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Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders.
Br J Pharmacol. 2017 06; 174(11):1426-1449.BJ

Abstract

Functional bowel disorders (FBD), mainly irritable bowel syndrome (IBS) and functional constipation (FC, also called chronic idiopathic constipation), are very common worldwide. Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, although less common, has a strong impact on patients' quality of life, as well as being highly expensive for our healthcare. A definite cure for those disorders is still yet to come. Over the years, several therapeutic approaches complementary or alternative to traditional pharmacological treatments, including probiotics, prebiotics, synbiotics, fibre and herbal medicinal products, have been investigated for the management of both groups of diseases. However, most available studies are biased by several drawbacks, including small samples and poor methodological quality. Probiotics, in particular Saccharomyces boulardii and Lactobacilli (among which Lactobacillus rhamnosus), synbiotics, psyllium, and some herbal medicinal products, primarily peppermint oil, seem to be effective in ameliorating IBS symptoms. Synbiotics and fibre seem to be beneficial in FC patients. The probiotic combination VSL#3 may be effective in inducing remission in patients with mild-to-moderate ulcerative colitis, in whom Escherichia coli Nissle 1917 seems to be as effective as mesalamine in maintaining remission. No definite conclusions can be drawn as to the efficacy of fibre and herbal medicinal products in IBD patients due to the low number of studies and the lack of randomized controlled trials that replicate the results obtained in the individual studies conducted so far. Thus, further, well-designed studies are needed to address the real role of these therapeutic options in the management of both FBD and IBD.

LINKED ARTICLES

This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc.

Authors+Show Affiliations

Institute of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L.go F. Vito 1, 00168, Rome, Italy.Department of Internal Medicine, School of Medicine, Catholic University of the Sacred Heart, L.go F. Vito 1, 00168, Rome, Italy.Department of Internal Medicine, School of Medicine, Catholic University of the Sacred Heart, L.go F. Vito 1, 00168, Rome, Italy.Department of Clinical and Experimental Medicine, University of Sassari, V.le S. Pietro, 8, 07100, Sassari, Italy.Department of Internal Medicine, School of Medicine, Catholic University of the Sacred Heart, L.go F. Vito 1, 00168, Rome, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27696378

Citation

Currò, Diego, et al. "Probiotics, Fibre and Herbal Medicinal Products for Functional and Inflammatory Bowel Disorders." British Journal of Pharmacology, vol. 174, no. 11, 2017, pp. 1426-1449.
Currò D, Ianiro G, Pecere S, et al. Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders. Br J Pharmacol. 2017;174(11):1426-1449.
Currò, D., Ianiro, G., Pecere, S., Bibbò, S., & Cammarota, G. (2017). Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders. British Journal of Pharmacology, 174(11), 1426-1449. https://doi.org/10.1111/bph.13632
Currò D, et al. Probiotics, Fibre and Herbal Medicinal Products for Functional and Inflammatory Bowel Disorders. Br J Pharmacol. 2017;174(11):1426-1449. PubMed PMID: 27696378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders. AU - Currò,Diego, AU - Ianiro,Gianluca, AU - Pecere,Silvia, AU - Bibbò,Stefano, AU - Cammarota,Giovanni, Y1 - 2016/10/25/ PY - 2016/06/15/received PY - 2016/08/11/revised PY - 2016/09/13/accepted PY - 2016/10/27/pubmed PY - 2017/12/30/medline PY - 2016/10/4/entrez SP - 1426 EP - 1449 JF - British journal of pharmacology JO - Br. J. Pharmacol. VL - 174 IS - 11 N2 - : Functional bowel disorders (FBD), mainly irritable bowel syndrome (IBS) and functional constipation (FC, also called chronic idiopathic constipation), are very common worldwide. Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, although less common, has a strong impact on patients' quality of life, as well as being highly expensive for our healthcare. A definite cure for those disorders is still yet to come. Over the years, several therapeutic approaches complementary or alternative to traditional pharmacological treatments, including probiotics, prebiotics, synbiotics, fibre and herbal medicinal products, have been investigated for the management of both groups of diseases. However, most available studies are biased by several drawbacks, including small samples and poor methodological quality. Probiotics, in particular Saccharomyces boulardii and Lactobacilli (among which Lactobacillus rhamnosus), synbiotics, psyllium, and some herbal medicinal products, primarily peppermint oil, seem to be effective in ameliorating IBS symptoms. Synbiotics and fibre seem to be beneficial in FC patients. The probiotic combination VSL#3 may be effective in inducing remission in patients with mild-to-moderate ulcerative colitis, in whom Escherichia coli Nissle 1917 seems to be as effective as mesalamine in maintaining remission. No definite conclusions can be drawn as to the efficacy of fibre and herbal medicinal products in IBD patients due to the low number of studies and the lack of randomized controlled trials that replicate the results obtained in the individual studies conducted so far. Thus, further, well-designed studies are needed to address the real role of these therapeutic options in the management of both FBD and IBD. LINKED ARTICLES: This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc. SN - 1476-5381 UR - https://www.unboundmedicine.com/medline/citation/27696378/Probiotics_fibre_and_herbal_medicinal_products_for_functional_and_inflammatory_bowel_disorders_ L2 - https://doi.org/10.1111/bph.13632 DB - PRIME DP - Unbound Medicine ER -