, with an immediate cure having a higher durability rate than delayed cure. Most recurrences occurred within 10 months postoperatively. CONCLUSIONS: This review of the perioperative QoL in CD helps to illustrate how QoL changes throughout the treatment process, how QoL compares to normal Canadian population levels, and how QoL compares to patients with nonfunctioning pituitary adenomas. As treatment outcome has such a high impact on QoL, the variables identified in this study will help to better inform patients about the treatment course. SN - 0317-1671 UR - https://www.unboundmedicine.com/medline/citation/27645104/Perioperative_Quality_of_Life_in_Cushing's_Disease_ L2 - https://www.cambridge.org/core/product/identifier/S031716711600295X/type/journal_article DB - PRIME DP - Unbound Medicine ER -