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Biomechanical Skin Property Evaluation for Wounds Treated With Synthetic and Biosynthetic Wound Dressings and a Newly Developed Collagen Matrix During Healing of Superficial Skin Defects in a Rat Models.
Wounds 2016; 28(9):334-340W

Abstract

INTRODUCTION

There is a high prevalence of superficial wounds such as partial-thickness burns. Treatment of these wounds frequently includes temporary application of wound dressings. The aim of this study was to compare a newly developed collagen matrix with commonly used temporary skin dressings for treatment of partial-thickness skin defects.

MATERIALS AND METHODS

Through a skin dermatome, 42 standardized superficial skin defects were generated on the back of 28 adult male Lewis rats. The wounds were treated with a synthetic wound dressing (Suprathel, Polymedics Innovations Inc, Woodstock, GA) (n = 14), a biosynthetic skin dressing (Biobrane, Smith & Nephew, Hull, UK) (n = 14), or a newly developed bovine collagen matrix, Collagen Cell Carrier (Viscofan BioEngineering, Weinheim, Germany) (n = 14). Biomechanical properties of the skin were determined and compared every 10 days over a 3-month period of using the Cutometer MPA 580 (Courage + Khazaka Electronic GmbH, Cologne, Germany).

RESULTS

As opposed to healthy skin, statistically significant differences were detected between days 10 and 30, and between days 60 and 80, for calculated elasticity (Ue), firmness of skin (R0), and overall elasticity (R8). After 3 months, no statistically significant differences in skin elasticity were detected between the different wound dressings.

CONCLUSIONS

The presented results give an opportunity to compare the wound dressings used for treatment with respect to skin elasticity and reveal the potential of the bovine collagen matrix in the treatment of superficial skin defects; therefore the results facilitate further evaluation of collagen matrix in surgical applications and regenerative medicine.

Authors+Show Affiliations

BG-Trauma Center, Eberhard Karls University, Department of Plastic and Hand Surgery, Reconstructive and Aesthetic Surgery, Tuebingen, Germany.BG-Trauma Center, Eberhard Karls University, Department of Plastic and Hand Surgery, Reconstructive and Aesthetic Surgery, Tuebingen, Germany.BG-Trauma Center, Eberhard Karls University, Department of Plastic and Hand Surgery, Reconstructive and Aesthetic Surgery, Tuebingen, Germany.HELIOS Klinikum Wuppertal GmbH, University Hospital Witten/Herdecke, Germany, Department of Plastic and Hand Surgery, Reconstructive and Aesthetic Surgery, Wuppertal, Germany.BG-Trauma Center, Eberhard Karls University, Department of Plastic and Hand Surgery, Reconstructive and Aesthetic Surgery, Tuebingen, Germany.BG-Trauma Center, Eberhard Karls University, Department of Plastic and Hand Surgery, Reconstructive and Aesthetic Surgery, Tuebingen, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27701129

Citation

Held, Manuel, et al. "Biomechanical Skin Property Evaluation for Wounds Treated With Synthetic and Biosynthetic Wound Dressings and a Newly Developed Collagen Matrix During Healing of Superficial Skin Defects in a Rat Models." Wounds : a Compendium of Clinical Research and Practice, vol. 28, no. 9, 2016, pp. 334-340.
Held M, Engelke AS, Tolzmann DS, et al. Biomechanical Skin Property Evaluation for Wounds Treated With Synthetic and Biosynthetic Wound Dressings and a Newly Developed Collagen Matrix During Healing of Superficial Skin Defects in a Rat Models. Wounds. 2016;28(9):334-340.
Held, M., Engelke, A. S., Tolzmann, D. S., Rahmanian-Schwarz, A., Schaller, H. E., & Rothenberger, J. (2016). Biomechanical Skin Property Evaluation for Wounds Treated With Synthetic and Biosynthetic Wound Dressings and a Newly Developed Collagen Matrix During Healing of Superficial Skin Defects in a Rat Models. Wounds : a Compendium of Clinical Research and Practice, 28(9), pp. 334-340.
Held M, et al. Biomechanical Skin Property Evaluation for Wounds Treated With Synthetic and Biosynthetic Wound Dressings and a Newly Developed Collagen Matrix During Healing of Superficial Skin Defects in a Rat Models. Wounds. 2016;28(9):334-340. PubMed PMID: 27701129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomechanical Skin Property Evaluation for Wounds Treated With Synthetic and Biosynthetic Wound Dressings and a Newly Developed Collagen Matrix During Healing of Superficial Skin Defects in a Rat Models. AU - Held,Manuel, AU - Engelke,Anne-Sophie, AU - Tolzmann,Dascha Sophie, AU - Rahmanian-Schwarz,Afshin, AU - Schaller,Hans-Eberhard, AU - Rothenberger,Jens, PY - 2016/10/5/entrez PY - 2016/10/5/pubmed PY - 2017/7/1/medline SP - 334 EP - 340 JF - Wounds : a compendium of clinical research and practice JO - Wounds VL - 28 IS - 9 N2 - INTRODUCTION: There is a high prevalence of superficial wounds such as partial-thickness burns. Treatment of these wounds frequently includes temporary application of wound dressings. The aim of this study was to compare a newly developed collagen matrix with commonly used temporary skin dressings for treatment of partial-thickness skin defects. MATERIALS AND METHODS: Through a skin dermatome, 42 standardized superficial skin defects were generated on the back of 28 adult male Lewis rats. The wounds were treated with a synthetic wound dressing (Suprathel, Polymedics Innovations Inc, Woodstock, GA) (n = 14), a biosynthetic skin dressing (Biobrane, Smith & Nephew, Hull, UK) (n = 14), or a newly developed bovine collagen matrix, Collagen Cell Carrier (Viscofan BioEngineering, Weinheim, Germany) (n = 14). Biomechanical properties of the skin were determined and compared every 10 days over a 3-month period of using the Cutometer MPA 580 (Courage + Khazaka Electronic GmbH, Cologne, Germany). RESULTS: As opposed to healthy skin, statistically significant differences were detected between days 10 and 30, and between days 60 and 80, for calculated elasticity (Ue), firmness of skin (R0), and overall elasticity (R8). After 3 months, no statistically significant differences in skin elasticity were detected between the different wound dressings. CONCLUSIONS: The presented results give an opportunity to compare the wound dressings used for treatment with respect to skin elasticity and reveal the potential of the bovine collagen matrix in the treatment of superficial skin defects; therefore the results facilitate further evaluation of collagen matrix in surgical applications and regenerative medicine. SN - 1943-2704 UR - https://www.unboundmedicine.com/medline/citation/27701129/Biomechanical_Skin_Property_Evaluation_for_Wounds_Treated_With_Synthetic_and_Biosynthetic_Wound_Dressings_and_a_Newly_Developed_Collagen_Matrix_During_Healing_of_Superficial_Skin_Defects_in_a_Rat_Models_ L2 - http://www.woundsresearch.com/article/biomechanical-skin-property-evaluation-wounds-treated-synthetic-and-biosynthetic-wound DB - PRIME DP - Unbound Medicine ER -