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Acaricidal efficacies of Lippia gracilis essential oil and its phytochemicals against organophosphate-resistant and susceptible strains of Rhipicephalus (Boophilus) microplus.
Vet Parasitol. 2016 Sep 15; 228:60-64.VP

Abstract

Plant-derived natural products can serve as an alternative to synthetic compounds for control of ticks of veterinary and medical importance. Lippia gracilis is an aromatic plant that produces essential oil with high content of carvacrol and thymol monoterpenes. These monoterpenes have high acaricidal activity against Rhipicephalus (Boophilus) microplus. However, there are no studies that show efficacy differences of essential oils between susceptible and organophosphate resistant strains of R. (B.) microplus. The aim of the present study was to compare acaricidal effects of essential oils extracted from two different genotypes of L. gracilis and the main monoterpenes on larvae of both susceptible and organophosphate resistant R. (B.) microplus larvae. The efficacy of the essential oil of two genotypes of L. gracilis (106 and 201) and their monoterpenes carvacrol and thymol was measured using the larval immersion test on coumaphos-resistant and susceptible strains of R. (B.) microplus. Lethal concentrations were calculated using GraphPad Prism 6.0. Chemical analysis was performed by GC-MS and FID. Thymol and carvacrol were observed to be major constituents in 106 and 201L. gracilis genotype essential oils, respectively. Essential oils of both genotypes were more effective against organophosphate-resistant tick strain than susceptible tick strain. Carvacrol was 3.2 times more toxic to organophosphate resistant strain than to susceptible strain. Thymol was equally toxic to resistant and susceptible tick strains. The significantly higher efficacy monoterpene carvacrol against resistant ticks may lead to development of new natural product acaricide formulations for use to control organophosphate resistant R. (B.) microplus populations.

Authors+Show Affiliations

Pathology Department, Federal University of Maranhão, Brazil. Electronic address: livio.martins@ufma.br.Cattle Fever Tick Research Laboratory, Agricultural Research Service, USDA, United States.Chemistry Department, Federal University of Sergipe, Brazil.Agronomy Department, Federal University of Sergipe, Brazil.Invasive Insect Biocontrol and Behavior Laboratory, Agricultural Research Service, USDA, United States.Knipling-Bushland U.S. Livestock Insects Research Laboratory, and Veterinary Pest Genomics Center, Agricultural Research Service, USDA, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27692332

Citation

Costa-Júnior, Livio M., et al. "Acaricidal Efficacies of Lippia Gracilis Essential Oil and Its Phytochemicals Against Organophosphate-resistant and Susceptible Strains of Rhipicephalus (Boophilus) Microplus." Veterinary Parasitology, vol. 228, 2016, pp. 60-64.
Costa-Júnior LM, Miller RJ, Alves PB, et al. Acaricidal efficacies of Lippia gracilis essential oil and its phytochemicals against organophosphate-resistant and susceptible strains of Rhipicephalus (Boophilus) microplus. Vet Parasitol. 2016;228:60-64.
Costa-Júnior, L. M., Miller, R. J., Alves, P. B., Blank, A. F., Li, A. Y., & Pérez de León, A. A. (2016). Acaricidal efficacies of Lippia gracilis essential oil and its phytochemicals against organophosphate-resistant and susceptible strains of Rhipicephalus (Boophilus) microplus. Veterinary Parasitology, 228, 60-64. https://doi.org/10.1016/j.vetpar.2016.05.028
Costa-Júnior LM, et al. Acaricidal Efficacies of Lippia Gracilis Essential Oil and Its Phytochemicals Against Organophosphate-resistant and Susceptible Strains of Rhipicephalus (Boophilus) Microplus. Vet Parasitol. 2016 Sep 15;228:60-64. PubMed PMID: 27692332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acaricidal efficacies of Lippia gracilis essential oil and its phytochemicals against organophosphate-resistant and susceptible strains of Rhipicephalus (Boophilus) microplus. AU - Costa-Júnior,Livio M, AU - Miller,Robert J, AU - Alves,Péricles B, AU - Blank,Arie F, AU - Li,Andrew Y, AU - Pérez de León,Adalberto A, Y1 - 2016/05/24/ PY - 2015/11/23/received PY - 2016/05/20/revised PY - 2016/05/23/accepted PY - 2016/10/4/entrez PY - 2016/10/4/pubmed PY - 2017/7/1/medline KW - Acaricide KW - Botanical KW - Carvacrol KW - Organophosphate KW - Resistance KW - Thymol SP - 60 EP - 64 JF - Veterinary parasitology JO - Vet. Parasitol. VL - 228 N2 - Plant-derived natural products can serve as an alternative to synthetic compounds for control of ticks of veterinary and medical importance. Lippia gracilis is an aromatic plant that produces essential oil with high content of carvacrol and thymol monoterpenes. These monoterpenes have high acaricidal activity against Rhipicephalus (Boophilus) microplus. However, there are no studies that show efficacy differences of essential oils between susceptible and organophosphate resistant strains of R. (B.) microplus. The aim of the present study was to compare acaricidal effects of essential oils extracted from two different genotypes of L. gracilis and the main monoterpenes on larvae of both susceptible and organophosphate resistant R. (B.) microplus larvae. The efficacy of the essential oil of two genotypes of L. gracilis (106 and 201) and their monoterpenes carvacrol and thymol was measured using the larval immersion test on coumaphos-resistant and susceptible strains of R. (B.) microplus. Lethal concentrations were calculated using GraphPad Prism 6.0. Chemical analysis was performed by GC-MS and FID. Thymol and carvacrol were observed to be major constituents in 106 and 201L. gracilis genotype essential oils, respectively. Essential oils of both genotypes were more effective against organophosphate-resistant tick strain than susceptible tick strain. Carvacrol was 3.2 times more toxic to organophosphate resistant strain than to susceptible strain. Thymol was equally toxic to resistant and susceptible tick strains. The significantly higher efficacy monoterpene carvacrol against resistant ticks may lead to development of new natural product acaricide formulations for use to control organophosphate resistant R. (B.) microplus populations. SN - 1873-2550 UR - https://www.unboundmedicine.com/medline/citation/27692332/Acaricidal_efficacies_of_Lippia_gracilis_essential_oil_and_its_phytochemicals_against_organophosphate_resistant_and_susceptible_strains_of_Rhipicephalus__Boophilus__microplus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(16)30193-5 DB - PRIME DP - Unbound Medicine ER -