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MicroRNA-98 acts as a tumor suppressor in hepatocellular carcinoma via targeting SALL4.
Oncotarget. 2016 Nov 08; 7(45):74059-74073.O

Abstract

MicroRNAs (miRs) are involved in the development and progression of hepatocellular carcinoma (HCC), but the regulatory mechanism of miR-98 in HCC still remains unclear. Here we found that miR-98 was significantly downregulated in HCC tissues compared to matched adjacent normal tissues (ANTs). Low miR-98 expression was associated with tumor size, metastasis, portal vein tumor embolus, and poor overall survival. Ectopic expression of miR-98 decreased the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of HCC cells. SALL4 was identified as a novel target of miR-98, and the protein expression of SALL4 was inhibited by miR-98 in HCC cells. Overexpression of SALL4 reversed the suppressive effects of miR-98 on the malignant phenotypes of HCC cells. Besides, SALL4, upregulated in HCC tissues compared to the matched ANTs, was inversely correlated to the miR-98 levels in HCC tissues. In addition, overexpression of miR-98 markedly suppressed the tumor growth as well as tumor-induced death in nude mice. In summary, miR-98 plays a suppressive role in the proliferation, migration, invasion and EMT of HCC cells, partly at least, via directly inhibition of SALL4. Therefore, the miR-98/SALL4 axis may become a promising therapeutic target for HCC.

Authors+Show Affiliations

Department of Hepatobillary Surgery, Shandong Cancer Hospital, Jinan, Shandong 250117, P.R. China.Department of Urology Surgery, Shandong Cancer Hospital, Jinan, Shandong 250117, P.R. China.Clinical Laboratory, Shandong Cancer Hospital, Jinan, Shandong 250117, P.R. China.Department of Hepatobillary Surgery, Shandong Cancer Hospital, Jinan, Shandong 250117, P.R. China.Department of Hepatobillary Surgery, Shandong Cancer Hospital, Jinan, Shandong 250117, P.R. China.Department of Radiation Oncology, Shandong Cancer Hospital, Jinan, Shandong 250117, P.R. China.Department of Intervention Therapy, Shandong Cancer Hospital, Jinan, Shandong 250117, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27677076

Citation

Zhou, Wuyuan, et al. "MicroRNA-98 Acts as a Tumor Suppressor in Hepatocellular Carcinoma Via Targeting SALL4." Oncotarget, vol. 7, no. 45, 2016, pp. 74059-74073.
Zhou W, Zou B, Liu L, et al. MicroRNA-98 acts as a tumor suppressor in hepatocellular carcinoma via targeting SALL4. Oncotarget. 2016;7(45):74059-74073.
Zhou, W., Zou, B., Liu, L., Cui, K., Gao, J., Yuan, S., & Cong, N. (2016). MicroRNA-98 acts as a tumor suppressor in hepatocellular carcinoma via targeting SALL4. Oncotarget, 7(45), 74059-74073. https://doi.org/10.18632/oncotarget.12190
Zhou W, et al. MicroRNA-98 Acts as a Tumor Suppressor in Hepatocellular Carcinoma Via Targeting SALL4. Oncotarget. 2016 Nov 8;7(45):74059-74073. PubMed PMID: 27677076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNA-98 acts as a tumor suppressor in hepatocellular carcinoma via targeting SALL4. AU - Zhou,Wuyuan, AU - Zou,Benkui, AU - Liu,Lisheng, AU - Cui,Kai, AU - Gao,Jie, AU - Yuan,Shuanghu, AU - Cong,Ning, PY - 2016/06/22/received PY - 2016/08/16/accepted PY - 2016/9/28/pubmed PY - 2018/3/23/medline PY - 2016/9/28/entrez KW - SALL4 KW - hepatocellular carcinoma KW - microRNA-98 KW - tumor suppressor SP - 74059 EP - 74073 JF - Oncotarget JO - Oncotarget VL - 7 IS - 45 N2 - MicroRNAs (miRs) are involved in the development and progression of hepatocellular carcinoma (HCC), but the regulatory mechanism of miR-98 in HCC still remains unclear. Here we found that miR-98 was significantly downregulated in HCC tissues compared to matched adjacent normal tissues (ANTs). Low miR-98 expression was associated with tumor size, metastasis, portal vein tumor embolus, and poor overall survival. Ectopic expression of miR-98 decreased the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of HCC cells. SALL4 was identified as a novel target of miR-98, and the protein expression of SALL4 was inhibited by miR-98 in HCC cells. Overexpression of SALL4 reversed the suppressive effects of miR-98 on the malignant phenotypes of HCC cells. Besides, SALL4, upregulated in HCC tissues compared to the matched ANTs, was inversely correlated to the miR-98 levels in HCC tissues. In addition, overexpression of miR-98 markedly suppressed the tumor growth as well as tumor-induced death in nude mice. In summary, miR-98 plays a suppressive role in the proliferation, migration, invasion and EMT of HCC cells, partly at least, via directly inhibition of SALL4. Therefore, the miR-98/SALL4 axis may become a promising therapeutic target for HCC. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/27677076/MicroRNA_98_acts_as_a_tumor_suppressor_in_hepatocellular_carcinoma_via_targeting_SALL4_ L2 - http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=12190 DB - PRIME DP - Unbound Medicine ER -