Tags

Type your tag names separated by a space and hit enter

Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves.
Pharm Biol. 2017 Dec; 55(1):33-42.PB

Abstract

CONTEXT

Boswellia dalzielii Hutch. (Burseraceae) is an aromatic plant. The leaves are used for beverage flavouring.

OBJECTIVE

This study investigates the chemical composition and biological activities of various extracts.

MATERIALS AND METHODS

The essential oil was prepared via hydrodistillation. Identification and quantification were realized via GC-MS and GC-FID. Consecutive extractions (cyclohexane, dichloromethane, ethyl acetate and methanol) were carried out and various chemical groups (phenolics, flavonoids, tannins, antocyanins and sugar) were quantified. The volatile compounds of organic extracts were identified before and after derivatization. Antioxidant, antihyperuricemia, anti-Alzheimer, anti-inflammatory and anticancer activities were evaluated.

RESULTS

In the essential oil, 50 compounds were identified, including 3-carene (27.72%) and α-pinene (15.18%). 2,5-Dihydroxy acetophenone and β-d-xylopyranose were identified in the methanol extract. Higher phenolic (315.97 g GAE/kg dry mass) and flavonoid (37.19 g QE/kg dry mass) contents were observed in the methanol extract. The methanol extract has presented remarkable IC50 = 6.10 mg/L for antiDPPH, 35.10 mg/L for antixanthine oxidase and 28.01 mg/L for anti-5-lipoxygenase. For acetylcholinesterase inhibition, the best IC50 (76.20 and 67.10 mg/L) were observed, respectively, with an ethyl acetate extract and the essential oil. At 50 mg/L, the dichloromethane extract inhibited OVCAR-3 cell lines by 65.10%, while cyclohexane extract inhibited IGROV-1 cell lines by 92.60%.

DISCUSSION AND CONCLUSION

Biological activities were fully correlated with the chemical groups of the extracts. The ethyl acetate and methanol extracts could be considered as potential alternatives for use in dietary supplements for the prevention or treatment of diseases because of these extracts natural antioxidant, antihyperuricemic and anti-inflammatory activities.

Authors+Show Affiliations

a Laboratoire des IMRCP UMR CNRS 5623, Faculté de pharmacie de Toulouse, Université de Toulouse , Toulouse , France. b Laboratoire de Pharmacognosie, Center Béninois de la Recherche Scientifique et Technique (CBRST), Université Paul-Sabatier , Porto-Novo , Benin. c Laboratory of Physical Organic Chemistry and Synthesis (LaCOPS), Faculty of Technical Sciences, University of Abomey Calavi , Contonou , Benin.b Laboratoire de Pharmacognosie, Center Béninois de la Recherche Scientifique et Technique (CBRST), Université Paul-Sabatier , Porto-Novo , Benin. c Laboratory of Physical Organic Chemistry and Synthesis (LaCOPS), Faculty of Technical Sciences, University of Abomey Calavi , Contonou , Benin.b Laboratoire de Pharmacognosie, Center Béninois de la Recherche Scientifique et Technique (CBRST), Université Paul-Sabatier , Porto-Novo , Benin. c Laboratory of Physical Organic Chemistry and Synthesis (LaCOPS), Faculty of Technical Sciences, University of Abomey Calavi , Contonou , Benin.b Laboratoire de Pharmacognosie, Center Béninois de la Recherche Scientifique et Technique (CBRST), Université Paul-Sabatier , Porto-Novo , Benin.a Laboratoire des IMRCP UMR CNRS 5623, Faculté de pharmacie de Toulouse, Université de Toulouse , Toulouse , France.a Laboratoire des IMRCP UMR CNRS 5623, Faculté de pharmacie de Toulouse, Université de Toulouse , Toulouse , France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27650786

Citation

Kohoude, Midéko Justin, et al. "Chemical Composition and Biological Activities of Extracts and Essential Oil of Boswellia Dalzielii Leaves." Pharmaceutical Biology, vol. 55, no. 1, 2017, pp. 33-42.
Kohoude MJ, Gbaguidi F, Agbani P, et al. Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves. Pharm Biol. 2017;55(1):33-42.
Kohoude, M. J., Gbaguidi, F., Agbani, P., Ayedoun, M. A., Cazaux, S., & Bouajila, J. (2017). Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves. Pharmaceutical Biology, 55(1), 33-42.
Kohoude MJ, et al. Chemical Composition and Biological Activities of Extracts and Essential Oil of Boswellia Dalzielii Leaves. Pharm Biol. 2017;55(1):33-42. PubMed PMID: 27650786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves. AU - Kohoude,Midéko Justin, AU - Gbaguidi,Fernand, AU - Agbani,Pierre, AU - Ayedoun,Marc-Abel, AU - Cazaux,Sylvie, AU - Bouajila,Jalloul, Y1 - 2016/09/21/ PY - 2016/9/22/pubmed PY - 2017/3/10/medline PY - 2016/9/22/entrez KW - GC-MS KW - anti-Alzheimer KW - anti-inflammatory KW - anticancer KW - antioxidant KW - derivatization SP - 33 EP - 42 JF - Pharmaceutical biology JO - Pharm Biol VL - 55 IS - 1 N2 - CONTEXT: Boswellia dalzielii Hutch. (Burseraceae) is an aromatic plant. The leaves are used for beverage flavouring. OBJECTIVE: This study investigates the chemical composition and biological activities of various extracts. MATERIALS AND METHODS: The essential oil was prepared via hydrodistillation. Identification and quantification were realized via GC-MS and GC-FID. Consecutive extractions (cyclohexane, dichloromethane, ethyl acetate and methanol) were carried out and various chemical groups (phenolics, flavonoids, tannins, antocyanins and sugar) were quantified. The volatile compounds of organic extracts were identified before and after derivatization. Antioxidant, antihyperuricemia, anti-Alzheimer, anti-inflammatory and anticancer activities were evaluated. RESULTS: In the essential oil, 50 compounds were identified, including 3-carene (27.72%) and α-pinene (15.18%). 2,5-Dihydroxy acetophenone and β-d-xylopyranose were identified in the methanol extract. Higher phenolic (315.97 g GAE/kg dry mass) and flavonoid (37.19 g QE/kg dry mass) contents were observed in the methanol extract. The methanol extract has presented remarkable IC50 = 6.10 mg/L for antiDPPH, 35.10 mg/L for antixanthine oxidase and 28.01 mg/L for anti-5-lipoxygenase. For acetylcholinesterase inhibition, the best IC50 (76.20 and 67.10 mg/L) were observed, respectively, with an ethyl acetate extract and the essential oil. At 50 mg/L, the dichloromethane extract inhibited OVCAR-3 cell lines by 65.10%, while cyclohexane extract inhibited IGROV-1 cell lines by 92.60%. DISCUSSION AND CONCLUSION: Biological activities were fully correlated with the chemical groups of the extracts. The ethyl acetate and methanol extracts could be considered as potential alternatives for use in dietary supplements for the prevention or treatment of diseases because of these extracts natural antioxidant, antihyperuricemic and anti-inflammatory activities. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/27650786/Chemical_composition_and_biological_activities_of_extracts_and_essential_oil_of_Boswellia_dalzielii_leaves_ L2 - https://www.tandfonline.com/doi/full/10.1080/13880209.2016.1226356 DB - PRIME DP - Unbound Medicine ER -