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Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial.
Drug Des Devel Ther. 2016; 10:3005-3012.DD

Abstract

INTRODUCTION

Shivering is among the unpleasant and potentially harmful side effects of spinal anesthesia. The aim of this randomized double-blind clinical trial was to compare the antishivering effect of two different doses of intrathecal pethidine on the incidence and intensity of shivering and other side effects in patients who underwent cesarean section.

METHODS

In this study, 150 parturient females scheduled for nonemergent cesarean section were randomly allocated to three groups. Spinal anesthesia was performed with 0.5% hyperbaric bupivacaine (12.5 mg), plus 0.5 mL of 0.9% saline in the standard group (S group), and the same dose of bupivacaine with 5 mg (P5 group) or 10 mg of pethidine (P10 group). Demographic and surgical data, incidence and intensity of shivering (primary outcome), hemodynamic indices, forehead and core temperatures, maximum sensory level, Apgar scores, and adverse events were evaluated by a blinded observer.

RESULTS

There were no significant differences between the three study groups regarding the demographic and surgical data, hemodynamic indices, core temperatures, and maximum sensory level (P>0.05). The incidence and intensity of shivering were significantly less in the P5 and P10 groups (P<0.001) when compared with the S group. There were no significant differences between groups for secondary outcomes, except pruritus, which was more common in the P5 and P10 groups when compared with the S group (P=0.01).

CONCLUSION

Low dose of intrathecal pethidine is safe, and can decrease the incidence and intensity of shivering during cesarean section, without having major side effects.

Authors+Show Affiliations

Department of Surgical Nursing, School of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Anesthesia and Intensive Care, Social Determinants of Health Research Center, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Anesthesia and Intensive Care, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Anesthesia and Intensive Care, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Anesthesia and Intensive Care, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.Student Research Committee, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Surgical Nursing, School of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

27703328

Citation

Shami, Shoaleh, et al. "Effect of Low Dose of Intrathecal Pethidine On the Incidence and Intensity of Shivering During Cesarean Section Under Spinal Anesthesia: a Randomized, Placebo-controlled, Double-blind Clinical Trial." Drug Design, Development and Therapy, vol. 10, 2016, pp. 3005-3012.
Shami S, Nasseri K, Shirmohammadi M, et al. Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial. Drug Des Devel Ther. 2016;10:3005-3012.
Shami, S., Nasseri, K., Shirmohammadi, M., Sarshivi, F., Ghadami, N., Ghaderi, E., Pouladi, M., & Barzanji, A. (2016). Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial. Drug Design, Development and Therapy, 10, 3005-3012.
Shami S, et al. Effect of Low Dose of Intrathecal Pethidine On the Incidence and Intensity of Shivering During Cesarean Section Under Spinal Anesthesia: a Randomized, Placebo-controlled, Double-blind Clinical Trial. Drug Des Devel Ther. 2016;10:3005-3012. PubMed PMID: 27703328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial. AU - Shami,Shoaleh, AU - Nasseri,Karim, AU - Shirmohammadi,Mousa, AU - Sarshivi,Farzad, AU - Ghadami,Negin, AU - Ghaderi,Ebrahim, AU - Pouladi,Mokhtar, AU - Barzanji,Arvin, Y1 - 2016/09/20/ PY - 2016/10/6/entrez PY - 2016/10/6/pubmed PY - 2017/4/27/medline KW - cesarean section KW - intrathecal pethidine KW - nausea KW - prevention KW - shivering KW - vomiting SP - 3005 EP - 3012 JF - Drug design, development and therapy JO - Drug Des Devel Ther VL - 10 N2 - INTRODUCTION: Shivering is among the unpleasant and potentially harmful side effects of spinal anesthesia. The aim of this randomized double-blind clinical trial was to compare the antishivering effect of two different doses of intrathecal pethidine on the incidence and intensity of shivering and other side effects in patients who underwent cesarean section. METHODS: In this study, 150 parturient females scheduled for nonemergent cesarean section were randomly allocated to three groups. Spinal anesthesia was performed with 0.5% hyperbaric bupivacaine (12.5 mg), plus 0.5 mL of 0.9% saline in the standard group (S group), and the same dose of bupivacaine with 5 mg (P5 group) or 10 mg of pethidine (P10 group). Demographic and surgical data, incidence and intensity of shivering (primary outcome), hemodynamic indices, forehead and core temperatures, maximum sensory level, Apgar scores, and adverse events were evaluated by a blinded observer. RESULTS: There were no significant differences between the three study groups regarding the demographic and surgical data, hemodynamic indices, core temperatures, and maximum sensory level (P>0.05). The incidence and intensity of shivering were significantly less in the P5 and P10 groups (P<0.001) when compared with the S group. There were no significant differences between groups for secondary outcomes, except pruritus, which was more common in the P5 and P10 groups when compared with the S group (P=0.01). CONCLUSION: Low dose of intrathecal pethidine is safe, and can decrease the incidence and intensity of shivering during cesarean section, without having major side effects. SN - 1177-8881 UR - https://www.unboundmedicine.com/medline/citation/27703328/Effect_of_low_dose_of_intrathecal_pethidine_on_the_incidence_and_intensity_of_shivering_during_cesarean_section_under_spinal_anesthesia:_a_randomized_placebo_controlled_double_blind_clinical_trial_ L2 - https://dx.doi.org/10.2147/DDDT.S115201 DB - PRIME DP - Unbound Medicine ER -