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Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study.
Medicine (Baltimore) 2016; 95(39):e4892M

Abstract

The study aimed to evaluate the therapeutic effects of deep anterior lamellar keratoplasty (DALK) using glycerol-cryopreserved corneal tissues (GCCTs) in patients with refractive herpes simplex keratitis (HSK). This article was a retrospective, noncomparative, and interventional case series. Patients with HSK underwent DALK using GCCTs at Shanghai Tongji Hospital from 2012 to 2015. The best spectacle corrected visual acuity, recurrent inflammation, graft status, postoperative central graft thickness, and pre/postoperative complications were detected. The follow-up ranged from 24.4 ± 5.6 months (range: 16-38 months). Overall, the best spectacle corrected visual acuity was increased from HM/10 cm to 0.15 before surgery to 0.41 ± 0.14 (range: 0.1-0.8; P < 0.05) at 12 months postoperatively. Intraoperative microperforation occurred in 4 eyes (14.81%), and rejection episodes were encountered in 3 of 27 eyes (11.1%), and all of the eyes reversed. HSK recurred in 2 eyes (7.41%), 1 eye with repeated recurring HSK, and eventually led to perpetual corneal opacity and the patient refused a retransplantation. The mean entire corneal thickness was 0.519 ± 0.018 mm (range: 0.5-0.56 mm) and the mean graft thickness was 0.405 ± 0.033 mm (range: 0.35-0.47 mm) in the final follow-up. The DALK using GCCTs was proven to be an effective and safe therapy in treating refractory HSK.

Authors+Show Affiliations

aDepartment of Ophthalmology, Tongji Hospital Affiliated with Tongji University School of Medicine, Shanghai bDepartment of Ophthalmology, Guizhou provincial people's hospital, Guiyang, Guizhou, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

27684823

Citation

Liu, Xin, et al. "Clinical Evaluation of Deep Anterior Lamellar Keratoplasty Using Glycerol-cryopreserved Corneal Tissues for Refractory Herpetic Stromal Keratitis: an Observational Study." Medicine, vol. 95, no. 39, 2016, pp. e4892.
Liu X, Zhou Q, Huang X, et al. Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. Medicine (Baltimore). 2016;95(39):e4892.
Liu, X., Zhou, Q., Huang, X., Liu, Z., & Bi, Y. (2016). Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. Medicine, 95(39), pp. e4892. doi:10.1097/MD.0000000000004892.
Liu X, et al. Clinical Evaluation of Deep Anterior Lamellar Keratoplasty Using Glycerol-cryopreserved Corneal Tissues for Refractory Herpetic Stromal Keratitis: an Observational Study. Medicine (Baltimore). 2016;95(39):e4892. PubMed PMID: 27684823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. AU - Liu,Xin, AU - Zhou,Qi, AU - Huang,Xinyu, AU - Liu,Zhenxing, AU - Bi,Yanlong, PY - 2016/9/30/entrez PY - 2016/9/30/pubmed PY - 2017/2/16/medline SP - e4892 EP - e4892 JF - Medicine JO - Medicine (Baltimore) VL - 95 IS - 39 N2 - The study aimed to evaluate the therapeutic effects of deep anterior lamellar keratoplasty (DALK) using glycerol-cryopreserved corneal tissues (GCCTs) in patients with refractive herpes simplex keratitis (HSK). This article was a retrospective, noncomparative, and interventional case series. Patients with HSK underwent DALK using GCCTs at Shanghai Tongji Hospital from 2012 to 2015. The best spectacle corrected visual acuity, recurrent inflammation, graft status, postoperative central graft thickness, and pre/postoperative complications were detected. The follow-up ranged from 24.4 ± 5.6 months (range: 16-38 months). Overall, the best spectacle corrected visual acuity was increased from HM/10 cm to 0.15 before surgery to 0.41 ± 0.14 (range: 0.1-0.8; P < 0.05) at 12 months postoperatively. Intraoperative microperforation occurred in 4 eyes (14.81%), and rejection episodes were encountered in 3 of 27 eyes (11.1%), and all of the eyes reversed. HSK recurred in 2 eyes (7.41%), 1 eye with repeated recurring HSK, and eventually led to perpetual corneal opacity and the patient refused a retransplantation. The mean entire corneal thickness was 0.519 ± 0.018 mm (range: 0.5-0.56 mm) and the mean graft thickness was 0.405 ± 0.033 mm (range: 0.35-0.47 mm) in the final follow-up. The DALK using GCCTs was proven to be an effective and safe therapy in treating refractory HSK. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/27684823/Clinical_evaluation_of_deep_anterior_lamellar_keratoplasty_using_glycerol_cryopreserved_corneal_tissues_for_refractory_herpetic_stromal_keratitis:_An_observational_study_ L2 - http://Insights.ovid.com/pubmed?pmid=27684823 DB - PRIME DP - Unbound Medicine ER -