Tags

Type your tag names separated by a space and hit enter

Older men with severe disc degeneration have more incident vertebral fractures-the prospective MINOS cohort study.
Rheumatology (Oxford). 2017 01; 56(1):37-45.R

Abstract

OBJECTIVE

Data on the relationship between disc degeneration (DD) and fragility fractures in men are limited. The aim of this study was to prospectively analyse the risk of vertebral and non-vertebral fractures in men with thoracolumbar DD according to the severity of its radiological signs: disc space narrowing (DSN), osteophytes and endplate sclerosis.

METHODS

Men >50 years of age (n = 765) had lateral spine radiographs and DXA and were monitored prospectively. We analysed the risk of incident vertebral (7.5 years) and non-vertebral fractures (10 years) in men according to the severity of DD.

RESULTS

After adjustment for age and weight, BMD increased with increasing total DSN score, endplate sclerosis and osteophytosis. Over 7.5 years, 28 incident vertebral fractures occurred in 27 men. After adjustment for age, BMI, spine BMD, prior fractures and abdominal aortic calcifications, the vertebral fracture risk was 3-fold higher in the upper DSN quartile vs men without DSN. After adjustment for the same confounders, vertebral fracture risk was also nearly 3-fold higher in the upper DSN quartile vs the three lower quartiles combined. Over 10 years, 61 men sustained non-vertebral fragility fractures. After adjustment for age, BMI, hip BMD, abdominal aortic calcifications and prior falls and fractures, the non-vertebral fracture risk decreased with increasing DSN score. The risk of non-vertebral fracture was half as high in men above the median total DSN score vs men below the median.

CONCLUSION

In older men, severe DD is associated with higher BMD. Multilevel severe DSN is associated with higher vertebral fracture risk and lower non-vertebral fracture risk.

Authors+Show Affiliations

Department of Rheumatology, Hôpital Edouard Herriot, INSERM UMR 1033, University of Lyon, Lyon, France.Department of Rheumatology, Hôpital Edouard Herriot, INSERM UMR 1033, University of Lyon, Lyon, France.Department of Rheumatology, Hôpital Edouard Herriot, INSERM UMR 1033, University of Lyon, Lyon, France pawel.szulc@inserm.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27703044

Citation

Estublier, Charline, et al. "Older Men With Severe Disc Degeneration Have More Incident Vertebral Fractures-the Prospective MINOS Cohort Study." Rheumatology (Oxford, England), vol. 56, no. 1, 2017, pp. 37-45.
Estublier C, Chapurlat R, Szulc P. Older men with severe disc degeneration have more incident vertebral fractures-the prospective MINOS cohort study. Rheumatology (Oxford). 2017;56(1):37-45.
Estublier, C., Chapurlat, R., & Szulc, P. (2017). Older men with severe disc degeneration have more incident vertebral fractures-the prospective MINOS cohort study. Rheumatology (Oxford, England), 56(1), 37-45. https://doi.org/10.1093/rheumatology/kew327
Estublier C, Chapurlat R, Szulc P. Older Men With Severe Disc Degeneration Have More Incident Vertebral Fractures-the Prospective MINOS Cohort Study. Rheumatology (Oxford). 2017;56(1):37-45. PubMed PMID: 27703044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Older men with severe disc degeneration have more incident vertebral fractures-the prospective MINOS cohort study. AU - Estublier,Charline, AU - Chapurlat,Roland, AU - Szulc,Pawel, Y1 - 2016/10/03/ PY - 2016/04/09/received PY - 2016/07/29/revised PY - 2016/10/6/pubmed PY - 2019/3/21/medline PY - 2016/10/6/entrez KW - bone mineral density KW - disc degeneration KW - fracture KW - men KW - prospective cohort study SP - 37 EP - 45 JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) VL - 56 IS - 1 N2 - OBJECTIVE: Data on the relationship between disc degeneration (DD) and fragility fractures in men are limited. The aim of this study was to prospectively analyse the risk of vertebral and non-vertebral fractures in men with thoracolumbar DD according to the severity of its radiological signs: disc space narrowing (DSN), osteophytes and endplate sclerosis. METHODS: Men >50 years of age (n = 765) had lateral spine radiographs and DXA and were monitored prospectively. We analysed the risk of incident vertebral (7.5 years) and non-vertebral fractures (10 years) in men according to the severity of DD. RESULTS: After adjustment for age and weight, BMD increased with increasing total DSN score, endplate sclerosis and osteophytosis. Over 7.5 years, 28 incident vertebral fractures occurred in 27 men. After adjustment for age, BMI, spine BMD, prior fractures and abdominal aortic calcifications, the vertebral fracture risk was 3-fold higher in the upper DSN quartile vs men without DSN. After adjustment for the same confounders, vertebral fracture risk was also nearly 3-fold higher in the upper DSN quartile vs the three lower quartiles combined. Over 10 years, 61 men sustained non-vertebral fragility fractures. After adjustment for age, BMI, hip BMD, abdominal aortic calcifications and prior falls and fractures, the non-vertebral fracture risk decreased with increasing DSN score. The risk of non-vertebral fracture was half as high in men above the median total DSN score vs men below the median. CONCLUSION: In older men, severe DD is associated with higher BMD. Multilevel severe DSN is associated with higher vertebral fracture risk and lower non-vertebral fracture risk. SN - 1462-0332 UR - https://www.unboundmedicine.com/medline/citation/27703044/Older_men_with_severe_disc_degeneration_have_more_incident_vertebral_fractures_the_prospective_MINOS_cohort_study_ L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/kew327 DB - PRIME DP - Unbound Medicine ER -