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Plant phosphates, phytate and pathological calcifications in chronic kidney disease.
Nefrologia. 2017 Jan - Feb; 37(1):20-28.N

Abstract

Phytate, or myo-inositol 1,2,3,4,5,6-hexakis dihydrogen phosphate (InsP6), is a naturally occurring phosphorus compound that is present in many foods, mainly legumes, whole grains and nuts. Patients with chronic kidney disease (CKD) have cardiovascular disease mortality up to 30times higher than the general population. Vascular calcifications (VCs) directly contribute to overall morbidity and mortality, especially in CKD. In part, this high mortality is due to elevated levels of phosphorus in the blood. Therefore, control of dietary phosphorus is essential. Dietary phosphorus can be classified according to its structure in organic phosphorus (plant and animal) and inorganic (preservatives and additives). Plant-phosphorus (legumes and nuts), mainly associated with InsP6, is less absorbable by the human gastrointestinal tract as the bioavailability of phosphorous from plant-derived foods is very low. Recent data indicate that restriction of foods containing plant phosphates may compromise the adequate supply of nutrients that have a beneficial effect in preventing cardiovascular events, such as InsP6 or fibre found in legumes and nuts. Experimental studies in animals and observational studies in humans suggest that InsP6 can prevent lithiasis and VCs and protect from osteoporosis. In conclusion, we need prospective studies to elucidate the potential benefits and risks of phytate (InsP6) through the diet and as an intravenous drug in patients on haemodialysis.

Authors+Show Affiliations

Nefrología, Hospital Son Llàtzer, Palma de Mallorca, Baleares, España. Electronic address: juanm.buades@gmail.com.Laboratorio de Investigación en Litiasis Renal, Instituto de Ciencias de la Salud Investigación (IUNICS-IdISPa), Departamento de Química, Universidad de las Islas Baleares, Palma de Mallorca, Islas Baleares, España.Laboratoris Sanifit, ParcBIT, Palma de Mallorca, Islas Baleares, España.Laboratorio de Investigación en Litiasis Renal, Instituto de Ciencias de la Salud Investigación (IUNICS-IdISPa), Departamento de Química, Universidad de las Islas Baleares, Palma de Mallorca, Islas Baleares, España.

Pub Type(s)

Journal Article
Review

Language

eng spa

PubMed ID

27697413

Citation

Buades Fuster, Juan Manuel, et al. "Plant Phosphates, Phytate and Pathological Calcifications in Chronic Kidney Disease." Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia, vol. 37, no. 1, 2017, pp. 20-28.
Buades Fuster JM, Sanchís Cortés P, Perelló Bestard J, et al. Plant phosphates, phytate and pathological calcifications in chronic kidney disease. Nefrologia. 2017;37(1):20-28.
Buades Fuster, J. M., Sanchís Cortés, P., Perelló Bestard, J., & Grases Freixedas, F. (2017). Plant phosphates, phytate and pathological calcifications in chronic kidney disease. Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia, 37(1), 20-28. https://doi.org/10.1016/j.nefro.2016.07.001
Buades Fuster JM, et al. Plant Phosphates, Phytate and Pathological Calcifications in Chronic Kidney Disease. Nefrologia. 2017 Jan - Feb;37(1):20-28. PubMed PMID: 27697413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plant phosphates, phytate and pathological calcifications in chronic kidney disease. AU - Buades Fuster,Juan Manuel, AU - Sanchís Cortés,Pilar, AU - Perelló Bestard,Joan, AU - Grases Freixedas,Félix, Y1 - 2016/09/30/ PY - 2016/03/31/received PY - 2016/06/30/revised PY - 2016/07/23/accepted PY - 2016/10/5/pubmed PY - 2018/4/3/medline PY - 2016/10/5/entrez KW - Calcificaciones vasculares KW - Calcifilaxis KW - Calciphylaxis KW - Chronic kidney disease KW - Enfermedad renal crónica KW - Fitato KW - Hiperfosfatemia KW - Hyperphosphataemia KW - Phytate KW - Phytic acid KW - Vascular calcifications KW - Ácido fítico SP - 20 EP - 28 JF - Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia JO - Nefrologia VL - 37 IS - 1 N2 - Phytate, or myo-inositol 1,2,3,4,5,6-hexakis dihydrogen phosphate (InsP6), is a naturally occurring phosphorus compound that is present in many foods, mainly legumes, whole grains and nuts. Patients with chronic kidney disease (CKD) have cardiovascular disease mortality up to 30times higher than the general population. Vascular calcifications (VCs) directly contribute to overall morbidity and mortality, especially in CKD. In part, this high mortality is due to elevated levels of phosphorus in the blood. Therefore, control of dietary phosphorus is essential. Dietary phosphorus can be classified according to its structure in organic phosphorus (plant and animal) and inorganic (preservatives and additives). Plant-phosphorus (legumes and nuts), mainly associated with InsP6, is less absorbable by the human gastrointestinal tract as the bioavailability of phosphorous from plant-derived foods is very low. Recent data indicate that restriction of foods containing plant phosphates may compromise the adequate supply of nutrients that have a beneficial effect in preventing cardiovascular events, such as InsP6 or fibre found in legumes and nuts. Experimental studies in animals and observational studies in humans suggest that InsP6 can prevent lithiasis and VCs and protect from osteoporosis. In conclusion, we need prospective studies to elucidate the potential benefits and risks of phytate (InsP6) through the diet and as an intravenous drug in patients on haemodialysis. SN - 1989-2284 UR - https://www.unboundmedicine.com/medline/citation/27697413/Plant_phosphates_phytate_and_pathological_calcifications_in_chronic_kidney_disease_ L2 - http://www.revistanefrologia.com/es/linksolver/ft/pii/S0211-6995(16)30115-1 DB - PRIME DP - Unbound Medicine ER -