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Conversion of xanthine dehydrogenase to xanthine oxidase as a possible marker for hypoxia in tumours and normal tissues.
Br J Cancer. 1989 Aug; 60(2):193-7.BJ

Abstract

The enzyme activities of endogenous xanthine dehydrogenase (XDH) and xanthine oxidase (XO) have been measured in 10 different types of mouse tumour and seven normal tissues. The conversion of XDH to XO has been observed in two tumour types upon the prolonged clamping off of the blood supply to the tumours. It is proposed that a similar conversion might also occur naturally in chronically hypoxic cells and that the ratio of the XO activity to the combined XO + XDH activities (%XO activity) could well serve as a marker for tissue hypoxia. A qualitative relationship exists between the %XO activity and literature values of the hypoxic fraction for some tumours measured by radiobiological assays. The influence of tumour size (about 0.2-1.8 g) on %XO activity is presented for all 10 tumours as well as %XO activity determinations for four of the normal tissues.

Authors+Show Affiliations

Cancer Research Campaign Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2765364

Citation

Anderson, R F., et al. "Conversion of Xanthine Dehydrogenase to Xanthine Oxidase as a Possible Marker for Hypoxia in Tumours and Normal Tissues." British Journal of Cancer, vol. 60, no. 2, 1989, pp. 193-7.
Anderson RF, Patel KB, Reghebi K, et al. Conversion of xanthine dehydrogenase to xanthine oxidase as a possible marker for hypoxia in tumours and normal tissues. Br J Cancer. 1989;60(2):193-7.
Anderson, R. F., Patel, K. B., Reghebi, K., & Hill, S. A. (1989). Conversion of xanthine dehydrogenase to xanthine oxidase as a possible marker for hypoxia in tumours and normal tissues. British Journal of Cancer, 60(2), 193-7.
Anderson RF, et al. Conversion of Xanthine Dehydrogenase to Xanthine Oxidase as a Possible Marker for Hypoxia in Tumours and Normal Tissues. Br J Cancer. 1989;60(2):193-7. PubMed PMID: 2765364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conversion of xanthine dehydrogenase to xanthine oxidase as a possible marker for hypoxia in tumours and normal tissues. AU - Anderson,R F, AU - Patel,K B, AU - Reghebi,K, AU - Hill,S A, PY - 1989/8/1/pubmed PY - 1989/8/1/medline PY - 1989/8/1/entrez SP - 193 EP - 7 JF - British journal of cancer JO - Br J Cancer VL - 60 IS - 2 N2 - The enzyme activities of endogenous xanthine dehydrogenase (XDH) and xanthine oxidase (XO) have been measured in 10 different types of mouse tumour and seven normal tissues. The conversion of XDH to XO has been observed in two tumour types upon the prolonged clamping off of the blood supply to the tumours. It is proposed that a similar conversion might also occur naturally in chronically hypoxic cells and that the ratio of the XO activity to the combined XO + XDH activities (%XO activity) could well serve as a marker for tissue hypoxia. A qualitative relationship exists between the %XO activity and literature values of the hypoxic fraction for some tumours measured by radiobiological assays. The influence of tumour size (about 0.2-1.8 g) on %XO activity is presented for all 10 tumours as well as %XO activity determinations for four of the normal tissues. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/2765364/Conversion_of_xanthine_dehydrogenase_to_xanthine_oxidase_as_a_possible_marker_for_hypoxia_in_tumours_and_normal_tissues_ L2 - https://doi.org/10.1038/bjc.1989.249 DB - PRIME DP - Unbound Medicine ER -