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Morin and Its Role in Chronic Diseases.
Adv Exp Med Biol. 2016; 928:453-471.AE

Abstract

Chronic diseases can be referred to the long-term medical conditions which are mostly progressive in nature, i.e., it deteriorates over time. Diabetes, arthritis, heart disease, stroke, cancer, and chronic respiratory problems (e.g., COPD) are not a few examples of chronic diseases and chronic diseases are the leading causes of death and disability all over the world. Chronic diseases and conditions are among the most common, costly, and preventable of all health problems. Affordable cost, presence mostly in the consumables, and minimal side effects make the naturally occurring compounds interesting and attractive for pharmacological study in recent years. Plants produce diverse types of low molecular weight products mainly for the defense purpose. Among them, the group of secondary metabolites related to a polyphenolic group has been named flavonoids and are of great interest due to their incredible pharmacological properties. In these regard, due to its potent anti-inflammatory, anti-apoptotic and many important pharmacological properties (relevant to chronic diseases, e.g., urate transporter inhibitor related to gout, modulator of immunosystem related to chronic hypersensitivity, etc.), morin [morin hydrate:2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopy ran-4-one; 3,5,7,20,40 pentahydroxyflavone], widely found among the Moraceae family, considered as one of the most important key bioflavonols. However, little is known about the molecular mechanisms of its action on such conditions. In this chapter, we have summarized most of the findings, if not all, available till date.

Authors+Show Affiliations

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, 700054, West Bengal, India. Department of Zoology, Jhargram Raj College, Government of West Bengal, Jhargram, 721507, West Bengal, India.Chemistry Department, Banwarilal Bhalotia College Asansol, Ushagram, Asansol, 713303, West Bengal, India.Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, 700054, West Bengal, India. parames@jcbose.ac.in.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27671828

Citation

Sinha, Krishnendu, et al. "Morin and Its Role in Chronic Diseases." Advances in Experimental Medicine and Biology, vol. 928, 2016, pp. 453-471.
Sinha K, Ghosh J, Sil PC. Morin and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:453-471.
Sinha, K., Ghosh, J., & Sil, P. C. (2016). Morin and Its Role in Chronic Diseases. Advances in Experimental Medicine and Biology, 928, 453-471.
Sinha K, Ghosh J, Sil PC. Morin and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:453-471. PubMed PMID: 27671828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morin and Its Role in Chronic Diseases. AU - Sinha,Krishnendu, AU - Ghosh,Jyotirmoy, AU - Sil,Parames C, PY - 2016/9/28/entrez PY - 2016/9/28/pubmed PY - 2017/6/2/medline KW - Anti-inflammatory KW - Antioxidant KW - Cellular signaling KW - Chronic diseases KW - Morin SP - 453 EP - 471 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 928 N2 - Chronic diseases can be referred to the long-term medical conditions which are mostly progressive in nature, i.e., it deteriorates over time. Diabetes, arthritis, heart disease, stroke, cancer, and chronic respiratory problems (e.g., COPD) are not a few examples of chronic diseases and chronic diseases are the leading causes of death and disability all over the world. Chronic diseases and conditions are among the most common, costly, and preventable of all health problems. Affordable cost, presence mostly in the consumables, and minimal side effects make the naturally occurring compounds interesting and attractive for pharmacological study in recent years. Plants produce diverse types of low molecular weight products mainly for the defense purpose. Among them, the group of secondary metabolites related to a polyphenolic group has been named flavonoids and are of great interest due to their incredible pharmacological properties. In these regard, due to its potent anti-inflammatory, anti-apoptotic and many important pharmacological properties (relevant to chronic diseases, e.g., urate transporter inhibitor related to gout, modulator of immunosystem related to chronic hypersensitivity, etc.), morin [morin hydrate:2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopy ran-4-one; 3,5,7,20,40 pentahydroxyflavone], widely found among the Moraceae family, considered as one of the most important key bioflavonols. However, little is known about the molecular mechanisms of its action on such conditions. In this chapter, we have summarized most of the findings, if not all, available till date. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/27671828/Morin_and_Its_Role_in_Chronic_Diseases_ L2 - https://dx.doi.org/10.1007/978-3-319-41334-1_19 DB - PRIME DP - Unbound Medicine ER -