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Erythrocyte uroporphyrinogen decarboxylase activity in porphyria cutanea tarda: a study of 40 consecutive patients.
J Invest Dermatol 1989; 93(3):332-4JI

Abstract

We measured uroporphyrinogen decarboxylase (UROD) activity in erythrocyte lysates obtained from 40 consecutive patients with porphyria cutanea tarda (PCT) without selection for family history. Enzyme determinations indicated that 28% of the patients had abnormally decreased UROD activity in erythrocytes; this finding did not always correlate with family history. Two siblings with PCT and normal erythrocytic, but abnormally decreased hepatic UROD activities, were encountered. This finding suggests that familial PCT may occur not only with decreased erythrocyte UROD activity, but also with a normal UROD activity in erythrocytes.

Authors+Show Affiliations

Department of Dermatology, Columbia-Presbyterian Medical Center, New York, NY 10032.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2768832

Citation

Held, J L., et al. "Erythrocyte Uroporphyrinogen Decarboxylase Activity in Porphyria Cutanea Tarda: a Study of 40 Consecutive Patients." The Journal of Investigative Dermatology, vol. 93, no. 3, 1989, pp. 332-4.
Held JL, Sassa S, Kappas A, et al. Erythrocyte uroporphyrinogen decarboxylase activity in porphyria cutanea tarda: a study of 40 consecutive patients. J Invest Dermatol. 1989;93(3):332-4.
Held, J. L., Sassa, S., Kappas, A., & Harber, L. C. (1989). Erythrocyte uroporphyrinogen decarboxylase activity in porphyria cutanea tarda: a study of 40 consecutive patients. The Journal of Investigative Dermatology, 93(3), pp. 332-4.
Held JL, et al. Erythrocyte Uroporphyrinogen Decarboxylase Activity in Porphyria Cutanea Tarda: a Study of 40 Consecutive Patients. J Invest Dermatol. 1989;93(3):332-4. PubMed PMID: 2768832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocyte uroporphyrinogen decarboxylase activity in porphyria cutanea tarda: a study of 40 consecutive patients. AU - Held,J L, AU - Sassa,S, AU - Kappas,A, AU - Harber,L C, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 332 EP - 4 JF - The Journal of investigative dermatology JO - J. Invest. Dermatol. VL - 93 IS - 3 N2 - We measured uroporphyrinogen decarboxylase (UROD) activity in erythrocyte lysates obtained from 40 consecutive patients with porphyria cutanea tarda (PCT) without selection for family history. Enzyme determinations indicated that 28% of the patients had abnormally decreased UROD activity in erythrocytes; this finding did not always correlate with family history. Two siblings with PCT and normal erythrocytic, but abnormally decreased hepatic UROD activities, were encountered. This finding suggests that familial PCT may occur not only with decreased erythrocyte UROD activity, but also with a normal UROD activity in erythrocytes. SN - 0022-202X UR - https://www.unboundmedicine.com/medline/citation/2768832/Erythrocyte_uroporphyrinogen_decarboxylase_activity_in_porphyria_cutanea_tarda:_a_study_of_40_consecutive_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0022-202X(89)90053-5 DB - PRIME DP - Unbound Medicine ER -