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Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia.
J Pharm Pharmacol. 2016 Dec; 68(12):1597-1603.JP

Abstract

OBJECTIVES

This study aims to investigate xanthine oxidase (XO) inhibitory activity and antihyperuricemic effects of Corylopsis coreana Uyeki flos extracts and the phytochemicals contained therein.

METHODS

Ethanolic extracts of the plant were prepared, and the extraction process was optimized with respect to flavonoid content and XO inhibitory activity. The optimized ethanolic extract was tested for its XO inhibitory activity and antihyperuricemic effects in potassium oxonate-induced hyperuricemic mice.

KEY FINDINGS

The 80% ethanolic extract showed the highest total flavonoid content and in-vitro XO inhibitory activity. In-vivo studies demonstrated that the optimized 80% ethanolic extract could inhibit hepatic XO activity and significantly alleviate hyperuricemia at a relatively low oral dose (50 mg/kg) in mice. Additionally, an in-vitro enzyme inhibition study showed that phytochemicals such as bergenin, isosalipurposide, quercetin and quercitrin may be the key constituents responsible for the observed antihyperuricemic effects of the extract.

CONCLUSIONS

This study is the first report on the XO inhibitory and antihyperuricemic effects of C. coreana Uyeki flos extract, which can be therapeutically applied in treating hyperuricemia and gout.

Authors+Show Affiliations

Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam, Korea.Department of Oriental Medicine Materials, Dongshin University, Naju, Jeonnam, Korea.Department of Pharmacy, Chosun University, Gwangju, Korea.Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27696407

Citation

Yoon, In-Soo, et al. "Effects of Extracts From Corylopsis Coreana Uyeki (Hamamelidaceae) Flos On Xanthine Oxidase Activity and Hyperuricemia." The Journal of Pharmacy and Pharmacology, vol. 68, no. 12, 2016, pp. 1597-1603.
Yoon IS, Park DH, Ki SH, et al. Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia. J Pharm Pharmacol. 2016;68(12):1597-1603.
Yoon, I. S., Park, D. H., Ki, S. H., & Cho, S. S. (2016). Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia. The Journal of Pharmacy and Pharmacology, 68(12), 1597-1603. https://doi.org/10.1111/jphp.12626
Yoon IS, et al. Effects of Extracts From Corylopsis Coreana Uyeki (Hamamelidaceae) Flos On Xanthine Oxidase Activity and Hyperuricemia. J Pharm Pharmacol. 2016;68(12):1597-1603. PubMed PMID: 27696407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia. AU - Yoon,In-Soo, AU - Park,Dae-Hun, AU - Ki,Sung-Hwan, AU - Cho,Seung-Sik, Y1 - 2016/10/02/ PY - 2016/04/30/received PY - 2016/07/26/accepted PY - 2016/10/4/pubmed PY - 2017/5/17/medline PY - 2016/10/4/entrez KW - Corylopsis coreana Uyeki flos KW - gout KW - hyperuricemia KW - xanthine oxidase SP - 1597 EP - 1603 JF - The Journal of pharmacy and pharmacology JO - J. Pharm. Pharmacol. VL - 68 IS - 12 N2 - OBJECTIVES: This study aims to investigate xanthine oxidase (XO) inhibitory activity and antihyperuricemic effects of Corylopsis coreana Uyeki flos extracts and the phytochemicals contained therein. METHODS: Ethanolic extracts of the plant were prepared, and the extraction process was optimized with respect to flavonoid content and XO inhibitory activity. The optimized ethanolic extract was tested for its XO inhibitory activity and antihyperuricemic effects in potassium oxonate-induced hyperuricemic mice. KEY FINDINGS: The 80% ethanolic extract showed the highest total flavonoid content and in-vitro XO inhibitory activity. In-vivo studies demonstrated that the optimized 80% ethanolic extract could inhibit hepatic XO activity and significantly alleviate hyperuricemia at a relatively low oral dose (50 mg/kg) in mice. Additionally, an in-vitro enzyme inhibition study showed that phytochemicals such as bergenin, isosalipurposide, quercetin and quercitrin may be the key constituents responsible for the observed antihyperuricemic effects of the extract. CONCLUSIONS: This study is the first report on the XO inhibitory and antihyperuricemic effects of C. coreana Uyeki flos extract, which can be therapeutically applied in treating hyperuricemia and gout. SN - 2042-7158 UR - https://www.unboundmedicine.com/medline/citation/27696407/Effects_of_extracts_from_Corylopsis_coreana_Uyeki__Hamamelidaceae__flos_on_xanthine_oxidase_activity_and_hyperuricemia_ L2 - https://doi.org/10.1111/jphp.12626 DB - PRIME DP - Unbound Medicine ER -