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Formulation Development and Optimization of Matrix Tablet of Tramadol Hydrochloride.
Recent Pat Drug Deliv Formul. 2017; 11(1):19-27.RP

Abstract

BACKGROUND

The aim of the present investigation is to formulate and optimize oral sustained release matrix tablet of highly water soluble drug Tramadol HCl and to evaluate the effect of varying concentration of hydrophilic and hydrophobic polymer on drug release, based on a survey done on the recent patents of Tramadol HCl (US7374781, CA 2479252) and sustained release matrix tablets.

METHODS

The tablets were prepared by double granulation process, by melt granulation and wet granulation technique using Carnauba wax (CW) and HPMC K100 as release retardant.

RESULTS

Pre and post compression factors were evaluated and all the parameters were found within the limit. The drug release data were subjected to different models in order to evaluate release kinetics and mechanism of drug release. The prepared formulations showed drug release in the range 100±2% in 6hrs, 7hrs, 8hrs and 9hrs and upto 12 hrs respectively. The optimized tablet having 25% CW and 20% HPMC showed sustained drug release pattern. Hydrophilic matrix of HPMC alone could not control the Tramadol release effectively for 12 h whereas when combined with CW could slow down the release of drug and can be successfully employed for formulating sustained-release matrix tablets. Similarity factor, f2 shows the test and reference profile are identical.

CONCLUSION

Double granulation technique with CW and HPMC K100 proved as a better technique for sustaining the drug release from the matrix tablet.

Authors+Show Affiliations

Institute of Pharmacy, Gauhati Medical College - Dept. of Pharmaceutics, Guwahati, Assam, India.Girijananda Chowdhury Institute of Pharmaceutical Sciences, Guwahati-781017 - Pharmaceutics Guwahati, Assam, India.Girijananda Chowdhury Institute of Pharmaceutical Sciences, Guwahati-781017, India - Pharmaceutics, Guwahati, Assam, India.Bengal College of Pharmaceutical Sciences and Research Pharmaceutics, West Bengal, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27712568

Citation

Deb, Pulak, et al. "Formulation Development and Optimization of Matrix Tablet of Tramadol Hydrochloride." Recent Patents On Drug Delivery & Formulation, vol. 11, no. 1, 2017, pp. 19-27.
Deb P, Singha J, Chanda I, et al. Formulation Development and Optimization of Matrix Tablet of Tramadol Hydrochloride. Recent Pat Drug Deliv Formul. 2017;11(1):19-27.
Deb, P., Singha, J., Chanda, I., & Chakraborty, P. (2017). Formulation Development and Optimization of Matrix Tablet of Tramadol Hydrochloride. Recent Patents On Drug Delivery & Formulation, 11(1), 19-27. https://doi.org/10.2174/1872211310666161004160304
Deb P, et al. Formulation Development and Optimization of Matrix Tablet of Tramadol Hydrochloride. Recent Pat Drug Deliv Formul. 2017;11(1):19-27. PubMed PMID: 27712568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation Development and Optimization of Matrix Tablet of Tramadol Hydrochloride. AU - Deb,Pulak, AU - Singha,Jubaraj, AU - Chanda,Indranil, AU - Chakraborty,Prithviraj, PY - 2016/5/6/received PY - 2016/8/4/revised PY - 2016/10/4/accepted PY - 2016/10/8/pubmed PY - 2018/1/9/medline PY - 2016/10/8/entrez KW - CW KW - DSC KW - FT-IR KW - HPMC KW - Tramadol HCl KW - matrix tablet SP - 19 EP - 27 JF - Recent patents on drug delivery & formulation JO - Recent Pat Drug Deliv Formul VL - 11 IS - 1 N2 - BACKGROUND: The aim of the present investigation is to formulate and optimize oral sustained release matrix tablet of highly water soluble drug Tramadol HCl and to evaluate the effect of varying concentration of hydrophilic and hydrophobic polymer on drug release, based on a survey done on the recent patents of Tramadol HCl (US7374781, CA 2479252) and sustained release matrix tablets. METHODS: The tablets were prepared by double granulation process, by melt granulation and wet granulation technique using Carnauba wax (CW) and HPMC K100 as release retardant. RESULTS: Pre and post compression factors were evaluated and all the parameters were found within the limit. The drug release data were subjected to different models in order to evaluate release kinetics and mechanism of drug release. The prepared formulations showed drug release in the range 100±2% in 6hrs, 7hrs, 8hrs and 9hrs and upto 12 hrs respectively. The optimized tablet having 25% CW and 20% HPMC showed sustained drug release pattern. Hydrophilic matrix of HPMC alone could not control the Tramadol release effectively for 12 h whereas when combined with CW could slow down the release of drug and can be successfully employed for formulating sustained-release matrix tablets. Similarity factor, f2 shows the test and reference profile are identical. CONCLUSION: Double granulation technique with CW and HPMC K100 proved as a better technique for sustaining the drug release from the matrix tablet. SN - 2212-4039 UR - https://www.unboundmedicine.com/medline/citation/27712568/Formulation_Development_and_Optimization_of_Matrix_Tablet_of_Tramadol_Hydrochloride_ DB - PRIME DP - Unbound Medicine ER -