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Statin intolerance - a question of definition.
Expert Opin Drug Saf. 2017 Jan; 16(1):55-63.EO

Abstract

INTRODUCTION

Statin therapy is the backbone of pharmacologic therapy for low-density lipoproteins cholesterol lowering and plays a pivotal role in cardiovascular disease prevention. Statin intolerance is understood as the inability to continue using a statin to reduce individual cardiovascular risk sufficiently, due to the development of symptoms or laboratory abnormalities attributable to the initiation or dose escalation of a statin. Muscle symptoms are the most common side effects observed. Areas covered: The main aim of this article is to present a review on published definitions of statin intolerance. In addition, a brief review on clinical aspects and risk factors of statin intolerance is provided and features for a common definition for statin intolerance are suggested. Expert opinion: A definition of statin intolerance by major drug regulatory agencies is not available. In clinical studies, different definitions are chosen and results are not comparable; different medical associations do not agree on one common definition. There is an unmet need to establish a common definition of statin intolerance to ensure an appropriate clinical use of this important drug class. Further work is required to develop a consensus definition on statin intolerance that could have significant positive impact on both research and clinical management.

Authors+Show Affiliations

a Institut für Klinische Pharmakologie und Toxikologie , Charité - Universitätsmedizin Berlin , Berlin , Germany. b Department of Clinical Pharmacy, Faculty of Pharmacy , Ain Shams University , Cairo , Egypt.a Institut für Klinische Pharmakologie und Toxikologie , Charité - Universitätsmedizin Berlin , Berlin , Germany.c Sanofi-Aventis Deutschland GmbH , Evidence Based Medicine , Berlin , Germany.a Institut für Klinische Pharmakologie und Toxikologie , Charité - Universitätsmedizin Berlin , Berlin , Germany.a Institut für Klinische Pharmakologie und Toxikologie , Charité - Universitätsmedizin Berlin , Berlin , Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27645111

Citation

Algharably, Engi Abdel-Hady, et al. "Statin Intolerance - a Question of Definition." Expert Opinion On Drug Safety, vol. 16, no. 1, 2017, pp. 55-63.
Algharably EA, Filler I, Rosenfeld S, et al. Statin intolerance - a question of definition. Expert Opin Drug Saf. 2017;16(1):55-63.
Algharably, E. A., Filler, I., Rosenfeld, S., Grabowski, K., & Kreutz, R. (2017). Statin intolerance - a question of definition. Expert Opinion On Drug Safety, 16(1), 55-63.
Algharably EA, et al. Statin Intolerance - a Question of Definition. Expert Opin Drug Saf. 2017;16(1):55-63. PubMed PMID: 27645111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statin intolerance - a question of definition. AU - Algharably,Engi Abdel-Hady, AU - Filler,Iris, AU - Rosenfeld,Stephanie, AU - Grabowski,Katja, AU - Kreutz,Reinhold, Y1 - 2016/09/27/ PY - 2016/9/21/pubmed PY - 2017/3/11/medline PY - 2016/9/21/entrez KW - HMG-CoA reductase inhibitors KW - PCSK9 inhibitors KW - hypercholesterolemia KW - myopathy KW - statin adverse effects KW - statin discontinuation SP - 55 EP - 63 JF - Expert opinion on drug safety JO - Expert Opin Drug Saf VL - 16 IS - 1 N2 - INTRODUCTION: Statin therapy is the backbone of pharmacologic therapy for low-density lipoproteins cholesterol lowering and plays a pivotal role in cardiovascular disease prevention. Statin intolerance is understood as the inability to continue using a statin to reduce individual cardiovascular risk sufficiently, due to the development of symptoms or laboratory abnormalities attributable to the initiation or dose escalation of a statin. Muscle symptoms are the most common side effects observed. Areas covered: The main aim of this article is to present a review on published definitions of statin intolerance. In addition, a brief review on clinical aspects and risk factors of statin intolerance is provided and features for a common definition for statin intolerance are suggested. Expert opinion: A definition of statin intolerance by major drug regulatory agencies is not available. In clinical studies, different definitions are chosen and results are not comparable; different medical associations do not agree on one common definition. There is an unmet need to establish a common definition of statin intolerance to ensure an appropriate clinical use of this important drug class. Further work is required to develop a consensus definition on statin intolerance that could have significant positive impact on both research and clinical management. SN - 1744-764X UR - https://www.unboundmedicine.com/medline/citation/27645111/Statin_intolerance___a_question_of_definition_ L2 - http://www.tandfonline.com/doi/full/10.1080/14740338.2017.1238898 DB - PRIME DP - Unbound Medicine ER -