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Do statins really cause diabetes? A meta-analysis of major randomized controlled clinical trials.

Abstract

OBJECTIVES

To investigate and establish the relationship between the use of statin therapy and the risk of development of diabetes.

METHODS

PubMed and the Cochrane Central Register of Controlled Trials was searched for randomized controlled end-point trials of statins, with more than 1000 subjects and a minimum of one-year follow-up period, published until August 2015. The odds ratio (OR) of diabetes incidence with overall statin therapy as well as with different statins in question was calculated through random effect meta-analysis model.

RESULTS

Fourteen studies were included in the analysis with a total of 94,943 participants. Of these, 2392 subjects developed incident diabetes in the statin and 2167 in the placebo groups during a 4-year follow-up. The OR of diabetes incidence with statin therapy was significantly higher as compared with the placebo group (OR=1.11; 95% confidence interval = 1.0 to 1.2; p=0.007). There was an insignificant level of heterogeneity between the included trials (Cochran Q= 19.463, p=0.109, I2=33.20). Subgroup analysis showed that only 2 statins namely, atorvastatin (OR= 1.29; p=0.042) and rosuvastatin (OR = 1.17; p=0.01) were significantly associated.

CONCLUSION

Statin therapy can slightly increase risk of incident diabetes in subjects with hypercholesterolemia.

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  • Authors+Show Affiliations

    ,

    Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon. E-mail. alolita_rahal_470@hotmail.com.

    , ,

    Source

    Saudi medical journal 37:10 2016 Oct pg 1051-60

    MeSH

    Diabetes Mellitus
    Humans
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Randomized Controlled Trials as Topic

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    27652354

    Citation

    Rahal, Alaa J., et al. "Do Statins Really Cause Diabetes? a Meta-analysis of Major Randomized Controlled Clinical Trials." Saudi Medical Journal, vol. 37, no. 10, 2016, pp. 1051-60.
    Rahal AJ, ElMallah AI, Poushuju RJ, et al. Do statins really cause diabetes? A meta-analysis of major randomized controlled clinical trials. Saudi Med J. 2016;37(10):1051-60.
    Rahal, A. J., ElMallah, A. I., Poushuju, R. J., & Itani, R. (2016). Do statins really cause diabetes? A meta-analysis of major randomized controlled clinical trials. Saudi Medical Journal, 37(10), pp. 1051-60. doi:10.15537/smj.2016.10.16078.
    Rahal AJ, et al. Do Statins Really Cause Diabetes? a Meta-analysis of Major Randomized Controlled Clinical Trials. Saudi Med J. 2016;37(10):1051-60. PubMed PMID: 27652354.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Do statins really cause diabetes? A meta-analysis of major randomized controlled clinical trials. AU - Rahal,Alaa J, AU - ElMallah,Ahmed I, AU - Poushuju,Rita J, AU - Itani,Rana, PY - 2016/9/22/entrez PY - 2016/9/22/pubmed PY - 2017/5/24/medline SP - 1051 EP - 60 JF - Saudi medical journal JO - Saudi Med J VL - 37 IS - 10 N2 - OBJECTIVES: To investigate and establish the relationship between the use of statin therapy and the risk of development of diabetes. METHODS: PubMed and the Cochrane Central Register of Controlled Trials was searched for randomized controlled end-point trials of statins, with more than 1000 subjects and a minimum of one-year follow-up period, published until August 2015. The odds ratio (OR) of diabetes incidence with overall statin therapy as well as with different statins in question was calculated through random effect meta-analysis model. RESULTS: Fourteen studies were included in the analysis with a total of 94,943 participants. Of these, 2392 subjects developed incident diabetes in the statin and 2167 in the placebo groups during a 4-year follow-up. The OR of diabetes incidence with statin therapy was significantly higher as compared with the placebo group (OR=1.11; 95% confidence interval = 1.0 to 1.2; p=0.007). There was an insignificant level of heterogeneity between the included trials (Cochran Q= 19.463, p=0.109, I2=33.20). Subgroup analysis showed that only 2 statins namely, atorvastatin (OR= 1.29; p=0.042) and rosuvastatin (OR = 1.17; p=0.01) were significantly associated. CONCLUSION: Statin therapy can slightly increase risk of incident diabetes in subjects with hypercholesterolemia. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/27652354/Do_statins_really_cause_diabetes_A_meta_analysis_of_major_randomized_controlled_clinical_trials_ L2 - https://doi.org/10.15537/smj.2016.10.16078 DB - PRIME DP - Unbound Medicine ER -