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Zika virus epidemic: an update.
Expert Rev Anti Infect Ther. 2016 12; 14(12):1127-1138.ER

Abstract

INTRODUCTION

Zika Virus (ZIKV), previously the cause of only rare and sporadic human infections, is now considered a Public Health Emergency of International Concern. Over the past two years, ZIKV has become a pandemic encompassing much of the Americas. ZIKV is now proven to cause microcephaly and ophthalmic anomalies in the newborn. Hydrops fetalis, developmental delay, and other anomalies are increasingly being attributed to ZIKV infection in fetuses and neonates. Sequelae of congenital infection and rapid spread of ZIKV throughout the Americas has catapulted Zika virus concerns to the forefront of the medical community. Areas covered: This review seeks to consolidate ZIKV epidemiology, diagnostic testing methods, CDC screening recommendations, and preventive strategies including potential vaccines. Expert commentary: Many unknowns still exist regarding ZIKV infections and its long-term effects in neonates. In addition, further studies need to evaluate if genomic differences that have occurred from the African to the Asian lineage of the virus have led to increased virulence of the virus. The authors believe that all pregnant women with fetuses showing microcephaly and/or intracranial calcifications should be tested for ZIKV infection if they cannot recall their sexual partner travel history. This change from the current CDCs recommendations could increase substantially the number of pregnant women and neonates, screened for ZIKV.

Authors+Show Affiliations

a Department of Pediatrics , One Baylor Plaza , Houston , TX , USA.b Department of Pediatrics, Section of Infectious Diseases , Baylor College of Medicine , Houston , TX , USA.c Department of Pediatrics, Section of Neonatology , Baylor College of Medicine , Houston , TX , USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27712118

Citation

Valentine, Gregory, et al. "Zika Virus Epidemic: an Update." Expert Review of Anti-infective Therapy, vol. 14, no. 12, 2016, pp. 1127-1138.
Valentine G, Marquez L, Pammi M. Zika virus epidemic: an update. Expert Rev Anti Infect Ther. 2016;14(12):1127-1138.
Valentine, G., Marquez, L., & Pammi, M. (2016). Zika virus epidemic: an update. Expert Review of Anti-infective Therapy, 14(12), 1127-1138.
Valentine G, Marquez L, Pammi M. Zika Virus Epidemic: an Update. Expert Rev Anti Infect Ther. 2016;14(12):1127-1138. PubMed PMID: 27712118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zika virus epidemic: an update. AU - Valentine,Gregory, AU - Marquez,Lucila, AU - Pammi,Mohan, Y1 - 2016/10/21/ PY - 2016/10/8/pubmed PY - 2017/10/31/medline PY - 2016/10/8/entrez KW - Zika virus KW - arbovirus KW - congenital infection KW - global health KW - vaccine SP - 1127 EP - 1138 JF - Expert review of anti-infective therapy JO - Expert Rev Anti Infect Ther VL - 14 IS - 12 N2 - INTRODUCTION: Zika Virus (ZIKV), previously the cause of only rare and sporadic human infections, is now considered a Public Health Emergency of International Concern. Over the past two years, ZIKV has become a pandemic encompassing much of the Americas. ZIKV is now proven to cause microcephaly and ophthalmic anomalies in the newborn. Hydrops fetalis, developmental delay, and other anomalies are increasingly being attributed to ZIKV infection in fetuses and neonates. Sequelae of congenital infection and rapid spread of ZIKV throughout the Americas has catapulted Zika virus concerns to the forefront of the medical community. Areas covered: This review seeks to consolidate ZIKV epidemiology, diagnostic testing methods, CDC screening recommendations, and preventive strategies including potential vaccines. Expert commentary: Many unknowns still exist regarding ZIKV infections and its long-term effects in neonates. In addition, further studies need to evaluate if genomic differences that have occurred from the African to the Asian lineage of the virus have led to increased virulence of the virus. The authors believe that all pregnant women with fetuses showing microcephaly and/or intracranial calcifications should be tested for ZIKV infection if they cannot recall their sexual partner travel history. This change from the current CDCs recommendations could increase substantially the number of pregnant women and neonates, screened for ZIKV. SN - 1744-8336 UR - https://www.unboundmedicine.com/medline/citation/27712118/Zika_virus_epidemic:_an_update_ L2 - http://www.tandfonline.com/doi/full/10.1080/14787210.2016.1245614 DB - PRIME DP - Unbound Medicine ER -