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The relationship between transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children : Part I: repeatability, observer variability and general analysis.
Childs Nerv Syst. 2016 Oct; 32(10):1769-78.CN

Abstract

PURPOSE

The aim of this study was to investigate the relationship between optic nerve sheath diameter (ONSD) measurement and invasively measured intracranial pressure (ICP) in children.

METHODS

ONSD measurement was performed prior to invasive measurement of ICP. The mean binocular ONSD measurement was compared to the ICP reading. Physiological variables including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse rate, temperature, respiratory rate and end tidal carbon dioxide (ETCO2) level were recorded at the time of ONSD measurement. Diagnostic accuracy analysis was performed at various ICP thresholds and repeatability, intra- and inter-observer variability, correlation between measurements in different imaging planes as well the relationship over the entire patient cohort were examined in part I of this study.

RESULTS

Data from 174 patients were analysed. Repeatability and intra-observer variability were excellent (α = 0.97-0.99). Testing for inter-observer variability revealed good correlation (r = 0.89, p < 0.001). Imaging in the sagittal plane demonstrated a slightly better correlation with ICP (r = 0.66, p < 0.001). The ONSD measurement with the best diagnostic accuracy for detecting an ICP ≥ 20 mmHg over the entire patient cohort was 5.5 mm, sensitivity 93.2 %, specificity 74 % and odds ratio (OR) of 39.3.

CONCLUSION

Transorbital ultrasound measurement of the OSND is a reliable and reproducible technique, demonstrating a good relationship with ICP and high diagnostic accuracy for detecting raised ICP.

Authors+Show Affiliations

Paediatric Neurosurgery Unit, Division of Neurosurgery, Faculty of Health Sciences, University of Cape Town, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. llewesp@yahoo.com.Trauma Unit, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa.Department of Paediatric Aneasthesia, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.Paediatric Neurosurgery Unit, Division of Neurosurgery, Faculty of Health Sciences, University of Cape Town, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27659819

Citation

Padayachy, Llewellyn C., et al. "The Relationship Between Transorbital Ultrasound Measurement of the Optic Nerve Sheath Diameter (ONSD) and Invasively Measured ICP in Children : Part I: Repeatability, Observer Variability and General Analysis." Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery, vol. 32, no. 10, 2016, pp. 1769-78.
Padayachy LC, Padayachy V, Galal U, et al. The relationship between transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children : Part I: repeatability, observer variability and general analysis. Childs Nerv Syst. 2016;32(10):1769-78.
Padayachy, L. C., Padayachy, V., Galal, U., Gray, R., & Fieggen, A. G. (2016). The relationship between transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children : Part I: repeatability, observer variability and general analysis. Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery, 32(10), 1769-78. https://doi.org/10.1007/s00381-016-3067-5
Padayachy LC, et al. The Relationship Between Transorbital Ultrasound Measurement of the Optic Nerve Sheath Diameter (ONSD) and Invasively Measured ICP in Children : Part I: Repeatability, Observer Variability and General Analysis. Childs Nerv Syst. 2016;32(10):1769-78. PubMed PMID: 27659819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children : Part I: repeatability, observer variability and general analysis. AU - Padayachy,Llewellyn C, AU - Padayachy,Vaishali, AU - Galal,Ushma, AU - Gray,Rebecca, AU - Fieggen,A Graham, Y1 - 2016/09/20/ PY - 2015/12/22/received PY - 2016/03/14/accepted PY - 2016/9/24/entrez PY - 2016/9/24/pubmed PY - 2017/2/22/medline KW - ICP monitoring KW - Non-invasive KW - Optic nerve sheath diameter KW - Ultrasound SP - 1769 EP - 78 JF - Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery JO - Childs Nerv Syst VL - 32 IS - 10 N2 - PURPOSE: The aim of this study was to investigate the relationship between optic nerve sheath diameter (ONSD) measurement and invasively measured intracranial pressure (ICP) in children. METHODS: ONSD measurement was performed prior to invasive measurement of ICP. The mean binocular ONSD measurement was compared to the ICP reading. Physiological variables including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse rate, temperature, respiratory rate and end tidal carbon dioxide (ETCO2) level were recorded at the time of ONSD measurement. Diagnostic accuracy analysis was performed at various ICP thresholds and repeatability, intra- and inter-observer variability, correlation between measurements in different imaging planes as well the relationship over the entire patient cohort were examined in part I of this study. RESULTS: Data from 174 patients were analysed. Repeatability and intra-observer variability were excellent (α = 0.97-0.99). Testing for inter-observer variability revealed good correlation (r = 0.89, p < 0.001). Imaging in the sagittal plane demonstrated a slightly better correlation with ICP (r = 0.66, p < 0.001). The ONSD measurement with the best diagnostic accuracy for detecting an ICP ≥ 20 mmHg over the entire patient cohort was 5.5 mm, sensitivity 93.2 %, specificity 74 % and odds ratio (OR) of 39.3. CONCLUSION: Transorbital ultrasound measurement of the OSND is a reliable and reproducible technique, demonstrating a good relationship with ICP and high diagnostic accuracy for detecting raised ICP. SN - 1433-0350 UR - https://www.unboundmedicine.com/medline/citation/27659819/The_relationship_between_transorbital_ultrasound_measurement_of_the_optic_nerve_sheath_diameter__ONSD__and_invasively_measured_ICP_in_children_:_Part_I:_repeatability_observer_variability_and_general_analysis_ L2 - https://dx.doi.org/10.1007/s00381-016-3067-5 DB - PRIME DP - Unbound Medicine ER -