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Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature.
Exp Ther Med 2016; 12(4):2665-2670ET

Abstract

Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with sternoclavicular joint arthritis but without skin manifestations using multiple imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy. The first case was a 52-year-old male who suffered from progressive sternoclavicular arthritis for 2 years. The second case was a 62-year-old female with arthritis in the larger joints for 5 years, particularly on the right thoracic area. The third case was a 44-year-old male who exhibited a slight bulge accompanied by pain in the upper anterior chest wall for 4 years. All of them lacked cutaneous lesions. CT demonstrated sclerosis and hyperostosis with subchondral erosions in the sternocostoclavicular joints. MRI revealed bone marrow edema that was slightly hypointense on T1-weighted imaging, and hyperintense on T2-weighted imaging. Typical 'bull head' signs were observed in bone scintigraphy images. The present case study demonstrated that SAPHO syndrome should be suspected in patients with multifocal osteitis or arthritis affecting the chest wall that lack skin manifestations. Multimodal imaging modalities in combination are helpful for SAPHO diagnosis.

Authors+Show Affiliations

Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27698770

Citation

Duan, Na, et al. "Multimodal Imaging Findings of SAPHO Syndrome With No Skin Lesions: a Report of Three Cases and Review of the Literature." Experimental and Therapeutic Medicine, vol. 12, no. 4, 2016, pp. 2665-2670.
Duan N, Chen X, Liu Y, et al. Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature. Exp Ther Med. 2016;12(4):2665-2670.
Duan, N., Chen, X., Liu, Y., Wang, J., & Wang, Z. (2016). Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature. Experimental and Therapeutic Medicine, 12(4), pp. 2665-2670.
Duan N, et al. Multimodal Imaging Findings of SAPHO Syndrome With No Skin Lesions: a Report of Three Cases and Review of the Literature. Exp Ther Med. 2016;12(4):2665-2670. PubMed PMID: 27698770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature. AU - Duan,Na, AU - Chen,Xiao, AU - Liu,Yongkang, AU - Wang,Jianhua, AU - Wang,Zhongqiu, Y1 - 2016/09/08/ PY - 2015/06/03/received PY - 2016/07/28/accepted PY - 2016/10/5/entrez PY - 2016/10/5/pubmed PY - 2016/10/5/medline KW - imaging findings KW - sign synovitis acne pustulosis hyperostosis osteitis syndrome KW - ‘bull head’ SP - 2665 EP - 2670 JF - Experimental and therapeutic medicine JO - Exp Ther Med VL - 12 IS - 4 N2 - Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with sternoclavicular joint arthritis but without skin manifestations using multiple imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy. The first case was a 52-year-old male who suffered from progressive sternoclavicular arthritis for 2 years. The second case was a 62-year-old female with arthritis in the larger joints for 5 years, particularly on the right thoracic area. The third case was a 44-year-old male who exhibited a slight bulge accompanied by pain in the upper anterior chest wall for 4 years. All of them lacked cutaneous lesions. CT demonstrated sclerosis and hyperostosis with subchondral erosions in the sternocostoclavicular joints. MRI revealed bone marrow edema that was slightly hypointense on T1-weighted imaging, and hyperintense on T2-weighted imaging. Typical 'bull head' signs were observed in bone scintigraphy images. The present case study demonstrated that SAPHO syndrome should be suspected in patients with multifocal osteitis or arthritis affecting the chest wall that lack skin manifestations. Multimodal imaging modalities in combination are helpful for SAPHO diagnosis. SN - 1792-0981 UR - https://www.unboundmedicine.com/medline/citation/27698770/Multimodal_imaging_findings_of_SAPHO_syndrome_with_no_skin_lesions:_A_report_of_three_cases_and_review_of_the_literature_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1792-0981&volume=12&issue=4&spage=2665&aulast=Duan DB - PRIME DP - Unbound Medicine ER -