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[Geographical distribution of mortality by Parkinson's disease and its association with air lead levels in Spain].
Med Clin (Barc). 2016 Dec 02; 147(11):481-487.MC

Abstract

BACKGROUND AND OBJECTIVE

Parkinson's disease (PD) is the second most common neurodegenerative disease, and the etiology of its sporadic form is unknown. The present study analyzes the temporal and spatial variations of mortality by PD in Spain over a period of 14 years and its relationship with lead concentration levels in the atmosphere.

METHOD

An ecological study was performed, in which deaths by PD and age group in 50 Spanish provinces between 2000 and 2013 were analyzed. The annual trend of PD mortality was assessed using the non-parametric Spearman's Rho test. Finally, the relationship between lead concentration levels in the air and mortality by PD was evaluated.

RESULTS

Between 2000 and 2013, 36,180 patients with PD died in Spain. There is an increasing trend in mortality through PD over the study period (P<.0001). La Rioja, Asturias, Basque Country and the Lower Ebro valley were the regions with the highest values of PD mortality. Those regions with the highest lead concentrations also showed higher mortality by this disease in people over 64 (P=.02).

CONCLUSIONS

Over our period of study, there has been an increase in mortality through PD in Spain, with the northernmost half of the country registering the highest values. Mortality in men was higher than mortality in women. Moreover, a direct correlation was found between lead levels in the air and mortality through PD.

Authors+Show Affiliations

Unidad de Medicina Legal, Departamento de Fisiología y Farmacología, Universidad de Cantabria, Santander, España. Electronic address: ana.santurtun@unican.es.Área de Investigación de Neurociencias, Instituto de Investigación Sanitaria Biodonostia, San Sebastián, Guipúzcoa, España.TICNOR S. L., Santander, España.Servicio de Neurología, Hospital Universitario Marqués de Valdecilla-IDIVAL (CIBERNED), Santander, España.

Pub Type(s)

Journal Article

Language

spa

PubMed ID

27697291

Citation

Santurtún, Ana, et al. "[Geographical Distribution of Mortality By Parkinson's Disease and Its Association With Air Lead Levels in Spain]." Medicina Clinica, vol. 147, no. 11, 2016, pp. 481-487.
Santurtún A, Delgado-Alvarado M, Villar A, et al. [Geographical distribution of mortality by Parkinson's disease and its association with air lead levels in Spain]. Med Clin (Barc). 2016;147(11):481-487.
Santurtún, A., Delgado-Alvarado, M., Villar, A., & Riancho, J. (2016). [Geographical distribution of mortality by Parkinson's disease and its association with air lead levels in Spain]. Medicina Clinica, 147(11), 481-487. https://doi.org/10.1016/j.medcli.2016.07.022
Santurtún A, et al. [Geographical Distribution of Mortality By Parkinson's Disease and Its Association With Air Lead Levels in Spain]. Med Clin (Barc). 2016 Dec 2;147(11):481-487. PubMed PMID: 27697291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Geographical distribution of mortality by Parkinson's disease and its association with air lead levels in Spain]. AU - Santurtún,Ana, AU - Delgado-Alvarado,Manuel, AU - Villar,Alejandro, AU - Riancho,Javier, Y1 - 2016/10/01/ PY - 2016/01/27/received PY - 2016/06/30/revised PY - 2016/07/13/accepted PY - 2016/10/5/pubmed PY - 2017/11/29/medline PY - 2016/10/5/entrez KW - Enfermedad de Parkinson KW - Lead KW - Material particulado KW - Parkinson's disease KW - Particulate matter KW - Plomo SP - 481 EP - 487 JF - Medicina clinica JO - Med Clin (Barc) VL - 147 IS - 11 N2 - BACKGROUND AND OBJECTIVE: Parkinson's disease (PD) is the second most common neurodegenerative disease, and the etiology of its sporadic form is unknown. The present study analyzes the temporal and spatial variations of mortality by PD in Spain over a period of 14 years and its relationship with lead concentration levels in the atmosphere. METHOD: An ecological study was performed, in which deaths by PD and age group in 50 Spanish provinces between 2000 and 2013 were analyzed. The annual trend of PD mortality was assessed using the non-parametric Spearman's Rho test. Finally, the relationship between lead concentration levels in the air and mortality by PD was evaluated. RESULTS: Between 2000 and 2013, 36,180 patients with PD died in Spain. There is an increasing trend in mortality through PD over the study period (P<.0001). La Rioja, Asturias, Basque Country and the Lower Ebro valley were the regions with the highest values of PD mortality. Those regions with the highest lead concentrations also showed higher mortality by this disease in people over 64 (P=.02). CONCLUSIONS: Over our period of study, there has been an increase in mortality through PD in Spain, with the northernmost half of the country registering the highest values. Mortality in men was higher than mortality in women. Moreover, a direct correlation was found between lead levels in the air and mortality through PD. SN - 1578-8989 UR - https://www.unboundmedicine.com/medline/citation/27697291/[Geographical_distribution_of_mortality_by_Parkinson's_disease_and_its_association_with_air_lead_levels_in_Spain]_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0025-7753(16)30370-0 DB - PRIME DP - Unbound Medicine ER -