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Association of vitamin D deficiency with hepatitis B virus - related liver diseases.
BMC Infect Dis. 2016 Sep 23; 16(1):507.BI

Abstract

BACKGROUND

As an immune modulator, vitamin D is involved in various pathophysiological mechanisms in a plethora of diseases. This study aims to correlate the vitamin D deficiency status and clinical progression of liver diseases associated with hepatitis B virus (HBV) infection in patients in Vietnam and to compare it to healthy controls.

METHODS

We quantified the levels of total vitamin D [25-(OH) D2 and D3] in serum samples from 400 HBV patients (chronic hepatitis B infection [CHB], n = 165; HBV-associated liver cirrhosis [LC], n = 127; HBV-associated hepatocellular carcinoma [HCC], n = 108) and 122 unrelated healthy controls (HC). Univariate and multivariate analyses were performed in order to determine the association between vitamin D levels and distinct clinical parameters.

RESULTS

The prevalence of vitamin D inadequacy (<30 ng/mL) was high among healthy individuals (81.7 %) as well as in HBV patients (84.3 %). Vitamin D deficiency (<20 ng/ml) or severe deficiency (<10 ng/ml) was observed more frequently among HBV patients (52 %) and subgroups (CHB, 47.8 %; LC, 54.4 %; HCC, 55.3 %) compared to the control group (32.5 %) (P < 0.001). Vitamin D levels and HBV-DNA load were strongly and inversely correlated (rho = -0.57, P < 0.0001). Multivariate regression analysis also revealed an independent association of HBV-DNA loads with low vitamin D levels (P = 0.0004). In addition, reduced vitamin D levels were associated with significant clinical progression of LC (Child-Pugh C versus Child-Pugh A, P = 0.0018; Child-Pugh C versus Child-Pugh B, P = 0.016).

CONCLUSIONS

Vitamin D deficiency was observed in the majority of HBV-infected patients and associated with adverse clinical outcomes. Our findings suggest that substitution of vitamin D may be a supportive option in the treatment of chronic liver diseases, in particular of HBV-associated disorders.

Authors+Show Affiliations

Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam.Department of Infectious Diseases, Duc Giang Hospital, Hanoi, Vietnam.Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam.Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam.Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam.Department of Molecular Biology, 108 Military Central Hospital, Hanoi, Vietnam.Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam. Department of Molecular Biology, 108 Military Central Hospital, Hanoi, Vietnam.Department of Infectious Diseases, Vietnam Military Medical University, Hanoi, Vietnam.Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam. Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam.Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam.Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam.Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam. Fondation Congolaise pour la Recherche Medicale, Brazzaville, Republic of Congo.Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam. lehuusong@108-icid.com. Institute of Clinical Infectious Diseases, 108 Military Central Hospital, Tran Hung Dao Street N1, Hai Ba Trung District, Hanoi, Vietnam. lehuusong@108-icid.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27659316

Citation

Hoan, Nghiem Xuan, et al. "Association of Vitamin D Deficiency With Hepatitis B Virus - Related Liver Diseases." BMC Infectious Diseases, vol. 16, no. 1, 2016, p. 507.
Hoan NX, Khuyen N, Binh MT, et al. Association of vitamin D deficiency with hepatitis B virus - related liver diseases. BMC Infect Dis. 2016;16(1):507.
Hoan, N. X., Khuyen, N., Binh, M. T., Giang, D. P., Van Tong, H., Hoan, P. Q., Trung, N. T., Anh, D. T., Toan, N. L., Meyer, C. G., Kremsner, P. G., Velavan, T. P., & Song, L. H. (2016). Association of vitamin D deficiency with hepatitis B virus - related liver diseases. BMC Infectious Diseases, 16(1), 507.
Hoan NX, et al. Association of Vitamin D Deficiency With Hepatitis B Virus - Related Liver Diseases. BMC Infect Dis. 2016 Sep 23;16(1):507. PubMed PMID: 27659316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of vitamin D deficiency with hepatitis B virus - related liver diseases. AU - Hoan,Nghiem Xuan, AU - Khuyen,Nguyen, AU - Binh,Mai Thanh, AU - Giang,Dao Phuong, AU - Van Tong,Hoang, AU - Hoan,Phan Quoc, AU - Trung,Ngo Tat, AU - Anh,Do Tuan, AU - Toan,Nguyen Linh, AU - Meyer,Christian G, AU - Kremsner,Peter G, AU - Velavan,Thirumalaisamy P, AU - Song,Le Huu, Y1 - 2016/09/23/ PY - 2016/04/02/received PY - 2016/09/16/accepted PY - 2016/9/24/entrez PY - 2016/9/24/pubmed PY - 2016/9/24/medline KW - Chronic liver disease KW - HBV infection KW - Hepatocellular carcinoma KW - Liver cirrhosis KW - Vitamin D deficiency SP - 507 EP - 507 JF - BMC infectious diseases JO - BMC Infect. Dis. VL - 16 IS - 1 N2 - BACKGROUND: As an immune modulator, vitamin D is involved in various pathophysiological mechanisms in a plethora of diseases. This study aims to correlate the vitamin D deficiency status and clinical progression of liver diseases associated with hepatitis B virus (HBV) infection in patients in Vietnam and to compare it to healthy controls. METHODS: We quantified the levels of total vitamin D [25-(OH) D2 and D3] in serum samples from 400 HBV patients (chronic hepatitis B infection [CHB], n = 165; HBV-associated liver cirrhosis [LC], n = 127; HBV-associated hepatocellular carcinoma [HCC], n = 108) and 122 unrelated healthy controls (HC). Univariate and multivariate analyses were performed in order to determine the association between vitamin D levels and distinct clinical parameters. RESULTS: The prevalence of vitamin D inadequacy (<30 ng/mL) was high among healthy individuals (81.7 %) as well as in HBV patients (84.3 %). Vitamin D deficiency (<20 ng/ml) or severe deficiency (<10 ng/ml) was observed more frequently among HBV patients (52 %) and subgroups (CHB, 47.8 %; LC, 54.4 %; HCC, 55.3 %) compared to the control group (32.5 %) (P < 0.001). Vitamin D levels and HBV-DNA load were strongly and inversely correlated (rho = -0.57, P < 0.0001). Multivariate regression analysis also revealed an independent association of HBV-DNA loads with low vitamin D levels (P = 0.0004). In addition, reduced vitamin D levels were associated with significant clinical progression of LC (Child-Pugh C versus Child-Pugh A, P = 0.0018; Child-Pugh C versus Child-Pugh B, P = 0.016). CONCLUSIONS: Vitamin D deficiency was observed in the majority of HBV-infected patients and associated with adverse clinical outcomes. Our findings suggest that substitution of vitamin D may be a supportive option in the treatment of chronic liver diseases, in particular of HBV-associated disorders. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/27659316/Association_of_vitamin_D_deficiency_with_hepatitis_B_virus___related_liver_diseases_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1836-0 DB - PRIME DP - Unbound Medicine ER -
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