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Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries.
Nutrients 2016; 8(10)N

Abstract

Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic characteristics, and dietary habits (assessed by a short food frequency questionnaire) in a cross-sectional study of 2118 women and men (age-stratified from 35 to 74 years) of the general population from six European countries. Higher age was associated with lower lycopene and α-/β-carotene and higher β-cryptoxanthin, lutein, zeaxanthin, α-/γ-tocopherol, and retinol levels. Significant correlations with age were observed for lycopene (r = -0.248), α-tocopherol (r = 0.208), α-carotene (r = -0.112), and β-cryptoxanthin (r = 0.125; all p < 0.001). Age was inversely associated with lycopene (-6.5% per five-year age increase) and this association remained in the multiple regression model with the significant predictors (covariables) being country, season, cholesterol, gender, smoking status, body mass index (BMI (kg/m²)), and dietary habits. The positive association of α-tocopherol with age remained when all covariates including cholesterol and use of vitamin supplements were included (1.7% vs. 2.4% per five-year age increase). The association of higher β-cryptoxanthin with higher age was no longer statistically significant after adjustment for fruit consumption, whereas the inverse association of α-carotene with age remained in the fully adjusted multivariable model (-4.8% vs. -3.8% per five-year age increase). We conclude from our study that age is an independent predictor of plasma lycopene, α-tocopherol, and α-carotene.

Authors+Show Affiliations

Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart 70599, Germany. Wolfgang.Stuetz@uni-hohenheim.de. Institute of Nutrition, Friedrich-Schiller-University, Jena 07743, Germany. Wolfgang.Stuetz@uni-hohenheim.de.Institute of Nutrition, Friedrich-Schiller-University, Jena 07743, Germany. Daniela.Weber@dife.de. Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal 14558, Germany. Daniela.Weber@dife.de.National Institute of Public Health and the Environment (RIVM), BA Bilthoven 3721, The Netherlands. Martijn.Dolle@rivm.nl.National Institute of Public Health and the Environment (RIVM), BA Bilthoven 3721, The Netherlands. eugene.jansen@rivm.nl.Institute for Biomedical Aging Research, Leipold-Franzens-University, Innsbruck 6020, Austria. beatrix.grubeck@uibk.ac.at.Institute for Nutritional Sciences and Physiology, University for Health Sciences, Hall in Tirol 6060, Austria. simone.fiegl@umit.at.Unit of Cellular Biochemistry and Biology, University of Namur, Namur 5000, Belgium. olivier.toussaint@fundp.ac.be.BioTeSys GmbH, Esslingen 73728, Germany. j.bernhardt@biotesys.de.Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Athens 11635, Greece. sgonos@eie.gr.Department of Experimental Pathology, University of Bologna, Bologna 40126, Italy. claudio.franceschi@unibo.it.Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw 02-093, Poland. e.sikora@nencki.gov.pl.Molecular Toxicology, Department of Biology, University of Konstanz, Konstanz 78457, Germany. maria.moreno-villanueva@uni-konstanz.de.Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart 70599, Germany. breusing@uni-hohenheim.de. Department of Applied Nutritional Science/Dietetics, Institute of Nutritional Medicine, University of Hohenheim, Stuttgart 70599, Germany. breusing@uni-hohenheim.de.Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal 14558, Germany. scientific.director@dife.de. German Center for Diabetes Research (DZD), Munich-Neuherberg 85764, Germany. scientific.director@dife.de. German Center for Cardiovascular Research (DZHK), Berlin 13357, Germany. scientific.director@dife.de. NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal 14458, Germany. scientific.director@dife.de.Molecular Toxicology, Department of Biology, University of Konstanz, Konstanz 78457, Germany. alexander.buerkle@uni-konstanz.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27706032

Citation

Stuetz, Wolfgang, et al. "Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: a Cross-Sectional Study in Six European Countries." Nutrients, vol. 8, no. 10, 2016.
Stuetz W, Weber D, Dollé ME, et al. Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries. Nutrients. 2016;8(10).
Stuetz, W., Weber, D., Dollé, M. E., Jansen, E., Grubeck-Loebenstein, B., Fiegl, S., ... Bürkle, A. (2016). Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries. Nutrients, 8(10).
Stuetz W, et al. Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: a Cross-Sectional Study in Six European Countries. Nutrients. 2016 Sep 30;8(10) PubMed PMID: 27706032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries. AU - Stuetz,Wolfgang, AU - Weber,Daniela, AU - Dollé,Martijn E T, AU - Jansen,Eugène, AU - Grubeck-Loebenstein,Beatrix, AU - Fiegl,Simone, AU - Toussaint,Olivier, AU - Bernhardt,Juergen, AU - Gonos,Efstathios S, AU - Franceschi,Claudio, AU - Sikora,Ewa, AU - Moreno-Villanueva,María, AU - Breusing,Nicolle, AU - Grune,Tilman, AU - Bürkle,Alexander, Y1 - 2016/09/30/ PY - 2016/07/19/received PY - 2016/09/26/revised PY - 2016/09/27/accepted PY - 2016/10/6/entrez PY - 2016/10/6/pubmed PY - 2017/5/26/medline KW - Europe KW - age KW - carotenoids KW - lycopene KW - micronutrients KW - plasma KW - retinol KW - tocopherols JF - Nutrients JO - Nutrients VL - 8 IS - 10 N2 - Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic characteristics, and dietary habits (assessed by a short food frequency questionnaire) in a cross-sectional study of 2118 women and men (age-stratified from 35 to 74 years) of the general population from six European countries. Higher age was associated with lower lycopene and α-/β-carotene and higher β-cryptoxanthin, lutein, zeaxanthin, α-/γ-tocopherol, and retinol levels. Significant correlations with age were observed for lycopene (r = -0.248), α-tocopherol (r = 0.208), α-carotene (r = -0.112), and β-cryptoxanthin (r = 0.125; all p < 0.001). Age was inversely associated with lycopene (-6.5% per five-year age increase) and this association remained in the multiple regression model with the significant predictors (covariables) being country, season, cholesterol, gender, smoking status, body mass index (BMI (kg/m²)), and dietary habits. The positive association of α-tocopherol with age remained when all covariates including cholesterol and use of vitamin supplements were included (1.7% vs. 2.4% per five-year age increase). The association of higher β-cryptoxanthin with higher age was no longer statistically significant after adjustment for fruit consumption, whereas the inverse association of α-carotene with age remained in the fully adjusted multivariable model (-4.8% vs. -3.8% per five-year age increase). We conclude from our study that age is an independent predictor of plasma lycopene, α-tocopherol, and α-carotene. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/27706032/Plasma_Carotenoids_Tocopherols_and_Retinol_in_the_Age_Stratified__35_74_Years__General_Population:_A_Cross_Sectional_Study_in_Six_European_Countries_ L2 - http://www.mdpi.com/resolver?pii=nu8100614 DB - PRIME DP - Unbound Medicine ER -