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B-vitamins potentiate the antinociceptive effect of diclofenac in carrageenin-induced hyperalgesia in the rat tail pressure test.
Neurosci Lett. 1989 Jun 05; 101(1):95-100.NL

Abstract

B-vitamins possess antinociceptive and antiinflammatory activity. The rat tail pressure test was used to examine whether a mixture of the vitamins B1, B6, and B12, clinically used as Neurobion, has antinociceptive activity itself or potentiates the effect of the non-steroidal antiinflammatory drug (NSAID) diclofenac on carrageenin-induced hyperalgesia. Only the highest dose of the vitamin mixture (667 mg/kg B1 and B6, 6.7 mg/kg B12 p.o.) exhibited antinociceptive activity. Nevertheless, lower doses which alone were lacking in activity (100-250 mg/kg B1 and B6, 1-2.5 mg/kg B12 p.o.) dose-dependently potentiated the antinociceptive of diclofenac. This result supports the clinical experience of a reduced need for diclofenac when B-vitamins are administered concomitantly.

Authors+Show Affiliations

E. Merck, Department of Pharmacology, Darmstadt, F.R.G.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2771158

Citation

Bartoszyk, G D., and A Wild. "B-vitamins Potentiate the Antinociceptive Effect of Diclofenac in Carrageenin-induced Hyperalgesia in the Rat Tail Pressure Test." Neuroscience Letters, vol. 101, no. 1, 1989, pp. 95-100.
Bartoszyk GD, Wild A. B-vitamins potentiate the antinociceptive effect of diclofenac in carrageenin-induced hyperalgesia in the rat tail pressure test. Neurosci Lett. 1989;101(1):95-100.
Bartoszyk, G. D., & Wild, A. (1989). B-vitamins potentiate the antinociceptive effect of diclofenac in carrageenin-induced hyperalgesia in the rat tail pressure test. Neuroscience Letters, 101(1), 95-100.
Bartoszyk GD, Wild A. B-vitamins Potentiate the Antinociceptive Effect of Diclofenac in Carrageenin-induced Hyperalgesia in the Rat Tail Pressure Test. Neurosci Lett. 1989 Jun 5;101(1):95-100. PubMed PMID: 2771158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - B-vitamins potentiate the antinociceptive effect of diclofenac in carrageenin-induced hyperalgesia in the rat tail pressure test. AU - Bartoszyk,G D, AU - Wild,A, PY - 1989/6/5/pubmed PY - 1989/6/5/medline PY - 1989/6/5/entrez SP - 95 EP - 100 JF - Neuroscience letters JO - Neurosci Lett VL - 101 IS - 1 N2 - B-vitamins possess antinociceptive and antiinflammatory activity. The rat tail pressure test was used to examine whether a mixture of the vitamins B1, B6, and B12, clinically used as Neurobion, has antinociceptive activity itself or potentiates the effect of the non-steroidal antiinflammatory drug (NSAID) diclofenac on carrageenin-induced hyperalgesia. Only the highest dose of the vitamin mixture (667 mg/kg B1 and B6, 6.7 mg/kg B12 p.o.) exhibited antinociceptive activity. Nevertheless, lower doses which alone were lacking in activity (100-250 mg/kg B1 and B6, 1-2.5 mg/kg B12 p.o.) dose-dependently potentiated the antinociceptive of diclofenac. This result supports the clinical experience of a reduced need for diclofenac when B-vitamins are administered concomitantly. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/2771158/B_vitamins_potentiate_the_antinociceptive_effect_of_diclofenac_in_carrageenin_induced_hyperalgesia_in_the_rat_tail_pressure_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0304-3940(89)90447-3 DB - PRIME DP - Unbound Medicine ER -