Tags

Type your tag names separated by a space and hit enter

Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography.
J Chromatogr A. 2016 Oct 14; 1468:79-85.JC

Abstract

In this paper, a novel 2-methylimidazolium-functionalized silica stationary phase was prepared and further used for hydrophilic interaction and anion-exchange mixed-mode chromatography. The stationary phase was characterized by elemental analysis and Fourier transform infrared spectrometry. The chromatographic properties of this stationary phase were investigated by hydrophilic chromatography for the separation of nucleosides, nucleobases, water soluble vitamins, sulfonamides and saccharides, and ion chromatography for the separation of inorganic anions. The effect of acetonitrile content, salt concentration and pH values of the mobile phase on the retention of the stationary phases was also investigated. Compared with 1-methylimidazolium-functionalized silica stationary phase, this new stationary phase demonstrated similar or better separation selectivity. This new column demonstrated good performance and separation selectivity even better than a commercial hydrophilic column. Besides, 2-methylimidazolium-functionalized silica is possible to be modified again and used as a precursor to derivate some new stationary phases from the 3-position nitrogen.

Authors+Show Affiliations

Laboratory on Pollution Monitoring and Control, College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, China; Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.Laboratory on Pollution Monitoring and Control, College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, China. Electronic address: guanm@xjnu.edu.cn.Laboratory on Pollution Monitoring and Control, College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, China; Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China. Electronic address: hdqiu@licp.cas.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27646061

Citation

Yang, Beibei, et al. "Preparation and Evaluation of 2-methylimidazolium-functionalized Silica as a Mixed-mode Stationary Phase for Hydrophilic Interaction and Anion-exchange Chromatography." Journal of Chromatography. A, vol. 1468, 2016, pp. 79-85.
Yang B, Liu H, Chen J, et al. Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography. J Chromatogr A. 2016;1468:79-85.
Yang, B., Liu, H., Chen, J., Guan, M., & Qiu, H. (2016). Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography. Journal of Chromatography. A, 1468, 79-85. https://doi.org/10.1016/j.chroma.2016.09.021
Yang B, et al. Preparation and Evaluation of 2-methylimidazolium-functionalized Silica as a Mixed-mode Stationary Phase for Hydrophilic Interaction and Anion-exchange Chromatography. J Chromatogr A. 2016 Oct 14;1468:79-85. PubMed PMID: 27646061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography. AU - Yang,Beibei, AU - Liu,Houmei, AU - Chen,Jia, AU - Guan,Ming, AU - Qiu,Hongdeng, Y1 - 2016/09/14/ PY - 2016/07/15/received PY - 2016/09/02/revised PY - 2016/09/11/accepted PY - 2016/9/21/pubmed PY - 2017/3/9/medline PY - 2016/9/21/entrez KW - 2-Methylimidazolium-functionalized silica KW - Hydrophilic interaction liquid chromatography KW - Ion exchange chromatography KW - Mixed-mode separation KW - Stationary phase SP - 79 EP - 85 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1468 N2 - In this paper, a novel 2-methylimidazolium-functionalized silica stationary phase was prepared and further used for hydrophilic interaction and anion-exchange mixed-mode chromatography. The stationary phase was characterized by elemental analysis and Fourier transform infrared spectrometry. The chromatographic properties of this stationary phase were investigated by hydrophilic chromatography for the separation of nucleosides, nucleobases, water soluble vitamins, sulfonamides and saccharides, and ion chromatography for the separation of inorganic anions. The effect of acetonitrile content, salt concentration and pH values of the mobile phase on the retention of the stationary phases was also investigated. Compared with 1-methylimidazolium-functionalized silica stationary phase, this new stationary phase demonstrated similar or better separation selectivity. This new column demonstrated good performance and separation selectivity even better than a commercial hydrophilic column. Besides, 2-methylimidazolium-functionalized silica is possible to be modified again and used as a precursor to derivate some new stationary phases from the 3-position nitrogen. SN - 1873-3778 UR - https://www.unboundmedicine.com/medline/citation/27646061/Preparation_and_evaluation_of_2_methylimidazolium_functionalized_silica_as_a_mixed_mode_stationary_phase_for_hydrophilic_interaction_and_anion_exchange_chromatography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(16)31207-9 DB - PRIME DP - Unbound Medicine ER -