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Burkholderia pseudomallei: Challenges for the Clinical Microbiology Laboratory.
J Clin Microbiol. 2016 12; 54(12):2866-2873.JC

Abstract

Melioidosis is a potentially fatal infection caused by the bacterium Burkholderia pseudomallei Clinical diagnosis of melioidosis can be challenging since there is no pathognomonic clinical syndrome, and the organism is often misidentified by methods used routinely in clinical laboratories. Although the disease is more prevalent in Thailand and northern Australia, sporadic cases may be encountered in areas where it is not endemic, including the United States. Since the organism is considered a tier 1 select agent according to the Centers for Disease Control and Prevention and the U.S. Department of Agriculture Animal and Plant Health Inspection Service, clinical laboratories must be proficient at rapidly recognizing isolates suspicious for B. pseudomallei, be able to safely perform necessary rule-out tests, and to refer suspect isolates to Laboratory Response Network reference laboratories. In this minireview, we report a case of melioidosis encountered at our institution and discuss the laboratory challenges encountered when dealing with clinical isolates suspicious for B. pseudomallei or clinical specimens from suspected melioidosis cases.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA rhumphries@mednet.ucla.edu.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

27654336

Citation

Hemarajata, Peera, et al. "Burkholderia Pseudomallei: Challenges for the Clinical Microbiology Laboratory." Journal of Clinical Microbiology, vol. 54, no. 12, 2016, pp. 2866-2873.
Hemarajata P, Baghdadi JD, Hoffman R, et al. Burkholderia pseudomallei: Challenges for the Clinical Microbiology Laboratory. J Clin Microbiol. 2016;54(12):2866-2873.
Hemarajata, P., Baghdadi, J. D., Hoffman, R., & Humphries, R. M. (2016). Burkholderia pseudomallei: Challenges for the Clinical Microbiology Laboratory. Journal of Clinical Microbiology, 54(12), 2866-2873.
Hemarajata P, et al. Burkholderia Pseudomallei: Challenges for the Clinical Microbiology Laboratory. J Clin Microbiol. 2016;54(12):2866-2873. PubMed PMID: 27654336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Burkholderia pseudomallei: Challenges for the Clinical Microbiology Laboratory. AU - Hemarajata,Peera, AU - Baghdadi,Jonathan D, AU - Hoffman,Risa, AU - Humphries,Romney M, Y1 - 2016/09/21/ PY - 2016/9/23/pubmed PY - 2017/8/5/medline PY - 2016/9/23/entrez SP - 2866 EP - 2873 JF - Journal of clinical microbiology JO - J Clin Microbiol VL - 54 IS - 12 N2 - Melioidosis is a potentially fatal infection caused by the bacterium Burkholderia pseudomallei Clinical diagnosis of melioidosis can be challenging since there is no pathognomonic clinical syndrome, and the organism is often misidentified by methods used routinely in clinical laboratories. Although the disease is more prevalent in Thailand and northern Australia, sporadic cases may be encountered in areas where it is not endemic, including the United States. Since the organism is considered a tier 1 select agent according to the Centers for Disease Control and Prevention and the U.S. Department of Agriculture Animal and Plant Health Inspection Service, clinical laboratories must be proficient at rapidly recognizing isolates suspicious for B. pseudomallei, be able to safely perform necessary rule-out tests, and to refer suspect isolates to Laboratory Response Network reference laboratories. In this minireview, we report a case of melioidosis encountered at our institution and discuss the laboratory challenges encountered when dealing with clinical isolates suspicious for B. pseudomallei or clinical specimens from suspected melioidosis cases. SN - 1098-660X UR - https://www.unboundmedicine.com/medline/citation/27654336/Burkholderia_pseudomallei:_Challenges_for_the_Clinical_Microbiology_Laboratory_ L2 - http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=27654336 DB - PRIME DP - Unbound Medicine ER -