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Yellow fever vaccine-associated neurotropic disease (YEL-AND) - A case report.
Neurol Neurochir Pol. 2017 Jan - Feb; 51(1):101-105.NN

Abstract

Yellow fever (YF) is a mosquito-borne viral hemorrhagic fever, which is a serious and potentially fatal disease with no specific antiviral treatment that can be effectively prevented by an attenuated vaccine (YEL). Despite the long history of safe and efficacious YF vaccination, sporadic case reports of serious adverse events (SAEs) have been reported, including yellow fever vaccine-associated neurotropic disease (YEL-AND). YEL-AND usually appears within one month of YF vaccination, manifesting as meningoencephalitis, Guillain-Barré syndrome (GBS) or acute disseminated encephalomyelitis (ADEM). We report a case of YEL-AND with meningitis presentation in a 39-year-old Caucasian man without evidence of significant risk factors, which was confirmed by the presence of the YF virus and specific immunoglobulin G (IgG) antibodies in the cerebrospinal fluid (CSF). In conclusion, we should stress the importance of balancing the risk of SAEs associated with the vaccine and the benefits of YF vaccination for each patient individually.

Authors+Show Affiliations

Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: jolaflorczak@op.pl.Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland.Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

27707454

Citation

Florczak-Wyspiańska, Jolanta, et al. "Yellow Fever Vaccine-associated Neurotropic Disease (YEL-AND) - a Case Report." Neurologia I Neurochirurgia Polska, vol. 51, no. 1, 2017, pp. 101-105.
Florczak-Wyspiańska J, Nawotczyńska E, Kozubski W. Yellow fever vaccine-associated neurotropic disease (YEL-AND) - A case report. Neurol Neurochir Pol. 2017;51(1):101-105.
Florczak-Wyspiańska, J., Nawotczyńska, E., & Kozubski, W. (2017). Yellow fever vaccine-associated neurotropic disease (YEL-AND) - A case report. Neurologia I Neurochirurgia Polska, 51(1), 101-105. https://doi.org/10.1016/j.pjnns.2016.09.002
Florczak-Wyspiańska J, Nawotczyńska E, Kozubski W. Yellow Fever Vaccine-associated Neurotropic Disease (YEL-AND) - a Case Report. Neurol Neurochir Pol. 2017 Jan - Feb;51(1):101-105. PubMed PMID: 27707454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Yellow fever vaccine-associated neurotropic disease (YEL-AND) - A case report. AU - Florczak-Wyspiańska,Jolanta, AU - Nawotczyńska,Ewa, AU - Kozubski,Wojciech, Y1 - 2016/09/22/ PY - 2016/03/06/received PY - 2016/09/10/revised PY - 2016/09/14/accepted PY - 2016/10/7/pubmed PY - 2017/6/21/medline PY - 2016/10/7/entrez KW - Adverse event KW - Neurological disease KW - Yellow fever vaccine SP - 101 EP - 105 JF - Neurologia i neurochirurgia polska JO - Neurol Neurochir Pol VL - 51 IS - 1 N2 - Yellow fever (YF) is a mosquito-borne viral hemorrhagic fever, which is a serious and potentially fatal disease with no specific antiviral treatment that can be effectively prevented by an attenuated vaccine (YEL). Despite the long history of safe and efficacious YF vaccination, sporadic case reports of serious adverse events (SAEs) have been reported, including yellow fever vaccine-associated neurotropic disease (YEL-AND). YEL-AND usually appears within one month of YF vaccination, manifesting as meningoencephalitis, Guillain-Barré syndrome (GBS) or acute disseminated encephalomyelitis (ADEM). We report a case of YEL-AND with meningitis presentation in a 39-year-old Caucasian man without evidence of significant risk factors, which was confirmed by the presence of the YF virus and specific immunoglobulin G (IgG) antibodies in the cerebrospinal fluid (CSF). In conclusion, we should stress the importance of balancing the risk of SAEs associated with the vaccine and the benefits of YF vaccination for each patient individually. SN - 0028-3843 UR - https://www.unboundmedicine.com/medline/citation/27707454/Yellow_fever_vaccine_associated_neurotropic_disease__YEL_AND____A_case_report_ L2 - http://www.diseaseinfosearch.org/result/7583 DB - PRIME DP - Unbound Medicine ER -