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Evaluation of myeloid cells (tumor-associated tissue eosinophils and mast cells) infiltration in different grades of oral squamous cell carcinoma.
Indian J Med Paediatr Oncol. 2016 Jul-Sep; 37(3):158-67.IJ

Abstract

BACKGROUND

The multifunctional involvement and infiltration of myeloid cells (tumor-associated tissue eosinophils [TATE] and mast cells) can provide a unique opportunity to define relevant effectors functions that may represent novel, therapeutic options for modulation of tumor onset/growth.

AIM

Our study aimed to evaluate infiltration of myeloid cells (TATE and Mast cells) infiltration in different grades (WHO grading) of oral squamous cell carcinoma (OSCC).

MATERIALS AND METHODS

Total 30 cases of OSCC were selected for this study. Hematoxylin and eosin stain and toluidine blue special stain, to evaluate TATE and the mast cells infiltration, were used. Three-year follow-up of OSCC cases was done.

RESULT

Among 30 cases, 63.33% cases of OSCC showed TATE-positive and 36.66% cases showed TATE-negative. Regarding mast cells infiltration, 66.66% OSCC cases showed mast cells positive and 33.33% cases did not show significant mast cells infiltration. We found significant association of TATE and mast cells infiltration in OSCC cases. These myeloid cells infiltration significantly associated with age of patients but did not show any significant association with gender, site, and habit of cases. When we compared these cells infiltration with clinical stages and different histological grades of tumor, we found their infiltration is decreasing, from Stages 1 to Stage 3 of tumor and from well to poorly differentiated carcinoma. We have also found the less infiltration of these myeloid in recurrence cases of OSCC.

CONCLUSION

As the infiltration of TATE and mast cells are correlated, along with evaluation of TATE, we should also evaluate the presence of mast cells infiltration in OSCC. The assessment of myeloid cells could become, in the future, useful for therapeutic approaches in this subset of the patient.

Authors+Show Affiliations

Department of Oral and Maxillofacial Pathology, Institute of Dental Science, SOA University, Bhubaneswar, Odisha, India.Department of Oral Medicine and Radiology, S.C.B. Dental College and Hospital, Cuttack, Odisha, India.Department of Oral and Maxillofacial Pathology, SPDC, Sawangi, Wardha, Maharashtra, India.Department of Oral and Maxillofacial Pathology, Aditya Dental College, Beed, Maharashtra, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27688609

Citation

Debta, Priyanka, et al. "Evaluation of Myeloid Cells (tumor-associated Tissue Eosinophils and Mast Cells) Infiltration in Different Grades of Oral Squamous Cell Carcinoma." Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology, vol. 37, no. 3, 2016, pp. 158-67.
Debta P, Debta FM, Chaudhary M, et al. Evaluation of myeloid cells (tumor-associated tissue eosinophils and mast cells) infiltration in different grades of oral squamous cell carcinoma. Indian J Med Paediatr Oncol. 2016;37(3):158-67.
Debta, P., Debta, F. M., Chaudhary, M., & Bussari, S. (2016). Evaluation of myeloid cells (tumor-associated tissue eosinophils and mast cells) infiltration in different grades of oral squamous cell carcinoma. Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology, 37(3), 158-67. https://doi.org/10.4103/0971-5851.190349
Debta P, et al. Evaluation of Myeloid Cells (tumor-associated Tissue Eosinophils and Mast Cells) Infiltration in Different Grades of Oral Squamous Cell Carcinoma. Indian J Med Paediatr Oncol. 2016 Jul-Sep;37(3):158-67. PubMed PMID: 27688609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of myeloid cells (tumor-associated tissue eosinophils and mast cells) infiltration in different grades of oral squamous cell carcinoma. AU - Debta,Priyanka, AU - Debta,Fakir Mohan, AU - Chaudhary,Minal, AU - Bussari,Smita, PY - 2016/10/1/entrez PY - 2016/10/1/pubmed PY - 2016/10/1/medline KW - Mast cells KW - oral squamous cell carcinoma KW - toluidine blue KW - tumor-associated tissue eosinophils SP - 158 EP - 67 JF - Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology JO - Indian J Med Paediatr Oncol VL - 37 IS - 3 N2 - BACKGROUND: The multifunctional involvement and infiltration of myeloid cells (tumor-associated tissue eosinophils [TATE] and mast cells) can provide a unique opportunity to define relevant effectors functions that may represent novel, therapeutic options for modulation of tumor onset/growth. AIM: Our study aimed to evaluate infiltration of myeloid cells (TATE and Mast cells) infiltration in different grades (WHO grading) of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: Total 30 cases of OSCC were selected for this study. Hematoxylin and eosin stain and toluidine blue special stain, to evaluate TATE and the mast cells infiltration, were used. Three-year follow-up of OSCC cases was done. RESULT: Among 30 cases, 63.33% cases of OSCC showed TATE-positive and 36.66% cases showed TATE-negative. Regarding mast cells infiltration, 66.66% OSCC cases showed mast cells positive and 33.33% cases did not show significant mast cells infiltration. We found significant association of TATE and mast cells infiltration in OSCC cases. These myeloid cells infiltration significantly associated with age of patients but did not show any significant association with gender, site, and habit of cases. When we compared these cells infiltration with clinical stages and different histological grades of tumor, we found their infiltration is decreasing, from Stages 1 to Stage 3 of tumor and from well to poorly differentiated carcinoma. We have also found the less infiltration of these myeloid in recurrence cases of OSCC. CONCLUSION: As the infiltration of TATE and mast cells are correlated, along with evaluation of TATE, we should also evaluate the presence of mast cells infiltration in OSCC. The assessment of myeloid cells could become, in the future, useful for therapeutic approaches in this subset of the patient. SN - 0971-5851 UR - https://www.unboundmedicine.com/medline/citation/27688609/Evaluation_of_myeloid_cells__tumor_associated_tissue_eosinophils_and_mast_cells__infiltration_in_different_grades_of_oral_squamous_cell_carcinoma_ L2 - http://www.ijmpo.org/article.asp?issn=0971-5851;year=2016;volume=37;issue=3;spage=158;epage=167;aulast=Debta DB - PRIME DP - Unbound Medicine ER -
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